Liposomes and phytosomes: Nanocarrier systems and their applications for the delivery of phytoconstituents

Dutt, Yogesh; Pandey, Ramendra Pati; Dutt, Mamta; Gupta, Archana; Vibhuti, Arpana; Raj, V. Samuel; Chang, Chung-Ming; Priyadarshini, Anjali

doi:10.1016/j.ccr.2023.215251

Cited by 11 publications

(4 citation statements)

References 198 publications

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“…They are able to minimize enzymatic degradation in the gastrointestinal tract, prevent hepatic biotransformation into inactive metabolites, attenuate toxicity at the site of action, and deliver phytochemical constituents and internalize them into the target cell. [28] They are composed of phospholipids capable of encapsulating hydrophilic and lipophilic constituents, thanks to their cellular self-assembly behavior. They can be classified as unilamellar or multilamellar, being related to the amount of concentric layers of phospholipids.…”

Section: Liposomesmentioning

confidence: 99%

“…Liposomes are systems with great potential for the release of plant extracts due to their biodegradable nature and ability to transport drugs of different polarities. They are able to minimize enzymatic degradation in the gastrointestinal tract, prevent hepatic biotransformation into inactive metabolites, attenuate toxicity at the site of action, and deliver phytochemical constituents and internalize them into the target cell [28] . They are composed of phospholipids capable of encapsulating hydrophilic and lipophilic constituents, thanks to their cellular self‐assembly behavior.…”

Section: Nanosystemsmentioning

confidence: 99%

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Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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Because of the increasing demand for natural products, the development of nanoformulations containing natural active ingredients requires in‐depth knowledge of the substances used, methods of obtaining, and stability profiles to ensure product quality, efficacy, and safety. Considering this, the bibliography of the last five years presented in databases (PubMed and Science Direct) was discussed in this work, discussing the study with medicinal plants to obtain active metabolites with therapeutic properties, as well as the different nano‐systems responsible for carrying these molecules. Due to the wealth of biodiversity found in the world, many species are submitted to the extraction process for several purposes. However, identifying, classifying, and quantifying the constituents of herbal matrices are crucial steps to verify their therapeutic potential. In addition, knowing the techniques of production and elaboration of nanotechnology products allows the optimization of the incorporation of herbal extracts as an innovation target. For studies to be successful, it is necessary to exhaust experimental results that guarantee the efficacy, safety, and quality of natural nanosystems, with the objective of obtaining reliable answers in nanotechnology therapy.

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Section: Liposomesmentioning

confidence: 99%

Section: Nanosystemsmentioning

confidence: 99%

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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“…Particularly, the self-assembly approach holds great promise for designing effective delivery systems. , Liposomes are one of the drug delivery systems that are frequently used as a carrier for the lipophilic and hydrophilic antioxidant agents to evaluate their antioxidant activities . Moreover, liposomes are also used as an efficient delivery system for water-soluble (e.g., glutathione, N-acetylcysteine, and quercetin) and lipid-soluble (e.g., tocopherol and CoQ10) antioxidant medicines to various organs and tissues for the treatment of oxidative stress-associated damage. − Recently, there has been a growing interest in exploring innovative approaches to enhance drug delivery systems for improved bioavailability and therapeutic efficacy. , Among these approaches, the incorporation of bioactive compounds into the structure of liposomes has gained significant attention . Liposomes, as versatile and biocompatible nanocarriers, have shown great potential for encapsulating a wide range of therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

“… 6 Moreover, liposomes are also used as an efficient delivery system for water-soluble (e.g., glutathione, N-acetylcysteine, and quercetin) and lipid-soluble (e.g., tocopherol and CoQ10) antioxidant medicines to various organs and tissues for the treatment of oxidative stress-associated damage. 7 − 8 9 10 Recently, there has been a growing interest in exploring innovative approaches to enhance drug delivery systems for improved bioavailability and therapeutic efficacy. 11 , 12 Among these approaches, the incorporation of bioactive compounds into the structure of liposomes has gained significant attention.…”

Section: Introductionmentioning

confidence: 99%

Liposome Nanocarriers Based on γ Oryzanol: Preparation, Characterization, and In Vivo Assessment of Toxicity and Antioxidant Activity

Jasim,

Albukhaty,

Sulaiman

et al. 2024

ACS Omega

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The present study aimed to develop and characterize liposome nanocarriers based on γ oryzanol and evaluate their potential in vitro and in vivo toxicity and antioxidant effects. The liposomes were physicochemically characterized using various techniques, including dynamic light scattering (DLS) for size and polydispersity index (PDI) measurements and ζ-potential analysis. The in vitro toxicity assessments were performed using hemolysis and MTT assays on the HS5 cell line. In vivo, acute oral toxicity was evaluated by using LD 50 assays in mice. Additionally, antioxidant activity was assessed through biochemical analysis of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and liver tissue catalase, malondialdehyde (MDA), and glutathione (GSH) levels. The results revealed that the liposomes exhibited a uniform and spherical morphology with suitable physicochemical properties for drug delivery applications. The in vitro cytotoxicity and hemolysis assays and the in vivo LD 50 experiment indicated the potential safety of γ oryzanol liposomes, especially at lower concentrations. In addition, the assessment of liver enzymes, i.e., ALT and AST, and the antioxidant markers further revealed the safety of the formulation, particularly for the liver as a highly sensitive soft organ. Overall, the liposome nanocarriers based on γ oryzanol were successfully formulated and expressed potential safety, supporting their application for the purposes of drug delivery and therapeutic interventions, particularly for hepatocellular and antioxidant therapies; however, further investigations for preclinical and clinical studies could be the future prospects for liposome nanocarriers based on γ oryzanol to explore the safety and efficacy of these nanocarriers in various disease models and clinical settings.

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Phytochemical-Based Formulations for Biomedical Applications

Ramesh,

Palaniappan

2024

Medicinal Applications of Phytopharmaceuticals

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Liposomes and phytosomes: Nanocarrier systems and their applications for the delivery of phytoconstituents

Cited by 11 publications

References 198 publications

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Liposome Nanocarriers Based on γ Oryzanol: Preparation, Characterization, and In Vivo Assessment of Toxicity and Antioxidant Activity

Phytochemical-Based Formulations for Biomedical Applications

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