Lipoprotein particle abnormalities and the impaired lipolysis in renal insufficiency

Lee, Diana M.; Knight-Gibson, Carolyn; Samuelsson, Ola; Attman, Per‐Ola; Wang, Chi-Sun; Alaupovic, Petar

doi:10.1046/j.1523-1755.2002.00116.x

Cited by 68 publications

(55 citation statements)

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“…11 Substances from visceral fat can alter glomerular function and may play an important role in pathogenesis. 31 Further studies on causality between visceral adiposity and renal injury are warranted. In summary, our study shows that even in apparently ESRD patients those with central fat distribution have a greater risk of diminished renal filtration.…”

Section: Discussionmentioning

confidence: 99%

Association of Conicity Index and Renal Progression in Pre-dialysis Chronic Kidney Disease

2012

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Background/objectives: Abdominal fat deposition is represented by means of the conicity index (CI), an anthropometric estimate that models the relative accumulation of abdominal fat. We examined the influence of markers of cardiovascular disease in terms of inflammation and lipid profile and body fat distribution on the progression of renal disease in patients with stable chronic kidney disease (CKD) stages 3-5. Material and methods: We studied 104 pre-dialysis CKD patients (64 males, 62%; age 64.6 ± 14.7 years). Glomerular filtration rate (GFR) was estimated (44.62 ± 14.38 mL/min/1.73 m 2 ) by modification of diet in renal disease formula. GFR values were estimated at baseline and at the end of the 12-month follow-up. Patients were stratified into three groups: group 1 had a loss of GFR ≥20%; group 2 had a loss of GFR 10-20%; and group 3 patients had stable renal functions or GFR change <10% at the end of 12 months. Body mass index (BMI), waist/hip ratio (WHR), and CI were subsequently computed. Renal resistive index (RRI) was measured using Doppler ultrasonography. Results: CI was strongly correlated with total cholesterol (r = 0.37, p < 0.01), low-density lipoprotein (LDL) (r = 0.53, p < 0.01), C-reactive protein (r = 0.21, p < 0.05), and serum potassium (r = 0.216, p < 0.02), whereas BMI and WHR were not associated with these parameters. The values of CI, serum cholesterol, LDL, alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase activity, the degree of proteinuria and microalbuminuria, and RRI were significantly lower in group 3. In linear regression model, LDL (r 2 = 0.17, p = 0.02), uric acid (r 2 = 0.19, p < 0.01), and RRI (r 2 = 0.64, p < 0.01) were independently associated with CI for all groups. Conclusion: CI is an independent predictor of systemic inflammation, cardiovascular risk, and GFR in patients during the pre-dialysis period.

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Section: Discussionmentioning

confidence: 99%

Association of Conicity Index and Renal Progression in Pre-dialysis Chronic Kidney Disease

2012

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“…Thus, the presence of IR may further exacerbate the lipid abnormalities associated with CKD. Accumulation of intact and/or partially metabolized triglyceride-rich apoB-containing lipoproteins (TRLs) in CKD has been related to defective lipolytic degradation ( 30 ). Elevated total plasma apoC-III concentration and accumulation of apoC-III in VLDL particles can occur in early CKD ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Chronic kidney disease delays VLDL-apoB-100 particle catabolism: potential role of apolipoprotein C-III

Chan

Dogra

Irish

et al. 2009

Journal of Lipid Research

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“…Rather, their lipoprotein profiles are characterized by reduced HDL-cholesterol (HDL-C) and elevated triglyceride (TG)-rich lipoprotein concentrations (3)(4)(5)(6). In addition, the enzymes and transfer proteins involved in lipoprotein metabolism tend to exhibit lowered activity in HD patients (4,5,(7)(8)(9)(10). These abnormalities may contribute significantly to the high frequency of CVD occurrence in HD patients.…”

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confidence: 99%

LCAT-Dependent Conversion of Preβ1-HDL into α-Migrating HDL is Severely Delayed in Hemodialysis Patients

Miida¹,

Miyazaki²,

Hanyu

et al. 2003

Journal of the American Society of Nephrology

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Abstract. Pre␤1-HDL is a minor HDL subfraction that acts as an efficient initial acceptor of cell-derived free cholesterol. During 37°C incubation, plasma pre␤1-HDL decreases over time due to its conversion to ␣-migrating HDL by lecithin: cholesterol acyltransferase (LCAT). This conversion may be delayed in hemodialysis patients who have decreased LCAT activity. To clarify whether LCAT-dependent conversion of pre␤1-HDL to ␣-migrating HDL is delayed in hemodialysis patients, pre␤1-HDL concentrations were determined in 45 hemodialysis patients and 45 gender-matched control subjects before and after 37°C incubation with and without the LCAT inhibitor. It was found that the baseline pre␤1-HDL concentration in hemodialysis patients was more than twice that in the controls (44.9 Ϯ 21.4 versus 19.8 Ϯ 6.7 mg/L apoAI; P Ͻ 0.001). After 2-h incubation, the LCAT-dependent decrease in pre␤1-HDL in hemodialysis patients was about one-third of that in the controls (30 Ϯ 27 versus 97 Ϯ 17% of baseline; P Ͻ 0.01). The LCAT-dependent rate of decrease in pre␤1-HDL levels (DR pre␤1 ) was the same for samples from hemodialysis patients exhibiting normal (Ն1.03 mmol/L) and low HDLcholesterol levels (32 Ϯ 32 versus 28 Ϯ 23% of baseline; NS). DR pre␤1 was positively correlated with LCAT activity (r ϭ 0.617; P Ͻ 0.001). In conclusion, the LCAT-dependent conversion of pre␤1-HDL to ␣-migrating HDL is severely delayed in hemodialysis patients. The impaired catabolism of pre␤1-HDL may accelerate atherosclerosis in hemodialysis patients.

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Lipoprotein particle abnormalities and the impaired lipolysis in renal insufficiency

Cited by 68 publications

References 50 publications

Association of Conicity Index and Renal Progression in Pre-dialysis Chronic Kidney Disease

Association of Conicity Index and Renal Progression in Pre-dialysis Chronic Kidney Disease

Chronic kidney disease delays VLDL-apoB-100 particle catabolism: potential role of apolipoprotein C-III

LCAT-Dependent Conversion of Preβ1-HDL into α-Migrating HDL is Severely Delayed in Hemodialysis Patients

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