Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population

Tanguturi, Parthasaradhireddy; Pullareddy, Bhoomireddy; Krishna, B.; Murthy, Dwarkanath K.

doi:10.1016/j.ihj.2013.10.004

Cited by 17 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We could observe that as previous studies, in this study, there were associations between demographic risk factors (smoking, hypertension, hyperlipidemia, TG> 200 mg/dl and HDL<40 mg/dl) and CAD. 2 , 9 , 12 , 14 , 15 These risk factors were due to the increase in the susceptibility to CAD. Smoking had the most influence on this disease ( smoking: P <0.001, OR=3.256, 95% CI=1.781-5.953; hypertension: P =0.025, OR=1.952, 95% CI=1.086-3.508; hyperlipidemia: P =0.004, OR=2.347, 95% CI=1.315-4.189; TG>200 mg/dl: P =0.004, OR=2.345, 95% CI=1.321-4.161; HDL<40 mg/dl: P =0.024, OR=1.917, 95% CI=1.090-3.372).…”

Section: Discussionmentioning

confidence: 99%

The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City

Ahmadi¹,

Senemar²,

Toosi³

et al. 2015

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

Introduction: Several polymorphisms at the lipoprotein lipase (LPL) locus are associated with variations in LPL activity serum lipid concentrations and the risk of coronary artery disease (CAD). The aim of this study was to investigate the role of the LPL S447X and HindIII polymorphism in a sample of subjects with CAD and compare them with healthy subjects. Methods: The study enrolled 115 patients and 89 healthy subjects who were recruited from Namazi hospital in 2010-2012. The presence of two common polymorphisms of the LPL gene (HindIII and S447X) was determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis using genomic DNA. SPSS 16.0 was used for statistical analysis. Results: S447X was significantly different between the patients with CAD and the healthy subjects (P < 0.001). But HindIII was not significantly different between the patients with CAD and the healthy subjects (P = 0.741). Risk factors such as smoking, hypertension, hyperlipidemia, triglyceride (TG) and high-density lipoprotein (HDL) levels had a significant association with CAD. Conclusion: In our study, the presence of G allele S447X polymorphism increases the TG level and decrease HDL level, so it increases the susceptibility CAD. Moreover, HindIII polymorphism did not have any significant association with CAD.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City

Ahmadi¹,

Senemar²,

Toosi³

et al. 2015

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

show abstract

“…Several polymorphisms in the LPL gene have been shown to lead to a reduction in enzyme synthesis and activity and, to date, rs320 [ HindIII (G/T)] and rs328 [ Serine 447 Stop S447X (C/G)] have been the most extensively studied. These variants with a prevalence of 40%–75% (rs320) and 17%–22% (rs328) among Caucasians [ 8 , 9 ], respectively, have been shown to be associated with coronary artery disease, myocardial infarction [ 10 , 11 , 12 ] and pronounced fasting hypertriacylglycerolemia [ 13 , 14 ]. Only limited number of studies has examined their impact on postprandial lipaemia [ 15 , 16 , 17 ] and these studies have used only a single test meal, which does not reflect the habitual eating pattern in humans.…”

Section: Introductionmentioning

confidence: 99%

Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion

Shatwan

Minihane

Williams

et al. 2016

IJMS

View full text Add to dashboard Cite

Lipoprotein lipase (LPL) is a key rate-limiting enzyme for the hydrolysis of triacylglycerol (TAG) in chylomicrons and very low-density lipoprotein. Given that postprandial assessment of lipoprotein metabolism may provide a more physiological perspective of disturbances in lipoprotein homeostasis compared to assessment in the fasting state, we have investigated the influence of two commonly studied LPL polymorphisms (rs320, HindIII ; rs328, S447X ) on postprandial lipaemia, in 261 participants using a standard sequential meal challenge. S447 homozygotes had lower fasting HDL-C ( p = 0.015) and a trend for higher fasting TAG ( p = 0.057) concentrations relative to the 447X allele carriers. In the postprandial state, there was an association of the S447X polymorphism with postprandial TAG and glucose, where S447 homozygotes had 12% higher TAG area under the curve (AUC) ( p = 0.037), 8.4% higher glucose-AUC ( p = 0.006) and 22% higher glucose-incremental area under the curve (IAUC) ( p = 0.042). A significant gene–gender interaction was observed for fasting TAG ( p = 0.004), TAG-AUC ( P interaction = 0.004) and TAG-IAUC ( P interaction = 0.016), where associations were only evident in men. In conclusion, our study provides novel findings of an effect of LPL S447X polymorphism on the postprandial glucose and gender-specific impact of the polymorphism on fasting and postprandial TAG concentrations in response to sequential meal challenge in healthy participants.

show abstract

“…H¯allele was associated with lower levels of triglycerides and higher HDL-c in a southern Brazilian population of European descent and also the H¯ haplotypes was associated with a significant protective effect against in coronary artery disorders in male subjects 64 . Similar results, like LPL H + H + genotype, was a risk factor for myocardial infarction in Brazil and Russian population 65 and significantly associated with myocardial infarction (MI) patients in South Indian population 66 , but these polymorphic studies are very limited in India. In another study observed H¯ (G) allele was not associated with blood lipids or cardiovascular events 67 and also a recent study conducted by Marcia et al reported H + /H + (T/T) genotype and the H + (T) allele were associated with elevated VLDLc and triglycerides levels (P < 0.05) and reduced HDL-C levels (P < 0.05) 68 .…”

Section: Atherogenic Ratios Like Castelli's Risk Index-i (Cri-i)mentioning

confidence: 67%

Association of Lipid Profile, Atherogenic Indices, and LPL Hind-III Gene Polymorphism with Coronary Artery Disease Positive Subjects

Ranjit

Guntuku

Pothineni³

2017

IJPCR

View full text Add to dashboard Cite

Dyslipidemia is renowned as a prominent risk factor for the development of atherosclerosis and associated cardiovascular diseases such as formation of plaques in arteries, atherosclerosis, myocardial infarction, sudden coronary death, stable angina and unstable angina. CAD may be due to dysfunctional mutations in lipoproteins or lipoprotein-related genes. Lipoprotein lipase (LPL) plays an important role in lipid metabolism. Our aim of the present study is to determine the association and prediction of risk cases by using atherogenic indices and Hind-III LPL gene polymorphism. Atherogenic indices are a powerful indicator to predict the risk of coronary artery diseases. The atherogenic indices of CAD negative and positive are CRI-I (4.68±0.08; 6.46±0.12), CRI-II (3.03±0.06; 3.99±0.15), TG/HDL-c (3.27±0.19; 7.40±0.62), AIP (0.45±0.02; 0.81±0.03) and AC (3.68±0.08; 5.39±0.13) observed respectively. These results indicate atherogenic indices are may be useful for identifying an individual at higher risk of cardiovascular disease in the clinical practices especially and not markedly deranged or in centers with insufficient resources to predict the CVS risk. In the case of Hind-III LPL gene polymorphism; TT genotype frequency was found to be significantly higher in CAD positive subjects than the controls and CAD negative subjects. More than threefold was increased risk for CAD development under the codominant model. Correspondingly, the T allele frequency of intron 8 T >G polymorphism was elevated in CAD positive subjects (95 % CI; 2.19 (1.28- 3.75) p=0.003) compared to controls. LPL intron 8 T >G gene polymorphism (rs320) results support the above data; T allele (H+ ) was associated with various cardiovascular risks such as positively correlated with carotid artery atherosclerosis, higher risk of myocardial infarction and higher plasma triglycerides and lower HDL-cholesterol.

show abstract

Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population

Abstract: Our study strongly suggests that the LPL gene HindIII Hþ Hþ genotype is an independent risk factor for first MI.

Cited by 17 publications

References 23 publications

The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City

The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City

Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion

Association of Lipid Profile, Atherogenic Indices, and LPL Hind-III Gene Polymorphism with Coronary Artery Disease Positive Subjects

Contact Info

Product

Resources

About