Liposclerosing Myxofibrous Tumor in a Patient with Prostate Cancer

Abstract

Case: A 64-year-old man diagnosed with prostate cancer was incidentally found to have a lesion in his distal femur. Although initially concerning for metastatic prostate cancer, after biopsy by an orthopaedic oncology specialist, a diagnosis of liposclerosing myxofibrous tumor (LSMFT) was confirmed. The lesion was treated with curettage and demineralized bone matrix grafting with close follow-up. Conclusions: This case report illustrates that LSMFT is not confined to the proximal femur and highlights the differences in radiographic appearance between LSMFT and more common metastatic bone lesions.

Lipoesclerosing Myxofibrous Tumor: When The Site It Is Important

“…The histological appearance consists of lobules of mature fat with delicate trabeculae of woven and pre-existing lamellar bone. This lesion may demonstrate fat necrosis, histiocytes and fibrosis but lacks the characteristic constellation of features seen in LSMFT [12,16]. Fat necrosis can be seen in higher-stage lesions of intraosseous lipoma.…”

“…FD, this is a benign fibroosseous proliferation that replace the normal bone marrow. This is more frequent in childhood and commonly occurs in the proximal femur [16]. The histological findings show a homogeneous pattern characterized by curved, Chinese character-like bony trabeculae without osteoblastic rim.…”