Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins

Nikkilä, Esko A.; Taskinen, Marja‐Riitta; Rehunen, S.; Härkönen, Matti

doi:10.1016/0026-0495(78)90288-3

Cited by 333 publications

(128 citation statements)

References 35 publications

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“…The mechanism was not clearly explained, but the decrease in leptin concentration was due to % body fat, the size of fat cells, adrenal cortex, body fat mass, resistance of leptin, insulin, thyroid gland, and changes of growth hormone, and how these factors were affected by exercise. In agreement with Gutin et al 18) and Haluzik et al 19) , in the present study there was a significant decrease in blood leptin concentration in the exercise group compared to the control.…”

Section: Discussionsupporting

confidence: 94%

“…However, it has been reported that TG concentration was not changed following endurance exercise 17) . Although controversial, most studies have shown that regular exercise reduces TG concentration due to a decline in TG flow rate, the fast use of TG for energy, and increases in the activity of decomposition of skeletal muscles and fat tissues 18) .…”

Section: Discussionmentioning

confidence: 99%

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Effect of Exercise Therapy on the Body Composition and Blood Components of Obese Men

Lee

2011

J Phys Ther Sci

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Abstract.[Purpose] The purpose of this study was to examine the effects of an eight-week exercise program on body composition, blood lipids, and hormone levels of 16 obese adult males. [Subjects and Methods] After an experimental group (n=8) and a control group (n=8) were organized, subject were examined: then, the experimental group performed endurance exercises for 8 weeks. At the end of the eight weeks, the two groups were examined again for weight, % body fat, and body fat mass via a bioelectrical impedance analysis (BIA). A blood sample was collected the day before the exercise program. Right after the exercise program, 5 ml of blood was collected and then centrifuged for 10 min at 3000 rpm. The centrifuged samples were stored at -73°C and sent to Green Cross for analysis; TC, TG, leptin, and insulin were analyzed.[Results] The experimental group showed a statistically significant decrease in % body fat and body fat mass as well as significant reductions in TC and TG and leptin concentrations. There was also a decrease in the exercise group's insulin concentration but is was not significant. [Conclusion] Eight weeks of exercise therapy increased energy consumption resulting in favorable changes in the body composition, blood lipid metabolism, and hormone levels in obese adult males.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Effect of Exercise Therapy on the Body Composition and Blood Components of Obese Men

Lee

2011

J Phys Ther Sci

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“…For example Schwartz and Brunzell [18] presented evidence suggesting that adipose lipoprotein lipase activity is increased during body fat loss by caloric restriction, and Nikkilä et al [19] found a significant positive correlation between adipose lipoprotein lipase activity and plasma HDL-C and HDL2 concentrations. Further, a pronounced elevation in adipose lipoprotein lipase activity was found in approximately half of the active runners examined by Nikkilä [20].…”

Section: Hdl Change and Body Compositionmentioning

confidence: 94%

Does weight loss cause the exercise-induced increase in plasma high density lipoproteins?

et al. 1983

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Studies showing an increase in plasma concentration of high density lipoprotein cholesterol (HDL-C) with moderate exercise have usually rejected the role of body weight change in the HDL-C raising process, ostensibly because the amount of weight lost has been negligible. To investigate HDL-C changes more thoroughly, we followed initially sedentary middle-aged men randomly assigned to either a moderate running (N= 36) or a sedentary control (N = 28) group for one year. Among runners, one-year changes in plasma HDL-C concentrations correlated strongly with their body weight changes (r = -0.53, P < 0.001). Curve-fitting procedures and regression analysis suggested that processes associated with weight change produce much of the plasma HDL-C changes induced by moderate exercise and that changes in HDL-C concentration predominantly reflect changes in the reputedly anti-atherogenic HDL2 sub-component. Further, the interaction between weight change and plasma HDL-C concentration was significantly different (P < 0.001) in exercisers and controls suggesting that the metabolic consequences of exercise-induced weight change are different from the consequences of weight change in the sedentary state.

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“…However, it is likely that subjects with the metabolic syndrome would also benefit from exercise as do other individuals with dyslipidaemia. Exercise training increases the ability of muscle tissue to take up and oxidize non-esterified fatty acids and increases the activity of lipoprotein lipase (LPL) in muscle [139,146,147]. The combined effects of exercise and diet among NIDDM subjects resulted in a decrease in total and LDL-cholesterol, while HDL-cholesterol increased (for review [148]).…”

Section: Dyslipidaemiamentioning

confidence: 99%

Exercise and the metabolic syndrome

1997

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One of the first people to introduce the metabolic syndrome -or trisyndrome mé tabolique -in the scientific literature was Camus in 1966 [1]. However, this entity did not receive much interest until Reaven in 1988 introduced syndrome X, characterised by hypertension, impairment in glucose and lipid metabolism and insulin resistance [2]. The metabolic syndrome -also called the insulin resistance syndrome -is a multifaceted syndrome characterised by five major abnormalities: obesity, hypertension, insulin resistance, glucose intolerance (impaired glucose tolerance/non-insulin-dependent diabetes mellitus (NIDDM)), and dyslipidaemia (hypertriglyceridaemia and low HDL-cholesterol). In addition, a number of other abnormalities such as microalbuminuria, hyperuricaemia, hyperfibrinogenaemia and increased levels of plasminogen activator inhibitor I and low concentrations of tissue plasminogen activator are often associated with the syndrome. The clinical importance of the metabolic syndrome is mainly due to the clustering of simultaneously occurring atherosclerotic risk factors in the same individual [2][3][4][5][6][7][8][9].The aetiology of the metabolic syndrome is poorly understood; both genetic and environmental factors are involved [2][3][4][5][6][7][8][9]. Possible common denominators for the various components of the syndrome are not known, although hyperinsulinaemia/insulin resistance are important characteristics in most of the abnormalities.The prevalence rate of the metabolic syndrome varies depending on the population studied and the definition applied. As in any syndrome, not all features are present in the same individual. The estimated prevalence rate of the metabolic syndrome in western countries is 25-35 % [2-9]. On the other hand, both Ferrannini and Rupp [8, 9] have reported that only about one-third of an adult study population was free of all major characteristics of the metabolic syndrome. Since the prevalence of hypertension, insulin resistance and glucose intolerance usually increase with increasing age, the prevalence of the metabolic syndrome will probably also rise in the aging western society.A number of pharmacological therapies can be used for the treatment of the metabolic syndrome; but the results of most of the available therapies are often unsatisfactory, although some trials with metformin and thiazolidinediones have been encouraging [6, 10, 11].Low levels of physical activity are related to most components of the metabolic syndrome [12][13][14][15][16]. Consequently this offers a unique opportunity to employ increased physical activity in the prevention and treatment of the metabolic syndrome and its components. This review will focus on the role of physical activity and exercise in the prevention and treatment of the metabolic syndrome. ObesityThe prevalence of obesity (body mass index (BMI) > 27 kg/m 2 ) is currently 25-35 % in most western societies, and is increasing [17]. If the prevalence continues to increase, as during the past decades, by the year 2230, 100 % of the adult Uni...

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Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins

Cited by 333 publications

References 35 publications

Effect of Exercise Therapy on the Body Composition and Blood Components of Obese Men

Effect of Exercise Therapy on the Body Composition and Blood Components of Obese Men

Does weight loss cause the exercise-induced increase in plasma high density lipoproteins?

Exercise and the metabolic syndrome

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