Lipoproteins abnormalities in obese insulin-resistant dogs

Bailhache, Edwige; Nguyen, Patrick; Krempf, Michel; Siliart, Brigitte; Magot, T.; Ouguerram, Khadija

doi:10.1053/meta.2003.50110

Cited by 62 publications

(66 citation statements)

References 36 publications

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“…This LP profile may be characteristic of dogs with insulin resistance. 2 This dyslipidemic profile, associated with excessive body fat, may predispose dogs to metabolic syndrome, as has been demonstrated in humans. 10,23,26 It is known that insulin resistance stimulates the hormone-sensitive lipase activity, which increases free fatty acid (FFA) concentration.…”

Section: Discussionmentioning

confidence: 91%

“…13,17 In dogs, HDL is the main form of CHOL transport in plasma, which represents a different HDL composition as compared with human HDL. 2,3 In most studies, fractionation of the plasma LP has been performed by ultracentrifugation using different density ranges than that established for humans. 19 The lipid profile of the control group was characteristic of healthy dogs.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 These individuals had low concentrations of VLDL-CHOL and LDL-CHOL and a high concentration of HDL-CHOL. [2][3][4][5] The higher concentration of HDL-CHOL observed in animals such as dogs and cats decreases the risk of developing atherosclerotic disease. This LP profile is attributed to the absence of CHOL ester transfer protein, which transfers CHOL ester from HDL to VLDL and TAG in the opposite way.…”

Section: Discussionmentioning

confidence: 99%

“…10,23,26 It is known that insulin resistance stimulates the hormone-sensitive lipase activity, which increases free fatty acid (FFA) concentration. 2 An increase in FFA concentration also has an important role in insulin sensitivity. The FFAs from visceral fat reach the liver through the portal-hepatic vein, where they impair insulin action on hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

“…4 However, there was no significant difference in the LDL concentrations of dogs with insulin resistance and control dogs, as observed in the present study. 2 HAC promotes the onset of metabolic syndrome, 6 which explains the change of an antiatherogenic profile, characteristic of healthy dogs, 19,20 to an atherogenic one that is prone to the development of hepatic lipidosis, pancreatitis, diabetes, neuropathies, and ophtalmopathies. 28 increased CHOL concentrations in the VLDL and LDL fractions observed in the HAC group also favor the development of atherosclerosis, 6,12,16 although a previous study in dogs has shown that diabetes mellitus and hypothyroidism have a greater propensity to develop atherogenic lesions than HAC.…”

Section: Discussionmentioning

confidence: 99%

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Chromatographic Analysis of Lipid Fractions in Healthy Dogs and Dogs with Obesity or Hyperadrenocorticism

Jericó¹,

Chiquito

Kajihara

et al. 2009

J VET Diagn Invest

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Abstract. Obesity and endogenous hyperadrenocorticism (HAC) are common clinical conditions in veterinary practice, and both conditions have clinical and laboratory similarities, such as weight gain and dyslipidemia. The objective of the present study was to characterize and compare the lipid profiles and plasma lipoprotein fractions in healthy dogs (n 5 10), in obese dogs (n 5 10), and in dogs with HAC (n 5 6). All of the dogs were client owned. The lipoproteins were separated by fast protein liquid chromatography, and the plasma concentrations of total cholesterol and total triacylglycerol (TAG) were determined by enzymatic methods. When compared with the healthy and obese groups, dogs with HAC had a significant increase (P , 0.01) in the total concentrations of TAGs and cholesterol (CHOL), with higher distribution in the very lowdensity lipoprotein (VLDL)-CHOL fractions. In addition, the distributions of the high-density lipoprotein (HDL)-CHOL and HDL-TAG fractions were significantly lower (P , 0.01) in dogs with HAC than in healthy dogs. Considering the animals in this study, it was determined that the dogs with HAC differed significantly from the healthy and obese dogs regarding the metabolism of CHOL and TAG, as well as their VLDL and HDL fractions. Similar laboratory findings could allow veterinarians to distinguish obese dogs from those with HAC. In addition, dogs with HAC may be at higher risk for developing metabolic and atherosclerotic complications.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Chromatographic Analysis of Lipid Fractions in Healthy Dogs and Dogs with Obesity or Hyperadrenocorticism

Jericó¹,

Chiquito

Kajihara

et al. 2009

J VET Diagn Invest

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Obesity in Humans and Dogs: Similarities, Links, and Differences

Tvarijonaviciute

Muñoz-Prieto

Martı́nez-Subiela

2019

Pets as Sentinels, Forecasters and Promoters of Human Health

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Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs

et al. 2011

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A common sign of obesity, in dogs, is hyperlipidemia, which is characterized by hypercholesterolemia and/or hypertriglycemia. Hyperlipidemia can be caused by a quantitative increase in circulating lipoproteins (LP) or by a higher lipid concentration in the various LP classes. In this study, we sought to determine whether aberrations occur with cholesterol lipoprotein profile, especially with sub HDL-cholesterol fraction % in obese dogs. Using clinically healthy and disease free (no overt signs) body condition score classified obese dogs, of all ages, we attempted to determine the influence of age, gender and obesity status on cholesterol lipoprotein profiling. Overall, no aberration in pattern was observed in obese dogs <8 years of age. However, in older obese animals (≥8 years of age), the general aberration pattern to cholesterol lipoprotein observed was that a significant decrease in HDL2 and 3 fraction % occurs with a concomitant increase in either HDL1-Cho or VLDL and LDL -Cho fraction % depending on gender. Linear regression analysis indicated that obesity status appears to significantly affect total cholesterol, HDL2 and 3-Cho, VLDL and LDL-Cho levels (P=0.02, 0.046, and 0.045, respectively), whereas it is borderline with HDL1-Cho (P=0.062). On the other hand, age significantly influenced TG, Total cholesterol, and HDL1-Cho levels (P=0.009, 0.006, and 0.002, respectively), while gender influenced VLDL and LDL-Cho (P=0.024) level. Therefore, aberrations in cholesterol lipoprotein profile pattern might be of potential use to assess and diagnose obesity status, in conjunction with BCS, especially of older overweight animals which might be considered borderline obese.

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Lipoproteins abnormalities in obese insulin-resistant dogs

Cited by 62 publications

References 36 publications

Chromatographic Analysis of Lipid Fractions in Healthy Dogs and Dogs with Obesity or Hyperadrenocorticism

Chromatographic Analysis of Lipid Fractions in Healthy Dogs and Dogs with Obesity or Hyperadrenocorticism

Obesity in Humans and Dogs: Similarities, Links, and Differences

Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs

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