Liposoluble vitamin encapsulation in shell–core microparticles produced by ultrasonic atomization and microwave stabilization

Barba, Anna Angela; Dalmoro, Annalisa; D’Amore, Matteo; Lamberti, Gaetano

doi:10.1016/j.lwt.2015.05.040

Cited by 19 publications

(8 citation statements)

References 19 publications

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“…Vitamin D, and in particular the D3 form or cholecalciferol, is able to adjust the in vivo metabolization of calcium and phosphorus against osteoporosis, and its deciency provokes an increased risk of many diseases, such as osteoporosis, some cancers, type 1 diabetes, cardiovascular diseases. 21 Vitamin K is required by body for both synthesizing some proteins which are prerequisites for blood coagulation and controlling binding of calcium in bones and other tissues, thus a poor vitamin K status is associated with an increased risk of osteoporotic bone fractures. 22 The most widely used vitamin K form for supplementation is vitamin K2 and more specically menaquinone-4, more used in trials with bone outcomes, and menaquinone-7, more used in trials with cardiovascular outcomes.…”

Section: Introductionmentioning

confidence: 99%

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Dalmoro

Bochicchio²,

Lamberti

et al. 2019

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Dalmoro

Bochicchio²,

Lamberti

et al. 2019

RSC Adv.

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“…As reported in previous works the encapsulation efficiency was subjected to several factors, mainly drug molecular weight and solubility and polymeric network mesh‐size (PNMS), which play a crucial role on drug losses due to diffusive transport phenomena occurring during reticulation stage of microparticles production. Adding a polymeric mesh‐size reducer ingredient (such as the Pluronic) has demonstrated that better encapsulation efficiency can be allowed but this strategy, in general, must be evaluated on the bases of drug an polymer features.…”

Section: Resultsmentioning

confidence: 99%

Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell–core microparticles

Dalmoro

Sitenkov

Lamberti

et al. 2015

J of Applied Polymer Sci

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In this study ultrasound-assisted atomization technique was combined with two-stages polyelectrolyte complexation to produce enteric shell-core microparticles encapsulating a non-steroidal, anti-inflammatory gastrolesive active ingredient indomethacin. In particular, a solution of the anionic biopolymer alginate, containing indomethacin, was sprayed in fine droplets which were complexed with a cationic (meth)acrylate copolymer, Eudragit V R E 100, which, in turn, was complexed by the anionic copolymer Eudragit V R L30D-55. The first complexation stage was applied to achieve a high drug encapsulation efficiency; the second one to assure good gastroresistance feature. The novel protocol has been found more effective in terms of loading, encapsulation efficiency, and enteric properties during in vitro release tests, than conventional procedures which involved alginate cross-linking by charged ions. Furthermore ultrasonic atomization-polyelectrolytes complexation preparation approach was performed using mild conditions, aqueous solutions, in the absence of organic solvents and chemical cross-linkers.

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“…Finally, as presented in Table 1, many other attempts were also carried out to improve water solubility, stability, and bioavailability of VD using different encapsulation strategies, like protein-based delivery systems [32,39,41], solid lipid [42] and nanostructured lipid carriers [43,44], liposomes [46], and microparticle [47]. Interestingly, most researchers underline the fact that VD is a vitamin sensitive to external factors.…”

Section: Drug Delivery Systems For Oral Administration (Food Fortimentioning

confidence: 99%

Drug Delivery Systems for Vitamin D Supplementation and Therapy

2019

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Vitamin D (VD) is a fat-soluble prohormone well known for its role in regulating calcium and phosphate metabolism. It has been clinically used for many years to prevent rickets in children, osteomalacia, and osteoporosis in adults. VD insufficiency is a common medical condition, and many supplements are available in the market in order to increase serum 25-hydroxy VD levels to recommended amounts. Over the course of the last decades, it has become increasingly clear that calcitriol, an active form of VD, regulates multiple cellular processes with effects on normal and malignant cell growth and differentiation, and on the immune and cardiovascular function. Increasing evidence supports the role of the VD system in cancer prevention and therapy. Due to many pleiotropic and beneficial effects in extra-skeletal disorders, VD has gained potential and become an interesting active for encapsulation into drug delivery systems. The purpose of this review is to present the diversity of drug delivery systems that have been reported for VD or VD derivatives in an orderly manner across the following categories: Oral administration, application on the skin, cancer prevention/therapy, and other diseases or routes of administration.

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Liposoluble vitamin encapsulation in shell–core microparticles produced by ultrasonic atomization and microwave stabilization

Cited by 19 publications

References 19 publications

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell–core microparticles

Drug Delivery Systems for Vitamin D Supplementation and Therapy

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