Liposarcoma: Clinico-pathological analysis, prognostic factors and survival in a series of 307 patients treated at a single institution

Muratori, Francesco; Frenos, Filippo; Bettini, Lidia; Matera, Davide; Mondanelli, Nicola; Scorianz, Maurizio; Cuomo, Pierluigi; Scoccianti, Guido; Beltrami, Giovanni; Greto, Daniela; Livi, Lorenzo; Baldi, Giacomo Giulio; Roselli, Giuliana; Capanna, Rodolfo; Campanacci, Domenico Andrea

doi:10.1016/j.jos.2018.06.008

Cited by 18 publications

(22 citation statements)

References 23 publications

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“…In light of these facts, population-based surveillance of rare cancers and their descriptive epidemiology provide the foundation for advancing etiological and clinical research with the ultimate goal of reducing the public health burden of rare cancers.This research focuses on the under-studied rare cancer liposarcoma. Liposarcoma is a malignant mesenchymal tumor [7], accounting for almost 20% percent of adult mesenchymal tumors [8]. It can be found anywhere in the body, but most commonly in the extremities and retroperitoneum [8].…”

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confidence: 99%

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Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Bock

Hoffmann

Jiang

et al. 2020

IJERPH

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Rare cancers, affecting 1 in 5 cancer patients, disproportionally contribute to cancer mortality. This research focuses on liposarcoma, an understudied rare cancer with unknown risk factors and limited treatment options. Liposarcoma incident cases were identified from the U.S. Surveillance, Epidemiology, and End Result (SEER) program and the combined SEER-National Program of Cancer Registries (CNPCR) between 2001-2016. Incidence rates (age-adjusted and age-specific), 5-year survival, and the time trends were determined using SEER*stat software. Three-dimensional visualization of age-time curves was conducted for males and females. SEER liposarcoma cases represented~30% (n = 11,162) of the nationwide pool (N = 37,499). Both sources of data showed males accounting for~60% of the cases; 82%-86% cases were identified among whites. Age-adjusted incidence was greater among males vs. females and whites vs. blacks, whereas survival did not differ by sex and race. The dedifferentiated (57.2%), pleomorphic (64.1%), and retroperitoneal (63.9%) tumors had the worse survival. Nationwide, liposarcoma rates increased by 19%, with the annual percent increase (APC) of 1.43% (95% confidence interval (CI): 1.12-1.74). The APC was greater for males vs. females (1.67% vs. 0.89%) and retroperitoneal vs. extremity tumors (1.94% vs. 0.58%). Thus, incidence increased faster in the high-risk subgroup (males), and for retroperitoneal tumors, the low-survival subtype. The SEER generally over-estimated the rates and time trends compared to nationwide data but under-estimated time trends for retroperitoneal tumors. The time trends suggest an interaction between genetic and non-genetic modifiable risk factors may play a role in the etiology of this malignancy. Differences between SEER and CNCPR findings emphasize the need for nationwide cancer surveillance.have a considerable impact on the overall cancer outcomes. Limited treatment options, high costs of existing treatments, and frequent misdiagnosis of rare cancers burden patients, physicians, and health systems [4]. The lack of epidemiological knowledge about the risk factors associated with many rare cancers precludes the development of viable prevention, making it one of the most dramatic unresolved public health problems [1,3,5]. In comparison, well-studied cancers such as colorectal cancer, which constitutes a smaller portion of the overall cancer cases (13%), has had significant progress in cancer control and prevention [5,6]. The existing gaps in research and treatment are reflected in rare cancer survival rates. The 5-year survival for rare cancers is worse compared to common cancers: 49% vs. 63% in Europe [5]; and the U.S., 55% vs. 75% among males and 60% vs. 74% among females [4]. In light of these facts, population-based surveillance of rare cancers and their descriptive epidemiology provide the foundation for advancing etiological and clinical research with the ultimate goal of reducing the public health burden of rare cancers.This research focuses on the under-studied rare cancer...

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confidence: 99%

“…This research focuses on the under-studied rare cancer liposarcoma. Liposarcoma is a malignant mesenchymal tumor [7], accounting for almost 20% percent of adult mesenchymal tumors [8]. It can be found anywhere in the body, but most commonly in the extremities and retroperitoneum [8].…”

mentioning

confidence: 99%

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Bock

Hoffmann

Jiang

et al. 2020

IJERPH

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“…The five-year survival rate for stage I and stage II DDL is approximately 65%, which reduces to 49% for stage III and <18% for stage IV ( Primary surgical resection with negative margins with or without subsequent neoadjuvant and adjuvant radiotherapy is recommended for soft tissue sarcomas of the extremities, superficial trunk, and head and neck areas that are resectable with acceptable functional outcomes [8]. Resection should achieve negative margins >1.0 cm and/or intact fascial planes [8,11]. Marginal resection is associated with increased rates of local recurrence, metastasis, and decreased five-year survival ( Table 3) [12].…”

Section: Discussionmentioning

confidence: 99%

Limb Salvage Resection of Massive Dedifferentiated Thigh Liposarcoma in a Patient Lost to Follow-Up

Calvo¹,

Mann²,

Lopez-Viego³

et al. 2021

Cureus

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Dedifferentiated liposarcoma (DDL) is a rare soft tissue tumor that represents a non-lipogenic progression of well-differentiated liposarcoma (WDL). Unlike WDL, DDL has the propensity for metastasis and is associated with an increased incidence of local recurrence. For DDL of the extremities that is resectable with acceptable functional outcomes, treatment includes primary surgical resection with negative margins. Although rare due to advances in reconstructive techniques, amputation for DDL of the extremities should be considered in which appropriate tumor resection cannot be performed without adequate preservation of limb function. We present the clinical progression of a patient with a large DDL of the right thigh who was initially lost to follow-up, but ultimately underwent delayed definitive therapy with the intent for limb salvage. This case illustrates the importance of assessing neurovascular, osseous, and soft tissue involvement to properly predict and preserve limb function while achieving adequate tumor resection.

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“…Liposarcomas are tumors of adipocyte origin [7]. They are categorized into atypical lipomatous/well-differentiated tumors, dedifferentiated, myxoid, and pleomorphic [8]. Lipomas and liposarcomas can have similar features on magnetic resonance imaging (MRI).…”

Section: Discussionmentioning

confidence: 99%

Parathyroid Auto-transplantation Mimicking Liposarcoma

Boron¹,

Dennison²,

Dennison³

et al. 2019

Cureus

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Parathyroid autotransplantation is an increasingly common procedure given the increasing rate of hyperparathyroidism. However, post-autotransplantation imaging is not commonly performed and the imaging findings can mimic liposarcoma. Therefore, radiologists should be aware of the imaging characteristics of parathyroid autotransplantation. Here we discuss the CT and Tc99m-Sestamibi 4D-CT findings of parathyroid autotransplantation. We will also discuss the pathophysiology of liposarcoma and present the gross histological findings seen on pathology.

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Liposarcoma: Clinico-pathological analysis, prognostic factors and survival in a series of 307 patients treated at a single institution

Cited by 18 publications

References 23 publications

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Limb Salvage Resection of Massive Dedifferentiated Thigh Liposarcoma in a Patient Lost to Follow-Up

Parathyroid Auto-transplantation Mimicking Liposarcoma

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