Lipoprotein composition in patients with type 1 diabetes mellitus: Impact of lipases and adipokines

Hughes, Thomas A.; Calderon, Rossana M.; Diaz, Sylvia; Mendez, Armando J.; Goldberg, Ronald

doi:10.1016/j.jdiacomp.2016.01.018

Cited by 10 publications

(12 citation statements)

References 42 publications

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“…In our sample of T1DM individuals from a Mediterranean region of Spain, a decrease in the total number of atherogenic lipoproteins and an increase in the antiatherogenic ones was shown vs. non-diabetic counterparts (p < 0.001 for all comparisons, Table 2 ). However, previous studies have reported conflicting results, either using conventional biochemical analysis [ 9 ], liquid chromatography [ 10 , 11 ], proteomic analysis [ 29 ] or RMN-advanced procedures [ 12 – 16 ]. Overall, although the majority of the studies showed a better overall lipid profile among T1DM individuals [ 9 – 13 , 16 ], two independent studies suggested that this population could have proatherogenic changes in the lipoproteins [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, previous studies have reported conflicting results, either using a b conventional biochemical analysis [9], liquid chromatography [10,11], proteomic analysis [29] or RMN-advanced procedures [12][13][14][15][16]. Overall, although the majority of the studies showed a better overall lipid profile among T1DM individuals [9][10][11][12][13]16], two independent studies suggested that this population could have proatherogenic changes in the lipoproteins [14,15]. Specifically, higher amounts of total LDL-P and small HDL-P were found in adolescents [15], and an enrichment in triglyceride content (vs. cholesterol) in all the lipoprotein classes was found in adults with T1DM [14].…”

Section: Differences In Nmr Advanced Lipoprotein Profile According Tomentioning

confidence: 99%

“…In contrast, no sign of the subtle proatherogenic changes suggested in the previous studies [14,15] was found in our sample, as the triglyceride content of the main lipoprotein classes was not increased (or even decreased in the case of LDL-P), and the mean size of the HDL-P was significantly higher in the T1DM group. Some differences between the previous studies and ours should be acknowledged, such as the inclusion of an older cohort that may not be representative of the current management of T1DM (either in glucose or CVD risk factor control) [9,16], the limited sample size [10][11][12][13][14], or the strict inclusion criteria of the patients [15].…”

Section: Differences In Nmr Advanced Lipoprotein Profile According Tomentioning

confidence: 99%

“…Advancing the understanding of the underlying lipoprotein disturbances, therefore, seems to be crucial to tackle CVD in this high-risk population beyond glycaemic control [8]. However, the information regarding the differences in the lipoprotein profile among T1DM vs. their non-diabetic counterparts is scarce and conflicting results are reported [9][10][11]. In addition, advanced procedures to study these lipoprotein differences in depth (i.e., nuclear magnetic resonance (NMR) spectroscopy) have been used in only a few studies, with small samples and heterogeneous results [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Amor

Castelblanco

Hernández

et al. 2020

Cardiovasc Diabetol

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Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with non-diabetic counterparts. Methods: This cross-sectional study involved 508 adults with T1DM and 347 controls, recruited from institutions in a Mediterranean region of Spain. Conventional and advanced (assessed by nuclear magnetic resonance [NMR] spectroscopy) lipoprotein profiles were analysed. Crude and adjusted (by age, sex, statin use, body mass index and leukocyte count) comparisons were performed. Results: The median (interquartile range) age of the study participants was 45 (38-53) years, 48.2% were men. In the T1DM group, the median diabetes duration was 23 (16-31) years, and 8.1% and 40.2% of individuals had nephropathy and retinopathy, respectively. The proportion of participants with hypertension (29.5 vs. 9.2%), and statin use (45.7% vs. 8.1%) was higher in the T1DM vs. controls (p < 0.001). The T1DM group had a better conventional (all parameters, p < 0.001) and NMR-lipid profile than the control group. Thus, T1DM individuals showed lower concentrations of atherogenic lipoproteins (VLDL-particles and LDL-particles) and higher concentrations of anti-atherogenic lipoproteins (HDL-particles) vs. controls, even after adjusting for several confounders (p < 0.001 for all). While non-diabetic women had a more favourable lipid profile than non-diabetic men, women with T1DM had a similar concentration of LDL-particles compared to men with T1DM (1231 [1125-1383] vs. 1257 [1128-1383] nmol/L, p = 0.849), and a similar concentration of small-LDL-particles to non-diabetic women (672.8 [614.2-733.9] vs. 671.2 [593.5-761.4] nmol/L, respectively; p = 0.790). Finally, T1DM individuals showed higher discrepancies between NMR-LDL-particles and conventional LDLcholesterol than non-diabetic subjects (prevalence of LDL-cholesterol < 100 mg/dL & LDL-particles > 1000 nmol/L: 38 vs. 21.2%; p < 0.001). All these differences were largely unchanged in participants without lipid-lowering drugs (T1DM, n = 275; controls, n = 317).

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Section: Discussionmentioning

confidence: 99%

Section: Differences In Nmr Advanced Lipoprotein Profile According Tomentioning

confidence: 99%

Section: Differences In Nmr Advanced Lipoprotein Profile According Tomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Amor

Castelblanco

Hernández

et al. 2020

Cardiovasc Diabetol

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“…Thus, insulin therapy may reduce VLDL production by inhibiting the release of free fatty acids and by the absence of a direct inhibitory effect on the liver, which may partially explain these results. Nevertheless, some authors have suggested that hepatic lipase would be reduced (or at least not affected) in T1DM subjects, resulting in an inverse association between the hepatic lipase activity and the triglyceride content of lipoproteins [39,40].…”

Section: Discussionmentioning

confidence: 99%

Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study

Llauradó

Amigó

Cano

et al. 2019

JCM

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Background: Dyslipidemia has been associated with vascular complications of type 1 diabetes mellitus (T1DM). We examined the proton nuclear magnetic resonance (NMR)-assessed lipoprotein subclass profiles in subjects with T1DM compared with those of healthy subjects and assessed the potential relationship of these profiles with arterial stiffness. Methods: Eighty-four participants with T1DM of at least 10 years duration and no clinical cardiovascular disease (age: 35–65 years; 50% men) and 42 healthy participants were evaluated for: (1) clinical and anthropometric data (including classical cardiovascular risk factors), (2) insulin sensitivity by estimated glucose disposal rate, (3) microvascular complications, (4) NMR-assessed lipoprotein subclass profile, and (5) arterial stiffness (aortic pulse wave velocity). Results: Participants with T1DM had an apparently better conventional lipid profile than healthy participants, but with significant differences in NMR-assessed lipoprotein profiles such as higher triglyceride content of low-density lipoprotein (LDL) and high-density lipoprotein (HDL). In healthy participants, arterial stiffness was associated with NMR-based LDL subclasses. By contrast, in T1DM participants, arterial stiffness was independently associated mainly with NMR-based very-low-density lipoprotein (VLDL) subclasses: positively with total VLDL particles (and subclasses) and VLDL triglyceride content, and negatively with LDL and HDL particle sizes. These results were maintained after adjustments for classical cardiovascular risk factors. Conclusions: Subjects with T1DM, while having an apparently better conventional lipid profile than healthy controls, presented significant alterations in their NMR-assessed lipoprotein profile. The association between arterial stiffness and NMR-assessed lipoprotein profiles also differed in both groups. These results support a potential role of the identified differences in the residual cardiovascular risk in T1DM.

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Serum apolipoprotein B to apolipoprotein A‐I ratio predicts mortality in patients with heart failure

Li,

Xie,

Zeng

et al. 2023

ESC Heart Failure

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AimsApolipoproteins have been reported to be involved in many cardiovascular diseases. The aim of our study was to investigate the prognostic value of apolipoprotein B (ApoB) to apolipoprotein A‐I (ApoA‐I) ratio (ApoB/ApoA‐I) in patients with heart failure (HF).Methods and resultsWe randomly assigned 2400 HF patients into the training cohort (n = 1400) and the validation cohort (n = 1000). Using a receiver operating characteristic curve, we identified the optimal cut‐off value of the ApoB/ApoA‐I in the training cohort as 0.69, which was further validated in the validation cohort. A propensity score matching (PSM) analysis was conducted to eliminate the imbalance in the baseline characteristics of the high and low ApoB/ApoA‐I group. A total of 2242 HF patients were generated in the PSM cohort. We also validated our results with an independent cohort (n = 838). Univariate and multivariate analyses were conducted to explore the independent prognostic value of ApoB/ApoA‐I in the training cohort (n = 1400), the validation cohort (n = 1000), the PSM cohort (n = 2242), and the independent cohort (n = 838). Patients with high ApoB/ApoA‐I ratio had significantly poorer prognosis compared with those with low ApoB/ApoA‐I ratio in the training cohort, the validation cohort, the PSM cohort, and the independent cohort (P < 0.05). Multivariate analysis indicated that the ApoB/ApoA‐I was an independent prognostic factor for HF in the training cohort [hazard ratio (HR) = 1.637, 95% confidence interval (CI) = 1.201–2.231, P = 0.002], the validation cohort (HR = 1.54, 95% CI = 1.051–2.257, P = 0.027), the PSM cohort (HR = 1.645, 95% CI = 1.273–2.125, P < 0.001), and the independent cohort (HR = 1.987, 95% CI = 1.251–3.155, P = 0.004).ConclusionsSerum ApoB/ApoA‐I ratio is an independent predictor for the prognosis of HF patients.

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Lipoprotein composition in patients with type 1 diabetes mellitus: Impact of lipases and adipokines

Cited by 10 publications

References 42 publications

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study

Serum apolipoprotein B to apolipoprotein A‐I ratio predicts mortality in patients with heart failure

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