Lipoprotein lipase mass and activity in post‐heparin plasma from subjects with intra‐abdominal visceral fat accumulation

Abstract

Fat distribution affects LPL mass and activity, either directly or via another metabolic abnormality such as insulin resistance, leading to impaired hydrolysis of triglycerides in chylomicrons and very low density lipoproteins (VLDL) in these subjects.

Serum lipoprotein lipase mass: Clinical significance of its measurement

“…Several clinical studies were conducted for analyzing the relationship of LPL mass, either in pre-heparin plasma (or serum) or PHP, to visceral fat accumulation. We and other groups have reported that intra-abdominal visceral fat area assessed by CT at umbilical level had an inverse relationship to LPL mass and activity in PHP [26][27][28]. Similar results were obtained on the association between intra-abdominal visceral fat and pre-heparin LPL mass [19] by recruiting a total of 58 subjects comprising 50 hyperlipidemic and 8 normolipidemic subjects.…”

Mechanisms by which diabetes increases cardiovascular disease

“…LPL mass and activity in post heparin plasma not only correlate inversely with triglycerides and non-enzymatically glycated haemoglobin (HbA1c) in type 2 diabetics, but also with insulin resistance [67] and future coronary artery disease even after adjustment for traditional risk factors like blood pressure, LDL serum levels, diabetes or body mass index [68]. LPL seems to be an excellent marker integrating type 2 diabetes and atherogenesis, but there are currently no studies testing for LPL inhibition in order to prevent cardiovascular disease.…”

Effects of Calorie-Restricted Low-Carbohydrate Diet on Glucose and Lipid Metabolism in Otsuka Long Evans Tokushima Fatty Rats

“…The mechanism of theses changes is unclear. Probably, a low-carbohydrate diet and pioglitazone could promote mRNA expression of LPL in subcutaneous adipose tissue, because the expression of the LPL gene was decreased in subcutaneous adipose tissues 30) . It is reported that after a hypocaloric diet, no significant change in mRNA expression of leptin in subcutaneous adipose tissue was observed 31) .…”