Liposarcomas are rare tumors representing 1% of malignant tumors. These are high grade malignant mesenchymal tumors related to adipocyte tissue differentiation. Pleomorphic forms are very aggressive with a high likelihood of systemic spread and poor prognosis. Through two cases of chest pleomorphic liposarcoma, our goal is to look on the prognostic variability of the same pathological entity depending on its location.