Liposomal formulation of new arsenic schiff base complex as drug delivery agent in the treatment of acute promyelocytic leukemia and quantum chemical and docking calculations

Iraji, Mahsa; Salehi, Mehdi; Malekshah, Rahime Eshaghi; Khaleghian, Ali; Shamsi, Fahimeh

doi:10.1016/j.jddst.2022.103600

Cited by 14 publications

(11 citation statements)

References 63 publications

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“…By inhibiting the Bcl-2 protein located on the mitochondrial membrane, it causes the release of cytochrome C. As a result, caspases 3 and 9 are activated, and thus, they regulate apoptosis. 99,100 Molecular docking studies were performed to explain the binding affinity, the binding orientation, or conformation of a synthesized compound in the protein's active site. According to Fig.…”

Section: Computational Details and Resultsmentioning

confidence: 99%

Phytic acid-modified graphene/cobalt oxide nanocomposites: synthesis, characterization, theoretical studies, antiproliferative properties, and catalytic activities

et al. 2023

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Section: Computational Details and Resultsmentioning

confidence: 99%

Phytic acid-modified graphene/cobalt oxide nanocomposites: synthesis, characterization, theoretical studies, antiproliferative properties, and catalytic activities

et al. 2023

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“…Compared with inorganic nanomaterials, such as nano-gold, nano-silicon, and nano-carbon, polymer materials have better biosafety, which indicates their greater application potential in drug delivery and clinical practice [ 38 , 40 , 66 ]. PLGA is recognized as one of the most biodegradable polymer materials currently synthesized, with good controllability, biodegradability, and biocompatibility [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the emergence of functional nanomaterials has provided new ideas for improving the detection sensitivity and specificity of imaging agents [ 38 – 40 ]. Nanoimaging agents can utilize enhanced permeability and retention effects (EPR) to promote the accumulation of imaging agents, reduce nonspecific distribution, and improve imaging specificity [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

et al. 2023

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Background TMVP1 is a novel tumor targeting polypeptide screened by our laboratory with a core sequence of five amino acids LARGR. It specially binds to vascular endothelial growth factor receptor-3 (VEGFR-3), which is mainly expressed on neo-lymphatic vessels in sentinel lymph node (SLN) with tumor metastasis in adults. Here, we prepared a targeted nanoprobe using TMVP1-modified nanomaterials for tumor metastasis SLN imaging. Results In this study, TMVP1-modified polymer nanomaterials were loaded with the near-infrared (NIR) fluorescent dye, indocyanine green (ICG), to prepare a molecular imaging TMVP1-ICG nanoparticles (NPs) to identify tumor metastasis in SLN at molecular level. TMVP1-ICG-NPs were successfully prepared using the nano-precipitation method. The particle diameter, morphology, drug encapsulation efficiency, UV absorption spectrum, cytotoxicity, safety, and pharmacokinetic properties were determined. The TMVP1-ICG-NPs had a diameter of approximately 130 nm and an ICG loading rate of 70%. In vitro cell experiments and in vivo mouse experiments confirmed that TMVP1-ICG-NPs have good targeting ability to tumors in situ and to SLN with tumor metastasis by binding to VEGFR-3. Effective photothermal therapy (PTT) with TMVP1-ICG-NPs was confirmed in vitro and in vivo. As expected, TMVP1-ICG-NPs improved ICG blood stability, targeted tumor metastasis to SLN, and enhanced PTT/photodynamic (PDT) therapy, without obvious cytotoxicity, making it a promising theranostic nanomedicine. Conclusion TMVP1-ICG-NPs identified SLN with tumor metastasis and were used to perform imaging-guided PTT, which makes it a promising strategy for providing real-time NIR fluorescence imaging and intraoperative PTT for patients with SLN metastasis.

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“…Schiff bases show biological activities like nematicidal [20], insecticidal [21], antibacterial [22], antifungal [23], antileukaemia [24], anti-inflammatory [25], anti-HIV activity [26], antimycobacterial activity [27], antioxidant [28], anticancer [29], and plant growth regulatory activity [30] among others. Besides biological applications, Schiff base and their metal complexes have enormous applications in analytical chemistry [31], dye industry [32], and corrosion inhibitors [33].…”

Section: Introductionmentioning

confidence: 99%

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

Meena¹,

Meena²,

Kumari³

et al. 2023

Schiff Base in Organic, Inorganic and Physical Chemistry

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The development of Schiff base was a major step forward in the area of coordination chemistry. Schiff bases, a class of organic compounds, carry the imine or azomethine (>C=N–) functional group. Schiff bases played an influencing role in the development of coordination chemistry and were a key point in the development of inorganic, bioinorganic chemistry and optical materials. Schiff bases, widely used in inorganic, organic, and analytical chemistry, account for a significant portion of the more commonly employed classes of organic molecules. The ability of Schiff base ligands to form stable metal complexes with a wide range of transition and other metal ions makes them extremely useful. Condensation of a primary amine with an aldehyde or ketone yields a Schiff bases. In this chapter, we focused on introducing Schiff bases, classified them and their metal complexes, and discussed several synthesis methods, including conventional and green approaches. This chapter also elaborated on the industries’ applications, such as the food industry, agrochemical industry, dye industry, analytical chemistry, catalysis, energy storage, environmental, chemo-sensing, bio-sensing, and biomedical applications of novel Schiff bases and their metal complexes.

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Liposomal formulation of new arsenic schiff base complex as drug delivery agent in the treatment of acute promyelocytic leukemia and quantum chemical and docking calculations

Cited by 14 publications

References 63 publications

Phytic acid-modified graphene/cobalt oxide nanocomposites: synthesis, characterization, theoretical studies, antiproliferative properties, and catalytic activities

Phytic acid-modified graphene/cobalt oxide nanocomposites: synthesis, characterization, theoretical studies, antiproliferative properties, and catalytic activities

A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

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