Liposomal Drug Delivery for Postoperative Pain Management

Viscusi, Eugene R.

doi:10.1016/j.rapm.2005.05.001

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…The advantages of encapsulating LA in liposomes are the slow drug release, prolonged anesthetic effect and reduced toxicity towards the cardiovascular and central nervous systems [6,15,16,21,22].…”

Section: Liposome-based La Formulationsmentioning

confidence: 99%

Drug Delivery Systems for Local Anesthetics

Paula¹,

Cereda²,

Tófoli³

et al. 2010

DDF

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Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aims to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug-delivery of topical and injectable local anesthetics, as described in recent patents.

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Section: Liposome-based La Formulationsmentioning

confidence: 99%

Drug Delivery Systems for Local Anesthetics

Paula¹,

Cereda²,

Tófoli³

et al. 2010

DDF

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“…After administering the drug into the epidural space, morphine is released from the liposomal vesicles over a period of time [1]. This delivery system potentially leads to extended pain control [6,9,16] and contributes to reduced systemic drug exposure and toxicity [6,9,16].…”

Section: Introductionmentioning

confidence: 99%

Lessons Learned with Extended-release Epidural Morphine after Total Hip Arthroplasty

Kahl

Parvızı

Viscusi

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…1 As such, liposomal formulations can be used as vehicles to deliver medication to specific targets while avoiding high plasma levels and/or systemic toxicity. 1,2 DepoFoam is a drug delivery system that prolongs drug release by encapsulating the drug in multivesicular liposomes made up of nonconcentric multiple lipid layers. [3][4][5][6] The lipid layers in DepoFoam are composed of biodegradable phospholipids, cholesterol, and triglycerides.…”

mentioning

confidence: 99%