Liposomes as Carrier of Methyl-GAG

Arndt, Dieter; Fichtner, Iduna; Nissen, Eberhard

doi:10.1159/000226490

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Its anticancer agent properties were recently highlighted, but the molecules of this class have solubility in aqueous solutions that can be considered low [8]. Studies the association of this class the compound with some carriers as cyclodextrin, liposomes or linear polymers were few reported [9].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity: Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

Silva¹,

Oliveira²,

Candido³

et al. 2020

JBNB

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Aminoguanidine hydrazones (AGHs) are a class of compounds that have interesting pharmacological activities. They are derived from the same chemical group as aminoguanidine, so it has mixed properties (receptor and donor) in the formation of hydrogen bonds. Its anticancer agent properties were recently highlighted, but the molecules of this class have solubility in aqueous solutions that can be considered low. The identification of this class, by a simple, sensitive and low-cost technique, such as electrochemistry, which also allows the evaluation of its solubilization process through agents such as PAMAM dendrimer is the main objective of the work described here. The electrochemical response of the LQM10 (AGH derivative) was evaluated, as well as its behavior in different electrochemical sensors. Electrochemical experiments were performed in buffered (phosphate at pH 7.02 and acetate at 4.5). LQM10 has a reversible oxidation peak with a potential of +0.22 V. It was efficiently detected in different electrodes tested (glass carbon/CNT, glass carbon/CNT/PAMAM), which proves the viability of the electrodes for various analyses and has the determination of the apparent constant association, indicating its interaction with the analysis that is higher in the presence of the PAMAM encapsulating agent. This was corroborated by the results for the modified gold electrode with MUA and PAMAM. The sum of the results shows the possibility of electrochemically evaluating the Aminoguanidine hydrazone derivative, the viability of electrodes employed and the greater so-How to cite this paper:

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Section: Introductionmentioning

confidence: 99%

Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity: Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

Silva¹,

Oliveira²,

Candido³

et al. 2020

JBNB

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Liposomal Bleomycin: Increased Therapeutic Activity and Decreased Pulmonary Toxicity in Mice

et al. 2001

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Conventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bleomycin enhanced strongly the antitumor activity against P388 leukemia and the Lewis lung carcinoma. This effect was clearly dependent on the size and lipid composition of the bleomycin-containing liposomes. The therapeutic effects were nearly equal for liposomal and free bleomycin in the B16 melanoma. The partial replacement of phosphatidylcholine by alkylphospholipids and the inclusion of polyethylene glycol modified lipids for sterical stabilization did not further improve the therapeutic efficacy but increased, in some cases, the toxicity of liposomes. Bleomycin-induced lung injury was not observed if liposomal bleomycin was administered.

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Liposomes as Carrier of Methyl-GAG

Cited by 2 publications

References 3 publications

Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity: Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity: Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

Liposomal Bleomycin: Increased Therapeutic Activity and Decreased Pulmonary Toxicity in Mice

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