Liposomal Phenylephrine Nanoparticles Enhance the Antitumor Activity of Intratumoral Chemotherapy in a Preclinical Model of Melanoma
Emmanuel M. Gabriel,
Deborah Bahr,
Hari Krishnareddy Rachamala
et al.
Abstract:Intratumoral
injection of anticancer agents has limited
efficacy
and is not routinely used for most cancers. In this study, we aimed
to improve the efficacy of intratumoral chemotherapy using a novel
approach comprising peri-tumoral injection of sustained-release liposomal
nanoparticles containing phenylephrine, which is a potent vasoconstrictor.
Using a preclinical model of melanoma, we have previously shown that
systemically administered (intravenous) phenylephrine could transiently
shunt blood flow to the t… Show more
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