Lipoprotein Abnormalities in Chronic Kidney Disease and Renal Transplantation

Barbagallo, Carlo M.; Cefalù, Angelo Baldassare; Giammanco, Antonina; Noto, Davide; Caldarella, Rosalia; Ciaccio, Marcello; Averna, Maurizio; Nardi, Emilio

doi:10.3390/life11040315

Cited by 15 publications

(11 citation statements)

References 114 publications

(133 reference statements)

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“…The current study observed HDL levels to be low in CKD patients on hemodialysis, which is consistent with a study done by Ganta [18]. Our study is also strongly supported by the paper by Barbagallo et al [19]. A possible mechanism involved in low HDL levels is that uremic patients generally exhibit decreased levels of apolipoprotein AI and AII.…”

Section: Discussionsupporting

confidence: 93%

The Study of Pattern of Lipid Profile in Chronic Kidney Disease Patients on Conservative Management and Hemodialysis: A Comparative Study

Saini¹,

Vamne²,

Kumar³

et al. 2022

Cureus

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Background: Chronic kidney disease (CKD) causes irreversible damage to the renal tissue resulting in decreased kidney function. It is known more for its morbidity than for its mortality as the deranged kidney functioning affects almost every organ system of the body. Dyslipidemia is one of the most common complications of chronic renal failure (CRF) reflected even in the early stages of CRF and usually parallels the deterioration in renal function. As a consequence, dyslipidemia as a risk factor in CKD progression should be explored and documented more. The aim of the study was to compare the pattern of lipid profile in CKD patients on conservative management with that of CKD patients on hemodialysis.Materials and Methods: This is a cross-sectional observational study conducted in Lucknow, India, between January 2021 to May 2021 after considering inclusion and exclusion criteria. The lipid profile of 105 eligible patients was analyzed using an autoanalyzer. After generation of the proper template, data was entered in Microsoft Excel (Microsoft Corp., Redmond, Washington, United States) and analysis was done through SPSS for Windows, Version 16.0 (Released 2007, SPSS Inc., Chicago, United States).Results: There was a statistically significant decrease in high-density lipoprotein (HDL) and an increase in triglycerides (TG) and very-low-density lipoprotein (VLDL) levels in CKD patients on hemodialysis when compared with CKD patients on conservative management. As far as total cholesterol and low-density lipoprotein (LDL) levels are concerned, they were also significantly increased in CKD patients on hemodialysis than CKD patients on conservative management.Conclusions: Dyslipidemia progresses with the stage of CKD, so early monitoring of lipid profile in CKD patients may help in decreasing the progression of the disease and, hence, mortality in CKD patients.

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Section: Discussionsupporting

confidence: 93%

The Study of Pattern of Lipid Profile in Chronic Kidney Disease Patients on Conservative Management and Hemodialysis: A Comparative Study

Saini¹,

Vamne²,

Kumar³

et al. 2022

Cureus

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“…CKD is a known risk factor for cardiovascular disease, since elevated plasma levels of apoA-I containing lipoproteins may lead to the accumulation of atherogenic particles [63,64]. In our study, multiple apolipoproteins were dysregulated with respect to control samples.…”

Section: Discussionmentioning

confidence: 47%

“…Caught between pro-inflammatory signals, disrupted angiogenesis and tissue repair pathways, the kidney suffers from loss of function, which is apparent in lipid metabolism. CKD is a known risk factor for cardiovascular disease, since elevated plasma levels of apoA-I containing lipoproteins may lead to the accumulation of atherogenic particles [ 63 , 64 ]. In our study, multiple apolipoproteins were dysregulated with respect to control samples.…”

Section: Discussionmentioning

confidence: 99%

Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?

Grgurević

Novak²,

Salai³

et al. 2022

Biomedicines

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Chronic kidney disease (CKD) is the progressive loss of renal function. Although advances have been made in understanding the progression of CKD, key molecular events in complex pathophysiological mechanisms that mark each stage of renal failure remain largely unknown. Changes in plasma protein profiles in different disease stages are important for identification of early diagnostic markers and potential therapeutic targets. The goal of this study was to determine the molecular profile of each CKD stage (from 1 to 5), aiming to specifically point out markedly expressed or downregulated proteins. We performed a cross-sectional shotgun-proteomic study of pooled plasma across CKD stages and compared them to healthy controls. After sample pooling and heparin-column purification we analysed proteomes from healthy to CKD stage 1 through 5 participants’ plasma by liquid-chromatography/mass-spectrometry. We identified 453 proteins across all study groups. Our results indicate that key events, which may later affect the course of disease progression and the overall pathophysiological background, are most pronounced in CKD stage 2, with an emphasis on inflammation, lipoprotein metabolism, angiogenesis and tissue regeneration. We hypothesize that CKD stage 2 is the tipping point in disease progression and a suitable point in disease course for the development of therapeutic solutions.

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“…In this regard, CKD is characterized by an accumulation of VLDL (very-low-density lipoprotein) particles, a reduction of LDL particle size, and changes in the cholesterol and triglyceride content in LDL and HDL (high-density lipoproteins, which gain triglycerides and lose cholesterol). Notably, HDL in CKD patients turned out to lose its atheroprotective properties and even harm the vasculature [ 25 ].…”

Section: Cardiovascular Risk In Ckdmentioning

confidence: 99%

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

et al. 2022

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Atherosclerosis is the major cause of cardiovascular disease, leading to a high mortality rate worldwide. Several risk factors are known to favor atherogenesis, among which are high blood pressure, smoking, diabetes mellitus, and others. Chronic kidney disease is another serious health problem associated with significant health care costs, morbidity, and mortality. Chronic kidney disease shares several risk factors with atherosclerosis and cardiovascular diseases, such as hypertension and diabetes mellitus. Additional risk factors for cardiovascular disease development should be considered in patients with chronic kidney disease. Interestingly, patients suffering from chronic kidney disease are more prone to cardiovascular problems than the general population. Moreover, chronic kidney disease is characterized by an increased atherosclerotic burden from the very early stages. The purpose of this review was to summarize data on atherosclerosis in chronic kidney disease, highlighting the specific features of the disease combination.

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Lipoprotein Abnormalities in Chronic Kidney Disease and Renal Transplantation

Cited by 15 publications

References 114 publications

The Study of Pattern of Lipid Profile in Chronic Kidney Disease Patients on Conservative Management and Hemodialysis: A Comparative Study

The Study of Pattern of Lipid Profile in Chronic Kidney Disease Patients on Conservative Management and Hemodialysis: A Comparative Study

Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

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