Lipoprotein Lipase

Mead, James R.; Ramji, Dipak Purshottam

doi:10.1002/0471203076.emm0742

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Lipoprotein lipase is one of the key enzymes regulating TG and lipoprotein metabolism and is mostly found in adipose tissue and skeletal muscle (Mead et al, 2002). It has been shown that lipoprotein lipase activity in adipose tissue is higher in obese than in lean individuals at rest (Poirier & Despres, 2001) and it is also known to become metabolically active for several hours after exercise cessation (Kantor et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Beneficial changes in energy expenditure and lipid profile after eccentric exercise in overweight and lean women

Paschalis

Nikolaidis

Giakas

et al. 2010

Scandinavian Med Sci Sports

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The aim was to compare lean and overweight females in regard to the effects of eccentric exercise on muscle damage indices, resting energy expenditure (REE) and respiratory quotient (RQ) as well as blood lipid and lipoprotein profile. Lean and overweight females (deviated by their body mass index) performed an eccentric exercise session. Muscle damage, energy cost and lipid profile were assessed pre-exercise and up to 72 h post-exercise. After eccentric exercise (i) muscle damage indices were affected more in the overweight subjects compared with the lean subjects; (ii) the elevation of absolute and relative REE was larger and more prolonged in the overweight group compared with the lean group; (iii) after 24 h, RQ had significantly declined, with the overweight subjects exhibiting a larger reduction compared with the lean group; and (iv) the blood lipid profile was favorably modified, with the overweight group exhibiting more favorable responses compared with the lean group. The differences between the lean and the overweight subjects may be partly due to the fact that overweight individuals experienced greater muscle damage than lean individuals. Eccentric exercise may be a promising lifestyle factor to combat obesity and dyslipidemias.

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Section: Discussionmentioning

confidence: 99%

Beneficial changes in energy expenditure and lipid profile after eccentric exercise in overweight and lean women

Paschalis

Nikolaidis

Giakas

et al. 2010

Scandinavian Med Sci Sports

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“…The mature LPL protein consists of 448 amino acids with a molecular weight of 55 kDa after resecting the signal peptide (Wong & Schotz 2002). The enzyme is active as a non‐covalent homodimer and is bound to the surface of endothelial cells via glycosaminoglycans, from where it can be released by heparin (Mead, Irvine & Ramji 2002). Lipoprotein lipase plays a key role in lipid metabolism by hydrolysing triglycerides from chylomicrons and very low‐density lipoproteins (VLDL) to non‐esterified fatty acids and 2‐monoacylglycerol, which are utilized either for storage or for energy production (Wang, Hartsuck & McConathy 1992).…”

Section: Introductionmentioning

confidence: 99%

“…Lipoprotein lipase plays a key role in lipid metabolism by hydrolysing triglycerides from chylomicrons and very low‐density lipoproteins (VLDL) to non‐esterified fatty acids and 2‐monoacylglycerol, which are utilized either for storage or for energy production (Wang, Hartsuck & McConathy 1992). The abnormalities in LPL function have been found to be associated with a number of pathophysiological conditions, including atherosclerosis, chylomicronaemia, obesity, Alzheimer's disease and dyslipidaemia associated with diabetes, insulin resistance and infection (Mead et al . 2002).…”

Section: Introductionmentioning

confidence: 99%

Cloning and expression analysis of a cDNA encoding lipoprotein lipase from the liver of adult grass carp (Ctenopharyngodon idella)

Cheng

Meng

Sun

et al. 2009

Aquaculture Research

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A full-length cDNA coding lipoprotein lipase (LPL) was cloned from the liver of adult grass carp (Ctenopharyngodon idella) using reverse transcription polymerase chain reaction (RT-PCR) and rapid ampli-¢cation of cDNA ends approaches. The cDNA obtained was 2414 bp long with a 1524 bp open reading frame encoding 507 amino acids, including a putative signal peptide 21 amino acids long. The LPL protein has a calculated molecular weight of 57.77 kDa and an isolectric point of 8.132. The main domains of LPL, such as catalytic site, disulphide bridge, N-linked glycosylation site, heparin-binding domain, lipid-binding site and site of dimer formation, are basically conserved between the grass carp and other vertebrates. The tissue distribution of LPL mRNA in the liver, head kidney, mesenteric adipose tissue, heart and white muscle of adult grass carp was analysed using the semi-quantitative RT-PCR method using b-actin gene as an internal control; the result showed that the expressions of LPL mRNAwere detected in all examined tissues of adult grass carp. The expression levels of LPL in the mesenteric adipose tissue were the highest among these tissues, followed by the liver and head kidney and the lowest expression was found in the heart and white muscle. RACE, rapid ampli¢cation of cDNA ends; 3 0 RACE, rapid ampli¢cation of the 3 0 end; 5 0 RACE, rapid ampli¢cation of the 5 0 end; LPL, lipoprotein lipase; RT-PCR, reverse transcription polymerase chain reaction; AP, anchor primer.A cDNA encoding LPL from liver of adult grass carp H-L Cheng et al.

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“…Several lines of evidence (reviewed by us in [34][35][36]) have shown that the LPL expressed by macrophages is pro-atherogenic. Such an action involves both its catalytic activity and a non-catalytic bridging function that leads to the accumulation, and thereby uptake, of lipoproteins [34][35][36]. We found that TGF-β inhibits LPL mRNA expression, protein levels and enzymatic activity in a range of macrophage sources from different species, including human monocyte-derived macrophages [30].…”

Section: Molecular Mechanisms Underlying the Tgf-β-mediated Regulatiomentioning

confidence: 99%

Transforming growth factor-β-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis

Ramji

Singh

Foka

et al. 2006

Biochemical Society Transactions

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The regulation of macrophage cholesterol homoeostasis is of crucial importance in the pathogenesis of atherosclerosis, an underlying cause of heart attack and stroke. Several recent studies have revealed a critical role for the cytokine TGF-beta (transforming growth factor-beta), a key regulator of the immune and inflammatory responses, in atherogenesis. We discuss here the TGF-beta signalling pathway and its role in this disease along with the outcome of our recent studies on the action of the cytokine on the expression of key genes implicated in the uptake or efflux of cholesterol by macrophages and the molecular mechanisms underlying such regulation.

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Lipoprotein Lipase

Cited by 4 publications

References 21 publications

Beneficial changes in energy expenditure and lipid profile after eccentric exercise in overweight and lean women

Beneficial changes in energy expenditure and lipid profile after eccentric exercise in overweight and lean women

Cloning and expression analysis of a cDNA encoding lipoprotein lipase from the liver of adult grass carp (Ctenopharyngodon idella)

Transforming growth factor-β-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis

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