Liposomes as potential biolubricant additives for wear reduction in human synovial joints

Verberne, Gabi; Schroeder, Avi; Halperin, G.; Barenholz, Yechezkel; Etsion, I.

doi:10.1016/j.wear.2009.12.037

Cited by 30 publications

(26 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Lamellar-repulsive Lubrication Mechanism Between Cartilage/csupporting

confidence: 86%

“…The joint's lubrication within the lamellar-repulsive mechanism is consistent with the literature data [3,42]. Some authors [3,42] have proposed that the lubrication is provided by phospholipids that form a multi-bilayer structure over the articular surface of cartilage; these phospholipids are known as surface active phospholipids. The lubrication mechanism in joints occurs both: (i) through lamellar lubrication, which occurs when the bilayers slide over each other, and (ii) through the structured synovial fluid when the lamellar spheres, liposomes, and macromolecules act like a roller-bearing between two cartilage surfaces to achieve effective biological lubrication [43].…”

Section: Lamellar-repulsive Lubrication Mechanism Between Cartilage/csupporting

confidence: 86%

See 1 more Smart Citation

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

View full text Add to dashboard Cite

Some solid lubricants are characterized by a layered structure with weak (van der Waals) inter-interlayer forces which allow for easy, low-strength shearing. Solid lubricants in natural lubrication are characterized by phospholipid bilayers in the articular joints and phospholipid lamellar phases in synovial fluid. The influence of the acid–base properties of the phospholipid bilayer on the wettability and properties of the surface have been explained by studying the interfacial tension of spherical lipid bilayers based on a model membrane. In this paper, we show that the phospholipid multi-bilayer can act as an effective solid lubricant in every aspect, ranging from a ‘corrosion inhibitor’ in the stomach to a load-bearing lubricant in bovine joints. We present evidence of the outstanding performance of phospholipids and argue that this is due to their chemical inertness and hydrophilic–hydrophobic structure, which makes them amphoteric and provides them with the ability to form lamellar structures that can facilitate functional sliding. Moreover, the friction coefficient can significantly change for a given phospholipid bilayer so it leads to a lamellar-repulsive mechanism under highly charged conditions. After this, it is quickly transformed to result in stable low-friction conditions.

show abstract

Section: Lamellar-repulsive Lubrication Mechanism Between Cartilage/csupporting

confidence: 86%

Section: Lamellar-repulsive Lubrication Mechanism Between Cartilage/csupporting

confidence: 86%

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Zooming in on the cartilage level the respective boundary lubricant is claimed to consist of the surface-active phospholipids and/or of macromolecular components of the synovial fluid. 2,11,[18][19][20][21][22][23][24][25][26][27][28] For a very simplified model system comprising solid-supported oligolamellar stacks of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayer membranes against water and solutions of HA in water we observed a tremendous swelling (by a factor of ~4) and a stabilization of the lipid linings upon incubation with HA at 39 °C, i.e. well above the main phase transition temperature, , of the lipids.…”

Section: Introductionmentioning

confidence: 99%

Surface-Active Lipid Linings under Shear Load—A Combined in-Situ Neutron Reflectivity and ATR-FTIR Study

et al. 2015

View full text Add to dashboard Cite

We study shear effects in solid-supported lipid membrane stacks by simultaneous combined in-situ neutron reflectivity (NR) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). The stacks mimic the terminal surface-active phospholipid (SAPL) coatings on cartilage in mammalian joints. Piles of 11 bilayer membranes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) are immobilized at the interface of the solid silicon support and the liquid D2O backing phase. We replace the natural hyaluronic acid (HA) component of synovial fluid by a synthetic substitute, namely, poly(allylamine hydrochloride) (PAH), at identical concentration. We find the oligolamellar DMPC bilayer films strongly interacting with PAH resulting in a drastic increase of the membranes d spacing (by a factor of ∼5). Onset of shear causes a buckling-like deformation of the DMPC bilayers perpendicular to the applied shear field. With increasing shear rate we observe substantially enhanced water fractions in the membrane slabs which we attribute to increasing fragmentation caused by Kelvin-Helmholtz-like instabilities parallel to the applied shear field. Both effects are in line with recent theoretical predictions on shear-induced instabilities of lipid bilayer membranes in water (Hanasaki, I.; Walther, J. H.; Kawano, S.; Koumoutsakos, P. Phys. Rev. E 2010, 82, 051602). With the applied shear the interfacial lipid linings transform from their gel state Pβ' to their fluid state Lα. Although in chain-molten state with reduced bending rigidity the lipid layers do not detach from their solid support. We hold steric bridging of the fragmented lipid bilayer membranes by PAH molecules responsible for the unexpected mechanical stability of the DMPC linings.

show abstract

“…At this time, the joint's movements become severely limited, often causing great pain to the patients. Wear of articular cartilage is an important symptom of OA [32] and the severity of wear is often used for OA assessment.…”

Section: Oa Causes Symptoms and Existing Diagnosis Techniquesmentioning

confidence: 99%

Wear in human knees

Wang

Peng

2015

Biosurface and Biotribology

View full text Add to dashboard Cite

Wear occurs in natural knee joints and plays a pivotal factor in causing articular cartilage degradation in osteoarthritis (OA) processes. Wear particles are produced in the wear process and get involved in inflammation of human knees. This review presents progresses in the mechanical and surface morphological studies of articular cartilages, wear particles analysis techniques for wear studies and investigations of human knee synovial fluid in wear of human knees. Future work is also included for further understanding of OA symptoms and their relations which may shed light on OA causes. & 2015 Southwest Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

show abstract

Liposomes as potential biolubricant additives for wear reduction in human synovial joints

Cited by 30 publications

References 26 publications

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Surface-Active Lipid Linings under Shear Load—A Combined in-Situ Neutron Reflectivity and ATR-FTIR Study

Wear in human knees

Contact Info

Product

Resources

About