Liposome–Gold Nanorod Hybrids for High-Resolution Visualization Deep in Tissues

Lozano, Neus; Al-Jamal, Wafa' T; Taruttis, Adrian; Bézière, Nicolas; Burton, Neal C.; Bossche, Johan Van den; Mazza, Mariarosa; Herzog, Eva; Ntziachristos, Vasilis; Kostarelos, Kostas

doi:10.1021/ja304499q

Cited by 78 publications

(74 citation statements)

References 14 publications

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“…The core can also provide magnetic and fluorescence property, depending on the core composition. [70][71][72] Wrapping a PC lipid layer on an inorganic NP can make the surface less sticky (anti-fouling), and thus increase biocompatibility of the core. A good example incorporating all these features was reported by Brinker and coworkers ( Figure 10B).…”

Section: Applicationsmentioning

confidence: 99%

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Liu

2016

Langmuir

124

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Section: Applicationsmentioning

confidence: 99%

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Liu

2016

Langmuir

124

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“…High-resolution visualization of double-labeled liposomes in deep tissues was previously performed by multispectral optoacoustic tomography (MSOT). [60] However, the TPLSM enables highly detailed studies on the impact of the extracellular matrix (ECM) on the distribution of drugs and drug delivery systems within tumors, and it facilitates studies in which therapies modulating the ECM are being evaluated. Importantly, for such 3D TPLSM studies, fluorophores with wavelengths below ~600 nm have to be employed (because of the principles of two-photon excitation), underlining the importance of labeling nanomedicines with two different fluorophores.…”

Section: Ex Vivo Analysis Of Tumor Accumulation and Penetration Usingmentioning

confidence: 99%

Fluorophore Labeling of Core-Crosslinked Polymeric Micelles for Multimodal In Vivo and Ex Vivo Optical Imaging

Shi

Kunjachan

et al. 2015

Nanomedicine (Lond.)

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Aim-To enable multimodal in vivo and ex vivo optical imaging of the biodistribution and tumor accumulation of core-crosslinked polymeric micelles (CCPM).Materials & Methods-mPEG-b-p(HPMAm-Lac)-based polymeric micelles, core-crosslinked via cystamine and covalently labeled with two fluorophores (Dy-676/488) were synthesized. The CCPM were intravenously injected in CT26 tumor-bearing mice.Results-Upon intravenous injection, the CCPM accumulated in CT26 tumors reasonably efficiently, with values reaching ~4 %ID at 24 hours. Ex vivo TPLSM confirmed efficient extravasation of the iCCPM out of tumor blood vessels and deep penetration into the tumor interstitium.Conclusions-CCPM were labeled with multiple fluorophores, and they exemplify that combining different in vivo and ex vivo optical imaging techniques is highly useful for analyzing the biodistribution and tumor accumulation of nanomedicines.

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“…119 Current synthetic methods can be used to synthesize NPs with absorption bands in the range where OI operates. For instance, gold nanoprisms and nanorods, 37,120 whose plasmon band can be adjusted along the NIR by chemical design, have been used as OI contrast agents. Actually, expanding the excitation sources used by OI into the SWIR will improve the possibilities of this technique owing to deeper tissue penetration.…”

Section: Optoacoustic Imagingmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Liposome–Gold Nanorod Hybrids for High-Resolution Visualization Deep in Tissues

Cited by 78 publications

References 14 publications

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Fluorophore Labeling of Core-Crosslinked Polymeric Micelles for Multimodal In Vivo and Ex Vivo Optical Imaging

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

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