Lipoprotein Profile Modifications during Gestation: A Current Approach to Cardiovascular risk surrogate markers and Maternal-fetal Unit Complications

Santos, Alexandre Araújo Cunha dos; Couto, Ricardo David

doi:10.1055/s-0038-1642600

Cited by 3 publications

(4 citation statements)

References 64 publications

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“…In a case-control study carried out in Dubai, which aimed to determine the association between dyslipidemia, overweight and the risk of PE, found that, mainly, hypertriglyceridemia was highly correlated with overweight in pregnancies with the disease 4 . In other study, report that in obese pregnant women dyslipidemia is more accentuated which could be justified by the fact that overweight pregnant women have greater difficulties in adapting to the metabolic change characteristic of the gestational period 6 .…”

Section: Discussionmentioning

confidence: 89%

“…A meta-analysis that evaluated cohort studies concluded that hypertriglyceridemia precedes the development of PE 3 , which is caused by the hepatic production of very low density lipoproteins (VLDL) rich in TG due to their lipolysis in adipocytes, and by the decrease in VLDL clearence due to the decrease in lipoprotein lipase (LPL) and liver lipase, being the main lipid manifestation observed in pregnancies with dyslipidemia 6 . In this study pregnant women with PE presented higher mean TG levels when compared with pregnant women without the disease, similar to the findings by Jamal et al 14 who found an average with pregnant women with the disease in Multan.…”

Section: Discussionmentioning

confidence: 99%

“…Like this, different biomarkers have been studied in the scientific community, including ferritin, uric acid, soluble endoglin, among others, in order to predict the risk of complications and / or severity of PE 5 . Therefore, it is believed that an altered lipid profile can be used as a prognostic marker for PE, as well as a risk factor for the development of the disease, since studies show that dyslipidemia may be involved in the etiopathogenesis of the disease 3,6 . Thus, the objective of this study is to evaluate the prevalence of dyslipidemia in pregnant women with PE and its relationship with adverse perinatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Dyslipidemia worsens perinatal outcomes in pregnancies with preeclampsia

Silva¹,

Ferreira²,

Moura³

et al. 2020

Braspen J

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Introdução: Estudos têm demonstrado que gestantes com pré-eclâmpsia (PE) apresentam maiores alterações no perfil lipídico quando comparadas a gestantes sem a doença, o que pode levar a desfechos perinatais adversos. Assim, o objetivo deste estudo é avaliar a prevalência de dislipidemia em gestantes com PE e sua relação com desfechos perinatais adversos. Método: Estudo transversal realizado em uma capital do Nordeste do Brasil, em 2017, com gestantes com PE e seus recém-nascidos por meio da aplicação de formulário padronizado para coleta de dados socioeconômicos, obstétricos, estilo de vida, antropométricos e perinatais e avaliação do perfil lipídico [colesterol total (TC), lipoproteína de alta densidade (HDL), lipoproteína de baixa densidade (LDL) e triglicerídeos (TG)]. A regressão de Poisson foi utilizada para avaliar a associação da dislipidemia (variável de desfecho) com a presença de desfechos perinatais (variáveis independentes), quando a magnitude das associações foi expressa em razão de prevalência (RP) e seus respectivos intervalos de confiança de 95% (IC95%), com p <0,05 sendo considerado significativo. Resultados: A prevalência de dislipidemia em gestantes com PE foi de 56,73%, estando associada ao parto cesáreo (RP: 1,52; IC 95%: 1,02-2,26 e p = 0,039) e prematuridade (RP: 1,49; IC 95%: 1,13-1,96 e p = 0,004). Conclusão: A prevalência de dislipidemia em gestantes foi elevada em gestantes com PE e aumenta a prevalência de parto cesáreo e prematuridade. Assim, a avaliação desses marcadores deve ser observada com maior atenção entre os profissionais da assistência pré-natal.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dyslipidemia worsens perinatal outcomes in pregnancies with preeclampsia

Silva¹,

Ferreira²,

Moura³

et al. 2020

Braspen J

View full text Add to dashboard Cite

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“…The prevalence of GDM, preterm birth and low birth weight differs by ethnicity, and we and others have reported ethnic differences in foetal growth [ 24 ]. Adverse lipid profiles are strongly related to cardiometabolic diseases, but of note, women with pregnancy complications like preeclampsia and GDM are also at higher risk of later cardiovascular disease (CVD) and type 2 diabetes [ 21 , 25 – 27 ]. Ethnic differences in concentrations of lipids and lipoproteins outside pregnancy are well documented, with women of South Asian origin displaying higher triglycerides, lower HDL-cholesterol and more small, dense LDL-cholesterol particles related to insulin resistance, compared with women of Western European origin [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity

Waage

Mdala

Stigum

et al. 2022

BMC Pregnancy Childbirth

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Background To describe ethnic differences in concentrations of lipids and lipoproteins, and their changes, during pregnancy to postpartum. Methods This was a population-based cohort study conducted in primary antenatal care in Norway. The participants (n = 806) were healthy, pregnant women, 59% were ethnic minorities. Outcomes were triglycerides, total cholesterol, HDL- and LDL-cholesterol, analysed from fasting blood samples drawn at gestational age (weeks) 15, 28 and 14 weeks postpartum. We performed linear regression models and linear mixed models to explore the total effect of ethnicity on the outcomes, adjusting for gestational age /week postpartum, maternal age and education. The analyses are corrected for multiple testing using the Bonferroni correction. Results At gestational age 15, triglyceride concentrations were lower in women of African origin (1.03 mmol/mol (95% CI: 0.90, 1.16)) and higher in women of South Asian (primarily Pakistan and Sri Lanka) origin (1.42 mmol/mol (1.35, 1.49)) and East Asian (primarily Vietnam, Philippines and Thailand) origin (1.58 mmol/mol (1.43, 1.73)) compared with Western Europeans (1.26 mmol/mol (1.20, 1.32)). Women of Asian and African origin had a smaller increase in triglycerides, LDL- and total cholesterol from gestational age 15 to 28. At gestational age 28, LDL-cholesterol levels were lowest among East Asians (3.03 mmol/mol (2.72, 3.34)) compared with Western Europeans (3.62 mmol/mol (3.50, 3.74)). Triglycerides and HDL-cholesterol were lower postpartum than at gestational age 15 in all groups, but the concentration of LDL-cholesterol was higher, except in Africans. South and East Asian women had lower HDL-cholesterol and higher triglycerides postpartum, while African women had lower triglycerides than Western Europeans. Conclusion We found significant differences in the concentrations of lipids and lipoproteins and their changes during pregnancy and the early postpartum period related to ethnic origin.

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Transfer Proteins, Lipoprotein Remodeling, and Antioxidant Action on Pregnant Women: Comparison from the First to the Third Trimester of Gestation

Santos,

de Alcântara,

Soares

et al. 2023

TOBIOMJ

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Introduction: During pregnancy, maternal lipid metabolism undergoes several transformations originated by hormonal changes. There are two distinct phases: initial and late, finally driven to hypertriglyceridemia. Maternal hyperlipidemia, especially hypertriglyceridemia, is associated with an increased hepatic very-low-density lipoprotein (VLDL) synthesis stimulated by high estrogen levels during gestation. Objectives: This study aimed to evaluate the action of possible lipoproteins remodeling modulators, such as phospholipid and cholesteryl-ester transfer proteins (PLTP and CETP), paraoxonase-1 (PON-1), and apolipoproteins (apo), during gestation. Methods: An observational prospective cohort study composed of 40 pregnant women was conducted. Blood samples were collected in two moments: at the first and third trimesters of gestation, followed by the biochemical determination of apo A-I, apo B, lipid profile, PON-1, PLTP and CETP activities, and HDL particle size. Results: The majority of pregnant women in the third trimester showed dyslipidemia, mainly hypertriglyceridemia. In the third trimester of gestation, we observed an increase in CETP activity (70.5 ± 9.6 pmol/µL/h; p <0.001) and TG/HDL-C ratio (2.7 [2.0-3.8]), but on the other hand, PON-1 activity (65.4 [46.5-105] nMol of p-nitrophenol/min/mL) decreased. High-density level lipoprotein (HDL) particle size and PLTP activity did not differ in the two studied moments. The serum triglyceride concentration and CETP activity showed a positive linear correlation in the first trimester of gestation (r2=0.65, p<0.001). Conclusion: Data suggest that the CETP activity, antioxidant profile, and low-density lipoprotein (LDL) remodeling are modified by physiological metabolic changes during an uncomplicated gestational period.

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Lipoprotein Profile Modifications during Gestation: A Current Approach to Cardiovascular risk surrogate markers and Maternal-fetal Unit Complications

Cited by 3 publications

References 64 publications

Dyslipidemia worsens perinatal outcomes in pregnancies with preeclampsia

Dyslipidemia worsens perinatal outcomes in pregnancies with preeclampsia

Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity

Transfer Proteins, Lipoprotein Remodeling, and Antioxidant Action on Pregnant Women: Comparison from the First to the Third Trimester of Gestation

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