Liposomes Conjugated with a Pilot Molecule

Shimizu, Kosuke; Oku, Naoto

doi:10.1007/978-4-431-56880-3_9

Cited by 2 publications

(3 citation statements)

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“…However, PEGylation is known to stabilize the liposomes by lowering their interaction with serum proteins and avoiding removal by the reticuloendothelial system. Longevity of liposomes in the bloodstream may result in poor uptake into the targeted cells [ 76 ]. Besides transferrin, other tumor targeting moieties such as folate, monoclonal antibodies and epidermal growth factors have also been used in conjunction with liposomes to improve their delivery efficiency [ 8 , 64 , 76 ].…”

Section: Boron-containing Liposomesmentioning

confidence: 99%

“…Longevity of liposomes in the bloodstream may result in poor uptake into the targeted cells [ 76 ]. Besides transferrin, other tumor targeting moieties such as folate, monoclonal antibodies and epidermal growth factors have also been used in conjunction with liposomes to improve their delivery efficiency [ 8 , 64 , 76 ]. Folate receptors and epidermal growth factor receptors (EGFR) are overexpressed in tumor cells compared to normal cells.…”

Section: Boron-containing Liposomesmentioning

confidence: 99%

“…Folate receptors and epidermal growth factor receptors (EGFR) are overexpressed in tumor cells compared to normal cells. This makes them suitable targets when folate or epidermal growth factor-conjugated liposomes are used for boron delivery [ 76 ]. For example, EGFR-targeted PEG liposomes exhibited a high (90 ppm) cellular uptake of 10 B.…”

Section: Boron-containing Liposomesmentioning

confidence: 99%

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Multi-Functional Boron-Delivery Agents for Boron Neutron Capture Therapy of Cancers

Oloo,

Smith,

Vicente

2023

Cancers

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Boron neutron capture therapy (BNCT) is a binary cancer treatment that involves the irradiation of 10B-containing tumors with low-energy neutrons (thermal or epithermal). The alpha particles and recoiling Li nuclei that are produced in the 10B-capture nuclear reaction are high-linear-energy transfer particles that destroy boron-loaded tumor cells; therefore, BNCT has the potential to be a localized therapeutic modality. Two boron-delivery agents have been used in clinical trials of BNCT in patients with malignant brain tumors, cutaneous melanoma, or recurrent tumors of the head and neck region, demonstrating the potential of BNCT in the treatment of difficult cancers. A variety of potentially highly effective boron-delivery agents have been synthesized in the past four decades and tested in cells and animal models. These include boron-containing nucleosides, peptides, proteins, polyamines, porphyrins, liposomes, monoclonal antibodies, and nanoparticles of various types. The most promising agents are multi-functional boronated molecules and nanoparticles functionalized with tumor cell-targeting moieties that increase their tumor selectivity and contain a radiolabel or fluorophore to allow quantification of 10B-biodistribution and treatment planning. This review discusses multi-functional boron agents reported in the last decade, but their full potential can only be ascertained after their evaluation in BNCT clinical trials.

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