Liposarcomas: Prognosis and management

Abstract

Fifty-one evaluable patients with liposarcomas were reviewed. Two-thirds of the patients were referred after local recurrence. One-third with primary surgery at RPMI had local recurrence rate of 31.6%. Overall, one or more local recurrences presented in 78% of patients. Pulmonary metastases, occurred in 45%, while liver metastases in 13.6%. Most common primary sites were the lower extremity, followed by the retroperitoneal area and upper extremity. Median survival is better for upper and lower extremities than other areas (P less than 0.01). The medium survival was longer in the group that received radiation after resection although the difference was not statistically significant. The high rate of local recurrences suggests the adjuvant use of radiation postoperatively when the surgical margins have not been adequate. Sixteen patients are alive and disease-free, with 10 of them having had five years or longer follow-up.

Management of giant intermuscular lipoma of hips: A case report and review of literature

“…Intermuscular lipomas should also be distinguished from liposarcomas in terms of malignancy. The possibility of liposarcoma should be considered when a fatty tumor with a dimension of >10 cm has shown rapid growth (11). Imaging examinations may be of crucial importance in the differentiation between the two tumors.…”

“…Intramuscular lipomas, however, arise between muscle fibers, pass through the intermuscular septa and infiltrate the surrounding tissues, rendering removal of the lesion from the nearby muscles difficult (8)(9)(10). Liposarcomas are malignant soft tissue tumors reported in radiological as well as histological findings to comprise 7-27% of the soft tissue sarcomas (11), and be able to mimic inter-and intramuscular lipomas, rendering the diagnosis and choice of treatment difficult (12).…”

Giant lipomas of the upper extremity

“…Well-differentiated liposarcomas, as seen in patient 5, account for approximately 40% to 45% of liposarcomas (1). Recent rapid growth, size larger than 5 cm and intramuscular location have all been reported to be risk factors for malignancy (1,5,6).…”

Giant Mixed Lipoma/Liposarcoma of the Thigh: Diagnostic Approaches and Surgical Management

“…There are also reports that the intramuscular location of a lipoma is a risk factor for malignancy [2,3]. The lower extremities are one of the most common sites for liposarcomas [8,9]. In this site, when diagnosis of liposarcoma is sure, Campbell et al recommends wide excision or amputation if needed [10].…”

“…They have reported a high probability of recurrence (91%) secondary to conservative initial treatment. Some authors have reported that postoperative adjuvant radioterapy lengthens the median survival rate when surgical excision has not been adequate [7,8,10].…”