Liposome Associated Interferon-Alpha 2B Functions as an Anti-Fibrogenic Factor in Guinea Pig Dermal Wound

Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia

“…MF even completely disappeared when combining high-dose interferon-a with low-dose cytosine arabinoside. Therefore, an antifibrotic in vivo effect of interferon-a could be ascertained supporting results from animal models and earlier in vitro evaluations [28][29][30] and confirming a recent comparison of interferon-a with chemotherapy on a random basis. 10 The favorable response of MF to the combination of high-dose interferon-a with low-dose cytosine arabinoside, furthermore, is in agreement with superior cytogenetic response rates and prolonged survival of patients observed in two randomized studies comparing this combination with interferon-a monotherapy.…”

“…Inhibitory effects on fibroblasts as well as on cells inducing fibroblasts to produce fibers -such as megakaryocytes -may be other reasons, as indicated by in vitro examinations. 29,30,40 The prognostic significance of MF was furthermore independent of two other important prognostic factors, the risk score before onset of therapy and the hematologic remission during treatment. Interestingly, in both patient groups, the New CML Score provided independent prognostic information only with respect to overall survival times of patients whereas the hematologic respose was more relevant to the survival times in chronic phase.…”

“…Indeed, an antifibrotic effect of interferon-a on fibrosis has recently been reported on the basis of BMBs taken prospectively during the course of disease, 10 thus supporting the results from animal models and in vitro studies showing inhibition of procollagen production and fibroblast growth by this cytokine. [28][29][30] However, the possible influences of the interferon dosage and of a combination with cytosine arabinoside have not yet been considered although they may influence the probability of cytogenetic remission. [31][32][33][34] Therefore, BMBs from 200 patients recruited in two prospective therapeutic studies on CML, 16,32,35,36 using different doses of interferon-a with or without cytosine arabinoside, were analyzed with respect to the presence and the evolution of MF.…”

Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

“…Biomaterials may be used to modify wound healing, either as matrices to support and promote tissue organization, or as barriers to limit scar tissue formation. Another utilization for biomaterials is as a carrier for bioactive substances, such as cytokines, growth factors, or living cells 1–4. Examples of carriers that have been used in the past include polymers,2 collagen,1 and liposomes 3.…”

miRNA Control of Tissue Repair and Regeneration

“…These ECM-derived scaffolds, in addition to serving as physical support to promote tissue organization, resist aggressive wound contraction 108 and scar tissue formation. 109 These scaffolds also serve as vehicles to deliver bioactive substances such as cytokines, 110 growth factors, 109 living cells, 111 and vectors for gene therapy. Primary fibroblasts cultured on miR-29be loaded scaffolds resulted in attenuated levels of collagen type I and III gene expression.…”