Liposomal nanohybrid cerasomes for controlled insulin release

Jin, Yushen; Li, Yanyan; Pan, Hongjie; Dai, Zhifei

doi:10.1039/c4ra08515a

Cited by 16 publications

(13 citation statements)

References 38 publications

(46 reference statements)

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“…As an emerging platform, partially silica-coated organic-inorganic nanohybrid (cerasomes) exhibit integrated properties of traditional lipid-based NPs and inorganic silica NPs. Cerasomes are biomimetic colloidal NPs with an additional layer of the polyorganosilxane network which imparts cerasomes with higher stability than conventional liposomes (Jin et al, 2014 ). Nano-sized cerasomal NPs have various advantages, including biocompatibility, prolonged blood circulation, higher tumor accumulation by enhanced permeability and retention (EPR) effect, and decreased reticuloendothelial system (RES) clearance (Jin et al, 2014 ).…”

Section: Nanocarriers: Recent Advances and Challengesmentioning

confidence: 99%

“…Cerasomes are biomimetic colloidal NPs with an additional layer of the polyorganosilxane network which imparts cerasomes with higher stability than conventional liposomes (Jin et al, 2014 ). Nano-sized cerasomal NPs have various advantages, including biocompatibility, prolonged blood circulation, higher tumor accumulation by enhanced permeability and retention (EPR) effect, and decreased reticuloendothelial system (RES) clearance (Jin et al, 2014 ). Thus, cerasomal NPs are capable of overcoming pharmacological limitations with substantial advantages over conventional nanocarriers (Yue and Dai, 2014 ).…”

Section: Nanocarriers: Recent Advances and Challengesmentioning

confidence: 99%

“…The unique physiological and biological properties of cerasomes have accredited them as a fascinating platform for cancer theranostics (Jin et al, 2014 ; Ding et al, 2015 ; Fu et al, 2015 ). The sol-gel processed cerasomes with precise nanostructure are inevitable choice in cancer therapy mainly due to: (a) the possibility to incorporate various hydrophilic/ hydrophobic payloads with higher encapsulation efficiency and loading capacity, (b) the ease of tuning their internal chemistry (composition) and surface properties can allow further conjugation of imaging moieties, and (c) the excellent cellular and tissue biocompatibility of cerasomes can attenuate the toxic effect related to the silica NPs.…”

Section: The Emergence Of Partially-silica Coated Hybrid Nanocarriersmentioning

confidence: 99%

“…Among these nanohybrid platforms, liposomes like partially silica coated bilayered nanohybrids (∂SiNHs), namely cerasomes and bicelles, have witnessed a considerable rise in the broad spectrum biological applications such as drug delivery, diagnosis, and treatment of cancer and related diseases (Yasuhara et al, 2012 ; Jin et al, 2014 ). Such ∂SiNHs nanohybrids are of immense interest owing to the advantages such as low toxicity, controllable size and shape, biocompatible, and good stability in a physiological condition (Jin et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics

2018

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Over years, theranostic nanoplatforms have provided a new avenue for the diagnosis and treatment of various cancer types. To this end, a myriad of nanocarriers such as polymeric micelles, liposomes, and inorganic nanoparticles (NPs) with distinct physiochemical and biological properties are routinely investigated for preclinical and clinical studies. So far, liposomes have received great attention for various biomedical applications, however, it still suffers from insufficient morphological stability. On the other hand, inorganic NPs depicting excellent therapeutic ability have failed to address biocompatibility issues. This has raised a serious concern about the clinical approval of multifunctional organic or inorganic-based theranostic agents. Recently, partially silica coated nanohybrids such as cerasomes and bicelles demonstrating both diagnostic and therapeutic ability in a single system, have drawn profound attention as a fascinating novel drug delivery system. Compared with traditional liposomal or inorganic-based nanoformulations, this new and highly stable nanocarriers integrates the functional attributes of biomimetic liposomes and silica NPs, therefore, synergize strengths and functions, or even surpass weaknesses of individual components. This review at its best enlightens the emerging concept of such partially silica coated nanohybrids, fabrication strategies, and theranostic opportunities to combat cancer and related diseases.

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Section: Nanocarriers: Recent Advances and Challengesmentioning

confidence: 99%

Section: Nanocarriers: Recent Advances and Challengesmentioning

confidence: 99%

Section: The Emergence Of Partially-silica Coated Hybrid Nanocarriersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics

2018

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“…Additionally, composite cerasomes could optimize the release profile of HCPT by the alteration in vesicle compositions, leading to a significantly improved pharmacokinetic profile in vivo. Similarly, Jin et al [43] reported the fabrication of composite cerasomes for controlled insulin release by altering vesicle composition through incorporating the phospholipid of DPPC into cerasomes. More importantly, the insulin-loaded composite cerasomes showed a significant and prolonged hypoglycaemic effect compared with liposomes and free insulin.…”

Section: Applications Of Cerasomes As Drug Nanocarriersmentioning

confidence: 99%

 Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers

Li¹,

Jiang²,

Zhu³

et al. 2017

Gen. Chem.

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Despite many benefits, liposomes have still not realized their full potential as vehicles for drug delivery due to the morphological instability. Recently, liposomal nanohybrid cerasomes have been developed as novel drug nanocarriers based on organoalkoxysilane through a sol-gel reaction in combination with self-assembly process. The presence of polyorganosiloxane network on the surface imparts cerasomes higher morphological stability than conventional liposomes and the incorporation of liposomal bilayer structure into cerasomes boosts the biocompatibility in comparision with silica nanoparticles with similar size. Moreover, cerasomes are able to encapsulate various drug molecules and exhibit controlled drug release profile. In addition, cerasomes are easy to be conjugated with biomolecules through silane-coupler chemistry due to the silanols on the surface. Therefore, cerasomes are expected to be ideal drug delivery systems owning to the unique advantages. The present paper will briefly introduce the preparation and properties of cerasomes, followed by reviewing the progress of cerasomes for drug delivery.

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Reality Check for Nanomaterial‐Mediated Therapy with 3D Biomimetic Culture Systems

Tay

Muthu

Chia

et al. 2016

Adv Funct Materials

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The recent progresses in tissue engineering and nanomaterial‐based therapeutics/theranostics have led to the ever increasing utilization of 3D in vitro experimental models as the bona fide culture systems to evaluate the therapeutic/theranostic effects of nanomedicine. Compared to the use of conventional 2D culture platforms, 3D biomimetic cultures offer unmatched advantages as relevant physiological and pathological elements can be incorporated to allow better characterization of the engineered bio‐nanomaterials in the targeted tissue‐specific microenvironment. In this Feature Article, the current state‐of‐the‐art 3D in vitro models that have been developed for the evaluation of biosafety and efficacy of nano‐ therapeutics/theranostics targeting the colon, blood–brain barrier (BBB), lungs, skin tumor models to bridge the nanomedicine bench to pre‐clinical ravine are reviewed. Furthermore, the critical physicochemical parameters of the bio‐nanomaterials that govern its transport and biodistribution in a complex 3D microenvironment will be highlighted. The major challenges and future prospects of evaluating nanomedicine in the third dimension will also be discussed.

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Liposomal nanohybrid cerasomes for controlled insulin release

Abstract: This study reported a facile fabrication of a reproducible and injectable cerasomal insulin formulation by encapsulating insulin into cerasomes via one-step construction.

Cited by 16 publications

References 38 publications

Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics

Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics

Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers

Reality Check for Nanomaterial‐Mediated Therapy with 3D Biomimetic Culture Systems

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Liposomal nanohybrid cerasomes for controlled insulin release

Abstract: This study reported a facile fabrication of a reproducible and injectable cerasomal insulin formulation by encapsulating insulin into cerasomes via one-step construction.

Cited by 16 publications

References 38 publications

Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics

Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics

&nbsp;Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers

Reality Check for Nanomaterial‐Mediated Therapy with 3D Biomimetic Culture Systems

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Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers