Liposomal Encapsulated Rhodomyrtone: A Novel Antiacne Drug

Chorachoo, Julalak; Amnuaikit, Thanaporn; Voravuthikunchai, Supayang Piyawan

doi:10.1155/2013/157635

Cited by 34 publications

(24 citation statements)

References 27 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liposomal encapsulated rhodomyrtone was prepared by the ethanol injection method as previously described [ 18 ]. The lipid phase was made from a mixture of soybean phosphatidylcholine (Sigma, St. Louis, MO, USA) and cholesterol from lanolin (Fluka, Tokyo, Japan) at a ratio of 4:1 in 10 mL of absolute ethanol.…”

Section: Methodsmentioning

confidence: 99%

Effects of Rhodomyrtus tomentosa Leaf Extract on Staphylococcal Adhesion and Invasion in Bovine Udder Epidermal Tissue Model

et al. 2015

View full text Add to dashboard Cite

Bovine mastitis is one of the most important infectious diseases in dairy herds, and staphylococci are the most important etiologic agents of this disease. Antibiotics and chemical agents used in livestock for prevention and cure of the disease can accumulate in milk and give rise to food safety concerns. Rhodomyrtus tomentosa leaf extract was studied as an alternative approach to reduce the bacterial infections. The ethanolic extract of this plant demonstrated antibacterial activity with minimum inhibitory concentration (MIC) values as low as 16–64 μg/mL against staphylococcal isolates. In addition, the extract had an effect on the bacterial cell surface properties by increasing its hydrophobicity in a concentration dependent manner. To further extend the antibacterial efficacy, silver nanoparticles synthesized with the extract, a pure rhodomyrtone, and liposomal encapsulated rhodomyrtone were applied and their inhibitory effects on bacterial adhesion and invasion were determined by ex vivo study in a bovine udder epidermal tissue model. These agents exerted remarkable antibacterial activity against staphylococci and decreased the adhesion of the bacterial cells to the tissues. These results supported that R. tomentosa ethanolic extract could be applied as an alternative agent for bovine udder care in dairy farms.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of Rhodomyrtus tomentosa Leaf Extract on Staphylococcal Adhesion and Invasion in Bovine Udder Epidermal Tissue Model

et al. 2015

View full text Add to dashboard Cite

show abstract

“…These results are consistent with previous reports revealing that increasing the total lipid concentration favors the formation of large unilamellar vesicles/multilamellar vesicles (MLV), and thereby, increases the trapped volume for the encapsulated drug within liposomes. 37,38) Influence of Drug Concentration on the Encapsulation Efficiency of PMX Increasing PMX concentration from 5 to 25 mg/mL was found to increase the percentage of PMX loading, however, the entrapment efficiency of PMX tended to decrease for all formulations ( Table 5). The highest entrapment efficiencies of PMX were obtained for PMX at a dose of 5 mg/mL.…”

Section: Effect Of Phospholipid Type and The Presence Of Cholesterol mentioning

confidence: 99%

Liposomal Pemetrexed: Formulation, Characterization and <i>in Vitro</i> Cytotoxicity Studies for Effective Management of Malignant Pleural Mesothelioma

Eldin

El-Nahas

Mahdy

et al. 2015

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Pemetrexed (PMX) is a newly developed multi-targeted anti-folate with promising clinical activity in many solid tumors including malignant pleural mesothelioma (MPM). However, PMX does not show sufficient anti-tumor activity in vivo when used alone either due to inefficient delivery of adequate concentrations to tumor tissue or dose-limiting side effects. In order to overcome these problems and to achieve potent anti-tumor activity, PMX was encapsulated into a liposomal delivery system. In the present study, various formulations of liposomal PMX were prepared. The effect of formulation parameters on the encapsulation efficiency of PMX within liposomes was evaluated. In addition, the influence of drug release rate on the in vitro cytotoxicity was investigated. Encapsulation of PMX within liposomes was remarkably increased by the incorporation of cholesterol within liposomal membranes and by increasing the total lipid concentration. Encapsulation efficiency was found to be unaffected by the type of phospholipid used or the inclusion of a cation lipid, DC-6-14. Interestingly, encapsulation of PMX within "fluid" liposomes was found to allow efficient release of PMX from liposomes resulting in a potent in vitro cytotoxicity against MPM MSTO-211H cell line. On the other hand, entrapment of PMX within "solid" liposomes substantially hindered PMX release from liposomes, and thus PMX failed to exert any in vitro cytotoxicity. These results suggest that encapsulation of PMX within "fluid" liposomes might represent a novel strategy to enhance the therapeutic efficacy of PMX while minimizing the side effect encountered by the non selective delivery of free PMX to various body tissues.Key words liposome; malignant pleural mesothelioma; polyethylene glycol; pemetrexed Pemetrexed (PMX) is a new-generation anti-folate, approved for the treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer, currently being evaluated for the treatment of a variety of other solid tumors.

show abstract

“… They are spherical vesicles composed of lipid bilayer which is used as a carrier or a vehicle for the delivery of drugs into a particular site and thus, improving the therapeutic effect of liposomal drugs. In liposomes, both hydrophilic and hydro-phobic drugs can be incorporated 21 .…”

Section: Topical Antibioticsmentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

Acne is a common inflammatory disorder which is common among the adolescent age groups. Even though it is not a life-threatening disease but it affects the patient's self-esteem. Additionally, they have also gone into depression and suicidal ideation. Based on the severity it can be classified into several types. Various factors are responsible for the occurrence of acne. The main factors are discussed in this article. According to the Global Burden of Disease study about 85% of the populations are being affected when we consider the epidemiology. Among this, the Americans are most prone to it. A variety of medications are available in the market for the treatment of acne like retinoid derivatives, benzoyl peroxide, and antibiotics etc. Among which the topical treatment is most preferred. Other treatments are carried out only if the existing treatment doesn't give the desired results. Nanotechnology has also been incorporated for the existing drug in order to target the disease. Acne can be induced in the animal. Existing works of literature gives information on how to induce acne in an animal by using bacteria as well as chemical. Different in-vitro and in-vivo studies exist to determine several aspects of the drug. In this article, we have focused on all the above topics in brief. INTRODUCTION: Acne is otherwise called as acne vulgaris. It is a chronic inflammatory disease. It occurs on the parts like: face, neck, upper chest, upper back, etc. According to studies, acne is the most prevalent disease in the world. It affects the patient both psychologically as well as psychosocially. The available topical treatments are having few side effects.

show abstract

Liposomal Encapsulated Rhodomyrtone: A Novel Antiacne Drug

Cited by 34 publications

References 27 publications

Effects of Rhodomyrtus tomentosa Leaf Extract on Staphylococcal Adhesion and Invasion in Bovine Udder Epidermal Tissue Model

Effects of Rhodomyrtus tomentosa Leaf Extract on Staphylococcal Adhesion and Invasion in Bovine Udder Epidermal Tissue Model

Liposomal Pemetrexed: Formulation, Characterization and <i>in Vitro</i> Cytotoxicity Studies for Effective Management of Malignant Pleural Mesothelioma

Untitled

Contact Info

Product

Resources

About