Liposome encapsulation of curcumin: Physico-chemical characterizations and effects on MCF7 cancer cell proliferation

Preparation and Characterization of Nanoliposomal Beta- Cryptoxanthin and its Effect on Proliferation and Apoptosis in Human Leukemia Cell Line K562

“…In this case, similar observations have been reported in some previous studies with other natural plant products such as curcumin [15], epigallocatechin-3-gallate [16], celastrol [17], tea polyphenol [18], berberine [19] and gossypol [20] in various cancer cell lines. Therefore, betacryptoxanthin and other effective plant-derived agents, in particular in loaded form, could be considered as a promising strategy for developing anticancer drugs.…”

“…Our results showed that anti-proliferation of beta-cryptoxanthin-loaded nanoliposomes against K562 cells was higher than those of free beta-cryptoxanthin. Several hypotheses, including increased water suspensibility and penetration of plant-derived compounds into cells may explain the mechanism of enhanced anticancer efficacies of these nanovesicle formulations [15][16][17][18][19][20]. When nanocarriers such as nanoliposomes were used in vitro, they can interact with the cancer cell membranes, and therefore they can selectively deliver drugs to the cancer cells [19,20].…”

Inhibition of telomerase activity and cell growth by free and nanoliposomal forms of punicalagin in human leukemia cell line K562

“…Similar anticancer activity had been reported in previous investigations with other liposomal natural plant products such as celastrol [25], epigallocatechin-3-gallate [24], gossypol [26], wagonin [27], berberin [28], curcumin [29] and tea polyphenol [30] in various cancer cell lines. Therefore, punicalagin and other effective plantderived agents in the free and encapsulated forms may be considered as promising strategy to develop new anticancer drugs.…”

“…Several hypotheses, including increased penetration of plant-derived compounds into cells and stability of encapsulated materials may explain the mechanism of enhanced anticancer efficacies of this nanoliposomal formulation [25][26][27][28][29][30]. Our data showed a significant and positive correlation between telomerase inhibition and induction of apoptosis.…”

Curcumin Induces Apoptosis in SGC-7901 Gastric Adenocarcinoma Cells via Regulation of Mitochondrial Signaling Pathways

“…Curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione), derived from the rhizome of the plant Curcuma longa L, has been used for thousands of years in Asia countries as a food additive, cosmetic, and as a traditional herbal medicine (Jiang et al, 2014;Shoji et al, 2014 shown that curcumin possessed the anticarcinogenic properties by modulating various mechanisms linked with the development and progression of cancer (Hasan et al, 2014). Apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies (Wong, 2011;Li et al, 2013;Singh et al, 2013;Gopal et al, 2014;.…”