Liposome-based nanocapsules for the controlled release of dietary curcumin: PDDA and silica nanoparticle-coated DMPC liposomes enhance the fluorescence efficiency and anticancer activity of curcumin

Othman, Alaa K.; Kurdi, Riham El; Badran, Adnan; Mesmar, Joelle; Baydoun, Elias; Patra, Digambara

doi:10.1039/d2ra00071g

Cited by 23 publications

(9 citation statements)

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Section: Resultsmentioning

confidence: 99%

“…The absorption maximum of curcumin at 430 nm was shifted to 403 nm, and that of CP at 265 was shifted to 275 nm. The observed shift in curcumin absorption maximum may be due to the complex formation with PL, 31 and the shift observed in CPs can be due to the variations in the microenvironment of the aromatic side chains. 29,30 Fluorescence spectra of C95 and CCL were recorded at an excitation wavelength of 420 nm, and the corresponding emission was observed at 540 nm for C95 and at 527 nm for CCL (Figure 2e).…”

Section: Preparation and Characterizationmentioning

confidence: 99%

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Two-Stage Supramolecular Self-Assembly-Directed Collagen-Peptide-Decorated Liposomal Complexes of Curcumin Microspheres with Enhanced Solubility and Bioavailability

M¹,

Balakrishnan²,

Joseph³

et al. 2023

ACS Omega

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Green formulations of phytonutrients with enhanced solubility and bioavailability are of great significance in nutrition therapy. In the present contribution, we hypothesized that the collagen peptides could be a safe, natural, food-grade, and costeffective functional agent for the surface decoration and stabilization of liposomes in powder form and hence a "green" solution for the oral delivery of phytonutrients. The present study reports a two-stage supramolecular self-assembly-directed process for the preparation of collagen peptide-decorated liposomal complexes of curcumin (CCL) [10% (w/w)] as microspheres (125 ± 25 μm) with improved solubility (1.46 × 10 5 -fold) and sustained-release properties under gastrointestinal pH conditions. The molecular selfassembly of collagen peptides around the lipid bilayers and the various noncovalent interactions and conformational changes leading to the supramolecular assembly to act as a matrix for the encapsulation of lipid vesicles of curcumin were clear from the spectroscopic studies (UV−vis, fluorescence, FTIR, and circular dichroism). Further investigation of pharmacokinetics following a randomized double-blinded controlled trial on healthy volunteers (n = 15) demonstrated that the oral administration of 2.5 g of CCL sachet (250 mg of curcumin) enhanced the plasma concentration (C max : 118 vs. 4.3 ng/mL), the elimination half-life (4.2 vs. 0.7 h), and bioavailability as per the area under the curve over 12 h [AUC 0−12h (CCL) = 506•8 vs. AUC 0−12h (C95) = 9.47 (53fold)], when the plasma concentration of curcumin was estimated with triple quadruple tandem mass spectrometry (UPLC-ESI-MS/ MS).

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Section: Resultsmentioning

confidence: 99%

Section: Preparation and Characterizationmentioning

confidence: 99%

Two-Stage Supramolecular Self-Assembly-Directed Collagen-Peptide-Decorated Liposomal Complexes of Curcumin Microspheres with Enhanced Solubility and Bioavailability

M¹,

Balakrishnan²,

Joseph³

et al. 2023

ACS Omega

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“…Free drugs releasing from L‐drugs could be regulated by liposome stability optimization. It has been found that liposome encapsulation could reduce toxicity and increase efficacy of drug through manipulating drugs release (mainly slow release) [11]. Simultaneous pharmacokinetic characterization of the free drugs and liposome‐encapsulating drugs in vivo was important for both liposomal drugs development and clinical application.…”

Section: Introductionmentioning

confidence: 99%

Liposomal doxorubicin and free doxorubicin in vivo quantitation method developed on CE‐LIF and its application in pharmacokinetic analysis

2023

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As a novel drug delivery system, liposomes were used to improve pharmacokinetics/pharmacodynamics (PK/PD) characters, minimize toxicity, and enhance drug–target selectivity. However, heterogeneity of drug releasing process and liposome itself challenged traditional pharmaceutical analytical techniques, especially in vivo pharmacokinetic studies. In this study, a novel liposomal doxorubicin (L‐DOX) pharmacokinetic analysis strategy was developed with capillary electrophoresis coupled with laser‐induced fluorescence (CE‐LIF) detector. The background electrolyte (BGE) system was composed of borate and sodium dodecyl sulfate (SDS), which was optimized to successfully achieve simultaneous online separation and quantitative analysis of free DOX and liposome‐encapsulated DOX. The method was applied to the in vivo pharmacokinetic study of L‐DOX in rats. The results showed that the concentration of total DOX (T‐DOX) was gradually decreasing, while the concentration of L‐DOX was relatively stable, with a concentration of 31.6 ± 4.8 µg/mL within 24 h. It was the first time to achieve liposomal drugs in vivo analysis with CE‐LIF. CE‐LIF was proved as potential rapidly real‐time analytical methods for liposomal drugs in vivo occurrence monitoring.

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“…19 Henceforth, PDDA polymer was proven by Othman et al, to be an effective polymer in increasing the stability of curcumin inside DMPC liposomes by decreasing thereby its release. 20 Dopamine is a catecholamine neurotransmitter in nervous, cardiovascular and hormonal systems, plays an important role as an extracellular chemical messenger. 21,22 Many diseases result from disorder in the level of dopamine.…”

Section: Introductionmentioning

confidence: 99%

“… 19 Henceforth, PDDA polymer was proven by Othman et al , to be an effective polymer in increasing the stability of curcumin inside DMPC liposomes by decreasing thereby its release. 20 …”

Section: Introductionmentioning

confidence: 99%

Curcumin-PLGA based nanocapsule for the fluorescence spectroscopic detection of dopamine

2022

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Liposome-based nanocapsules for the controlled release of dietary curcumin: PDDA and silica nanoparticle-coated DMPC liposomes enhance the fluorescence efficiency and anticancer activity of curcumin

Abstract: Nanosystems with various compositions and biological properties are being extensively investigated for drug and gene delivery applications.

Cited by 23 publications

References 50 publications

Two-Stage Supramolecular Self-Assembly-Directed Collagen-Peptide-Decorated Liposomal Complexes of Curcumin Microspheres with Enhanced Solubility and Bioavailability

Two-Stage Supramolecular Self-Assembly-Directed Collagen-Peptide-Decorated Liposomal Complexes of Curcumin Microspheres with Enhanced Solubility and Bioavailability

Liposomal doxorubicin and free doxorubicin in vivo quantitation method developed on CE‐LIF and its application in pharmacokinetic analysis

Curcumin-PLGA based nanocapsule for the fluorescence spectroscopic detection of dopamine

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