Liposome quercetin enhances the ablation effects of microwave ablation in treating the rabbit VX2 liver tumor model

Li, Hao; Chen, Pengfei; Wang, Manzhou; Wang, Wenhui; Li, Fangzheng; Han, Xinwei; Ren, Jianzhuang; Duan, Xuhua

doi:10.1080/02656736.2021.2023767

Cited by 8 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wan et al further found that high expression of HSP70 and HIF-1a could be found in the residual tumor cells around the ablation site (88). Li et al also found that MWA can promote the expression of HIF-1a, thereby promoting angiogenesis by promoting the overexpression of vascular endothelial growth factor (VEGF), and accelerating the progression of tumor tissue invasion (89). In terms of mechanism, Chen et al demonstrated that sublethal heat stress inhibited HIF-1a degradation by inducing O-linked-N-acetylglucosaminylation (O-GlcNAcylation) to upregulate HIF-1a expression in hepatocellular carcinoma (HCC) cells (90).…”

Section: Mwa Might Regulate the Ferroptosis Of Cancer Cells By Hifmentioning

confidence: 99%

Crosstalk between microwave ablation and ferroptosis: The next hot topic?

et al. 2023

View full text Add to dashboard Cite

Microwave ablation has been one form of thermal ablation in treatments for many tumors, which can locally control unresectable tumors. Ferroptosis is iron-dependent cell death caused by the cumulative reactive oxygen species and lipid peroxidation products. Recently, increasing evidence has shown that ferroptosis might play a vital role in MWA-induced tumor suppression. In this article, we briefly illustrate the concept of ferroptosis, the related signal pathways and inducers, the basic principle of microwave ablation in killing tumors, and the key molecules released after microwave ablation. Then, we describe the cross-talking molecules between microwave ablation and ferroptosis, and discussed the potential mechanism of microwave ablation-induced ferroptosis. This review explores the therapeutic target of ferroptosis in enhancing the systemic antitumor effect after microwave ablation, providing theoretical support in combinational microwave ablation with pro-ferroptosis therapy.

show abstract

Section: Mwa Might Regulate the Ferroptosis Of Cancer Cells By Hifmentioning

confidence: 99%

Crosstalk between microwave ablation and ferroptosis: The next hot topic?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Tumor ablation is a minimally invasive surgical procedure for solid cancer treatment. Investigations on microwave ablation have shown that the infusion of liposomal QUR on liver VX2 tumors can remarkably improve the sensitivity of microwave radiation, blocking angiogenesis and the excessive proliferation of residual tumors, decreasing metastasis, and prolonging the survival period of experimental animals (Li, Chen, Wang, et al, 2022).…”

Section: Liposomesmentioning

confidence: 99%

Nanophytomedicine: A promising practical approach in phytotherapy

Sardarabadi,

Darvishi,

Zohrab

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

The long and rich history of herbal therapeutic nutrients is fascinating. It is incredible to think about how ancient civilizations used plants and herbs to treat various ailments and diseases. One group of bioactive phytochemicals that has gained significant attention recently is dietary polyphenols. These compounds are commonly found in a variety of fruits, vegetables, spices, nuts, drinks, legumes, and grains. Despite their incredible therapeutic properties, one challenge with polyphenols is their poor water solubility, stability, and bioavailability. This means that they are not easily absorbed by the body when consumed in essential diets. Because of structural complexity, polyphenols with high molecular weight cannot be absorbed in the small intestine and after arriving in the colon, they are metabolized by gut microbiota. However, researchers are constantly working on finding solutions to enhance the bioavailability and absorption of these compounds. This study aims to address this issue by applying nanotechnology approaches to overcome the challenges of the therapeutic application of dietary polyphenols. This combination of nanotechnology and phytochemicals could cause a completely new field called nanophytomedicine or herbal nanomedicine.

show abstract

“…Furthermore, Li et al examined whether liposomal quercetin (LQ) may improve the outcomes of microwave ablation (MVA) while treating the rabbit VX2 liver tumor model. The results indicated that the preparative infusion of LQ can significantly improve the effects of MWA on VX2 liver tumors in rabbits, extend their survival time by inhibiting the expression of HSP70 and HIF-1 in the residual tumor, and prevent the excessive growth of the residual tumor by lowering metastasis ( Figure 2 ) [ 87 ].…”

Section: Lipid-based Carrier Systemsmentioning

confidence: 99%

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles

et al. 2023

View full text Add to dashboard Cite

Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Based on the studies, high hydrophobic properties of the aforementioned compounds limit their bioavailability inside the human body and restrict their wide application. Nanoscale formulations such as solid lipid nanoparticles, liposomes, and other types of lipid-based delivery systems have been introduced to overcome the above-mentioned challenges. This approach allows the aforementioned hydrophobic therapeutic compounds to be encapsulated between hydrophobic structures, resulting in improving their bioavailability. The above-mentioned enhanced delivery system improves delivery to the targeted sites and reduces the daily required dosage. Lowering the required daily dose improves the performance of the drug by diminishing its side effects on non-targeted tissues. The present study aims to highlight the recent improvements in implementing lipid-based nanocarriers to deliver flavonolignans and flavonoids.

show abstract

Liposome quercetin enhances the ablation effects of microwave ablation in treating the rabbit VX2 liver tumor model

Cited by 8 publications

References 22 publications

Crosstalk between microwave ablation and ferroptosis: The next hot topic?

Crosstalk between microwave ablation and ferroptosis: The next hot topic?

Nanophytomedicine: A promising practical approach in phytotherapy

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles

Contact Info

Product

Resources

About