Liposome-Based Bioassays

Sforzi, Jacopo; Palagi, L; Aime, Silvio

doi:10.3390/biology9080202

Cited by 20 publications

(11 citation statements)

References 95 publications

(108 reference statements)

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“…This amphiphilic property makes liposomes the choice for delivery of the drugs with different polarities (Large et al 2021 ). In 1961, Bangham and Horne first described liposomes at the Babraham Institute in Cambridge, which opened the prelude to the study of liposomes (Sforzi et al 2020 ). In fact, liposomes are the simplest biological cell mimics, and their main components include lipids and fatty acids, which are also present in cell membranes, so liposomes are considered to have good biocompatibility and biodegradability.…”

Section: Properties Of Nanoparticles and Their Applications In Tumorsmentioning

confidence: 99%

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

et al. 2023

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Lung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy have also been applied in the clinics. However, drug resistance and systemic toxicity still cannot be avoided. Based on the unique properties of nanoparticles, it provides a new idea for lung cancer therapy, especially for targeted immunotherapy. When nanoparticles are used as carriers of drugs with special physical properties, the nanodrug delivery system ensures the accuracy of targeting and the stability of drugs while increasing the permeability and the aggregation of drugs in tumor tissues, showing good anti-tumor effects. This review introduces the properties of various nanoparticles including polymer nanoparticles, liposome nanoparticles, quantum dots, dendrimers, and gold nanoparticles and their applications in tumor tissues. In addition, the specific application of nanoparticle-based drug delivery for lung cancer therapy in preclinical studies and clinical trials is discussed.

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Section: Properties Of Nanoparticles and Their Applications In Tumorsmentioning

confidence: 99%

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

et al. 2023

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“…Different types of assays have employed liposomes for biosensing by simply mixing the liposomes with test samples, such as immunoassays [liposome agglutination, liposome immunoaggregation, liposome immunoblotting, immunochromatographic liposome, and liposome-linked immunosorbent assays, (30,31) ]. Liposomes have also been employed as biosensors to detect various analytes (e.g., toxins, pesticides, enzyme, and viruses) (Table 1).…”

Section: Liposomes As Biosensorsmentioning

confidence: 99%

Liposome-based Biosensors and Diagnosis Imaging Agents

Hamano¹,

Negishi²

2022

Sensors and Materials

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The development of biosensors and contrast imaging agents is urgently required to detect and diagnose diseases. Liposomes have been used in various fields as biosensors and imaging agents owing to their biocompatibility, ability to modify the liposomal surface, and encapsulation efficacy for various biologically active agents. In this review, we summarize the current developments and applications of liposome-based biosensors and diagnostic agents, including computed tomography, ultrasound imaging, magnetic resonance imaging, and positron emission tomography. We also discuss future perspectives and challenges associated with the development of liposomal biosensors and imaging agents.

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“…[ 38 ] The fluorescent molecules as a reporter probe can be connected with liposomes to amplify signals. [ 39 ] The commonly used fluorescent dyes are sulforhodamine and carboxyfluorescein. [ 40 ] This method usually uses one DNA strand anchored on magnetic beads as a anchor chain, and the other DNA strand was attached on the liposome as a reporter strand ( Figure a).…”

Section: Applicationsmentioning

confidence: 99%

Nucleic Acid‐Modified Liposome: Construction Methods and Biological Applications

Liang

Zhu

et al. 2021

Adv Materials Inter

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Liposomes with excellent biocompatibility have been widely used in nutraceutical and biomedical fields for delivery of bioactive molecules. Functional nucleic acids including aptamers that have good target recognizing ability and molecular assembly properties can be used to modify liposomes to expand their applications. This review comprehensively summarizes and comparatively discusses the construction strategies including covalent methods, noncovalent methods, and protein‐mediated methods for fabricating nucleic acid‐modified liposomes. Their applications in stability enhancement, biosensing, drug delivery, and synthesis of biomimetic structures are then reviewed. From above, it is concluded that the nucleic acid‐modified liposome, as a newly developed advanced material, has a good potential to be applied for biosensor or pharmaceutical purposes.

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Liposome-Based Bioassays

Cited by 20 publications

References 95 publications

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Liposome-based Biosensors and Diagnosis Imaging Agents

Nucleic Acid‐Modified Liposome: Construction Methods and Biological Applications

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