Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer

Abstract

The present findings suggest that Lipo-HNK may provide an effective approach to inhibit tumor growth in both cisplatin sensitive and -resistant human ovarian cancer with minimal side effects.

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

“…Recently, magnolol and honokiol have been reported to have antitumor action by inhibiting proliferation, inducing apoptosis and differentiation, countering metastasis, suppressing angiogenesis, and reversing multidrug resistance (10,28,29). Numerous signaling pathways have been implicated in the regulation of apoptosis by magnolol and honokiol (30).…”

Self-Assembled Hydrophobic Honokiol Loaded MPEG-PCL Diblock Copolymer Micelles

“…Previous reports demonstrated that honokiol could treat cancers by causing cell cycle arrest (6,7), inhibiting angiogenesis (8), and inducing apoptosis (9)(10)(11)(12). Meanwhile, honokiol could overcome conventional drug resistance (13)(14)(15) and also showed synergistic antitumor effect with other anticancer agents such as cisplatin or adriamycin (16,17). When many studies around the pharmacodynamics and pharmacology of honokiol attract great attention, questions around the formulation of honokiol should also be attended due to the fact that honokiol is water insoluble.…”

Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells

“…In brief, the cells (1 × 10 4 in 100 μL) were seeded on 96-well plates in triplicate. Following a culture at 37 for 24 ℃ h, the medium was replaced with fresh medium at various concentrations of HNK (10,15 Co., USA) [14].…”

“…Following a 24h-culture at 37 , the media were repla ℃ -ced with fresh medium at various concentrations of HNK (10,15 [15].…”

“…To detect DNA fragments, OSCC cells were exposed to 15 ) and ethanol (99.5%), dissolved in a loading buffer (Takara, Japan), and illustrated the DNA fragmentation under ultraviolet light (Bio-Rad, American) [17] after the electrophoresis on 2% agarose gels (Gene-Tech Co., Shanghai, China).…”