Liposomes and Niosomes as Topical Drug Delivery Systems

Abstract

The skin acts as a major target as well as a principle barrier for topical/transdermal (TT) drug delivery. The stratum corneum plays a crucial role in barrier function for TT drug delivery. Despite major research and development efforts in TT systems and the advantages of these routes, low stratum corneum permeability limits the usefulness of topical drug delivery. To overcome this, methods have been assessed to increase permeation. One controversial method is the use of vesicular systems, such as liposomes and niosomes, whose effectiveness depends on their physicochemical properties. This review focuses on the effect of liposomes and niosomes on enhancing drug penetration, and defines the effect of composition, size and type of the vesicular system on TT delivery.

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

“…2 However, these investigated delivery systems show their own drawbacks. Frequently reported disadvantages of colloidal carriers such as liposomes, micro and nanoemulsions, nanocapsules, nanosponges, and polymeric nanoparticles include burst drug release in orallyadministered drugs due to its rapid degradation by the pH of the stomach or by intestinal enzymes and bile salts, limited physical and chemical stability during storage, [3][4][5][6][7][8] difficulty in large-scale production, residues from organic solvents used in preparation of the carriers, some susceptibilities in polymer toxicity, [8][9][10] and too many more to mention. All of these drawbacks suggest that these colloidal drug delivery systems are not ideal for use as drug carriers.…”

Effect of permeation enhancers on the iontophoretic transport of metoprolol tartrate and the drug retention in skin

“…This is because the drug retention within the skin may hamper the efficient absorption by the skin and permeation across the skin, as the drug reservoir in tissues is likely to increase the skin barrier resistance. The drug reservoir in the skin is most commonly observed when the drug is delivered from vesicular systems or the drug-complex with polymers or the ion pairs (Green et al, 1989;Doliwa et al, 2001;Choi & Maibach, 2005;Cosco et al, 2008). Few reports also exist with the drug depot formation during transdermal iontophoresis (Banga & Chien, 1993;Sachdeva et al, 2010).…”

The Effect of Niosomal System (Span 60-Cholesterol) on Diclofenac Sodium Preparation Characteristics and Diclofenac Sodium Preparation of Hydroxypropyl Cellulose Gel Base (HPC)

“…The structure was act as a "protector" from the water in the middle and some hydrophilic heads. Cholesterol yields rougher bilayer and decrease niosome leakage risk (Choi & Maibach, 2005). Niosomes also gave better delivery for the drugs (Suresh and Kerunath, 2015).…”