Abstract:Piperlongumine (PL) is an alkaloid isolated from the Piper species, which can induce apoptosis in cancer cells but has little inhibitory effect on the growth of normal cells. However, its poor aqueous solubility has largely limited its therapeutic applications. To address this issue, we developed liposomal nanoformulations for PL (nanoPLs) in this study. The optimized nanoPLs exhibited a small average diameter in the range of 100-160 nm and narrow size distribution as well as high encapsulation efficiency. Nan… Show more
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