Liposome-templated gold nanoparticles for precisely temperature-controlled photothermal therapy based on heat shock protein expression

Xia, Yuqiong; Li, Cairu; Cao, Jianxia; Chen, Zhao‐Xu; Wang, Jun; Wu, Yufeng; Zhang, Xianghan

doi:10.1016/j.colsurfb.2022.112686

Cited by 11 publications

(9 citation statements)

References 36 publications

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“… 66 In order to realize the precise management of HSPs expression, Xia et al made use of liposome-templated gold nanoparticles which had low-temperature fluctuation (smaller than 1°C) to probe the expression of HSP70 and HSP90 versus temperature (42,45,47,50,55°C) in 4T1 tumor-bearing Bal/b mice ( Figure 2b ). 39 Quantitative real time PCR analysis showed that the maximum expression of HSP70 and HSP90 were at 42°C and 47°C(3.9-fold and 2.3-fold compared to PBS group), similar to the in vitro results of Mantso’s work, 66 while the minimal expression of HSP70 and HSP90 were both almost at 55°C(0.5-fold compared to PBS group). Interestingly, it found that the expression of HSP70 was more susceptible to temperature changes than HSP90, so the inhibition of HSP70 might be more beneficial to tumor treatment.…”

Section: Mptt Plays a Leading Role In Tumor Therapysupporting

confidence: 71%

“…112686, Copyright 2022, with permission from Elsevier. 39 ( c ) Schematic showing the synthesis of PBLM@CCM and its application for multimodal imaging-guided and multimodal-targeted mPTT. Reprinted from J Control Release , 347, Shu X, Chen Y, Yan P, et al Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging.…”

Section: Mptt Plays a Leading Role In Tumor Therapymentioning

confidence: 99%

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Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

He¹,

Zhang²,

Tian³

et al. 2023

IJN

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With the booming development of nanomedicine, mild photothermal therapy (mPTT, 42–45°C) has exhibited promising potential in tumor therapy. Compared with traditional PTT (>50°C), mPTT has less side effects and better biological effects conducive to tumor treatment, such as loosening the dense structure in tumor tissues, enhancing blood perfusion, and improving the immunosuppressive microenvironment. However, such a relatively low temperature cannot allow mPTT to completely eradicate tumors, and therefore, substantial efforts have been conducted to optimize the application of mPTT in tumor therapy. This review extensively summarizes the latest advances of mPTT, including two sections: (1) taking mPTT as a leading role to maximize its effect by blocking the cell defense mechanisms, and (2) regarding mPTT as a supporting role to assist other therapies to achieve synergistic antitumor curative effect. Meanwhile, the special characteristics and imaging capabilities of nanoplatforms applied in various therapies are discussed. At last, this paper puts forward the bottlenecks and challenges in the current research path of mPTT, and possible solutions and research directions in future are proposed correspondingly.

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Section: Mptt Plays a Leading Role In Tumor Therapysupporting

confidence: 71%

Section: Mptt Plays a Leading Role In Tumor Therapymentioning

confidence: 99%

Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

He¹,

Zhang²,

Tian³

et al. 2023

IJN

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show abstract

“…Thus, HSP70 inhibitors, such as triptolide which enhanced cellular radiosensitivity by inhibiting HSPA5 to trigger apoptosis and induce G 2 /M cell cycle arrest in nasopharyngeal carcinoma, can be used as radiosensitizers in radiation therapy [ 177 ]. Of note, the level of HSP70 was also upregulated in cancer cells treated with heat or light, leading to the low therapeutic efficiency in tumors [ 178 , 179 ]. Synergistic photothermal therapy (PTT), photodynamic therapy (PDT), or radiofrequency ablation (RFA) with HSP70 inhibitors, a combination treatment which has already shown improved efficiency than PTT, PDT, or RFA used alone in liver cancer, breast cancer, cervical cancer, and pancreatic cancer, offers an immediate translational potential in the management of numerous cancers [ 179 , 180 , 181 , 182 , 183 ].…”

Section: Targeting Hsp70 In Cancer Therapymentioning

confidence: 99%

HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances

et al. 2023

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The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expressed and may serve as prognostic markers in many types of cancers. HSP70s are also involved in most of the molecular processes of cancer hallmarks as well as the growth and survival of cancer cells. In fact, many effects of HSP70s on cancer cells are not only related to their chaperone activities but rather to their roles in regulating cancer cell signaling. Therefore, a number of drugs directly or indirectly targeting HSP70s, and their co-chaperones have been developed aiming to treat cancer. In this review, we summarized HSP70-related cancer signaling pathways and corresponding key proteins regulated by the family of HSP70s and partner chaperons. In addition, we also summarized various treatment approaches and progress of anti-tumor therapy based on targeting HSP70 family proteins.

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“…They adjusted the photothermal temperature by adjusting the laser power density to achieve precisely controlled mildtemperature PTT, which achieved a 75% tumor suppression rate when combined with HSP inhibitors. 97 However, HSP inhibitors are toxic; thus, their usage and dosage are significantly limited, 98 requiring PTAs to act in a shorter period. AuNCs can penetrate tumors rapidly and deeply, shortening the time required for PTT.…”

Section: Auncs In Combination Therapymentioning

confidence: 99%

“…Xia et al quantified the expression of HSP in liposome-templated AuNCs at different photothermal temperatures and found that the expression of HSP 70 was the least at 47 °C. They adjusted the photothermal temperature by adjusting the laser power density to achieve precisely controlled mild-temperature PTT, which achieved a 75% tumor suppression rate when combined with HSP inhibitors …”

Section: Significant Phototherapy Potential Of Auncs To Be Exploitedmentioning

confidence: 99%

A Review on Gold Nanoclusters for Cancer Phototherapy

Yang,

Guo

et al. 2023

ACS Appl. Bio Mater.

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Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has been extensively studied in recent years because of its noninvasive properties, high efficiency, improved selectivity, and reduced side effects. Gold nanoclusters (AuNCs) have the advantages of high biocompatibility, high biosafety, excellent photoresponse, and high tumor penetration ability. This review analyzes the use of AuNCs in tumor phototherapy in recent years from three aspects, namely, AuNCs in PDT, AuNCs in PTT, and AuNCs in combination therapy, and presents the high potential of AuNCs in cancer phototherapy. This review aims to provide readers with the unique advantages, diversified application approaches, and bright application prospects of AuNCs in phototherapy and to provide insights into strategies for applying AuNCs to tumor phototherapy.

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Liposome-templated gold nanoparticles for precisely temperature-controlled photothermal therapy based on heat shock protein expression

Cited by 11 publications

References 36 publications

Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances

A Review on Gold Nanoclusters for Cancer Phototherapy

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