Liposomes: A Review of Manufacturing Techniques and Targeting Strategies

Maherani, Behnoush; Arab‐Tehrany, Elmira; Mozafari, M. R.; Gaiani, Claire; Linder, Michel

doi:10.2174/157341311795542453

Cited by 296 publications

(203 citation statements)

References 180 publications

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“…Menurut Maherani, dkk. [9] efisiensi enkapsulasi liposom bergantung pada kekakuan membran bilayer liposomnya. Panjang rantai asil akan mempengaruhi ketebalan dan interaksi antar rantai asil di dalam membran.…”

Section: Analisis Efisiensi Enkapsulasi Vitamin Cunclassified

Studi Pendahuluan tentang Enkapsulasi Vitamin C dalam Liposom Kelapa (Cocos nucifera L.)

2017

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Section: Analisis Efisiensi Enkapsulasi Vitamin Cunclassified

Studi Pendahuluan tentang Enkapsulasi Vitamin C dalam Liposom Kelapa (Cocos nucifera L.)

2017

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“…It can be adsorbed on surface of membrane, entrapped in lipid bilayer, encapsulated in inner aqueous core, attached between polar head or supported by a hydrophobic tail (Maherani et al, 2011). Method of preparation and composition of lipid can also influence the entrapment efficiency.…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs

Sailor¹,

Seth²,

Parmar³

et al. 2015

J App Pharm Sci

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The present study demonstrates the application of 3 2 full factorial design for optimization of berberine loaded liposome for oral administration. Thin film hydration method was used to prepare liposome and optimization was done by 3 2 full factorial designs combined with desirability function. Nine formulations were prepared by using different drug : lipid and soyphosphatidylcholine : cholesterol (SPC:CHOL) ratios and evaluated for entrapment efficiency and vesicle size. The statistical validity of model was done by analysis of variance (ANOVA). Response surface graph and contour plots were used to understand the effect of variables on responses. The optimized formulation with 0.782 desirability value was prepared and evaluated for responses. The results of entrapment efficiency and vesicle size were found to be very close with the predicted values. In addition, an optimized formulation was also characterized for zeta potential, in vitro drug release and morphology. The formulation was found to be spherical shape with an average diameter of 0.823 nm and -1.93 mV zeta potential and also shows sustained release pattern. These results support the fact that 3 2 full factorial designs with desirability function could be effectively used in optimization of berberine loaded liposome.

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“…Most liposome production methods use organic solvent to form and deposit planar lipid bilayers due to insolubility of lipids in aqueous solution [13]. The planar lipid bilayers are mechanically agitated using extrusion or ultrasound, and broken into small free-standing pieces, which then tend to self-assemble into spherical liposomes to reduce their free energy [14e18].…”

Section: Introductionmentioning

confidence: 99%

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

Yoon

Jeong

et al. 2015

Biomaterials

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We propose a microfluidic system that generates nanovesicles (NVs) by slicing living cell membrane with microfabricated 500 nm-thick silicon nitride (SixNy) blades. Living cells were sliced by the blades while flowing through microchannels lined with the blades. Plasma membrane fragments sliced from the cells self-assembled into spherical NVs of ~100-300 nm in diameter. During self-assembly, the plasma membrane fragments enveloped exogenous materials (here, polystyrene latex beads) from the buffer solution. About 30% of beads were encapsulated in NVs, and the generated NVs delivered the encapsulated beads across the plasma membrane of recipient cells, but bare beads could not penetrate the plasma membrane of recipient cells. This result implicates that the NVs generated using the method in this study can encapsulate and deliver exogenous materials to recipient cells, whereas exosomes secreted by cells can deliver only endogenous cellular materials.

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Liposomes: A Review of Manufacturing Techniques and Targeting Strategies

Cited by 296 publications

References 180 publications

Studi Pendahuluan tentang Enkapsulasi Vitamin C dalam Liposom Kelapa (Cocos nucifera L.)

Studi Pendahuluan tentang Enkapsulasi Vitamin C dalam Liposom Kelapa (Cocos nucifera L.)

Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

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