Lipoprotein(a): relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study

Boomsma, Dorret I.; Kaptein, Allard; Kempen, H.J.M.; Leuven, J.A. Gevers; Princen, H.M.G.

doi:10.1016/0021-9150(93)90047-x

Cited by 76 publications

(43 citation statements)

References 45 publications

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“…This heritability estimate is very similar to the esti mates w e obtai ned previ ousl y i n thi s 13 and other Dutch sampl es 15 using a structural modelling approach to anal yse the data and al so cl osel y resembl es esti mates from other fami l y studi es. Si ze heterogenei ty of the Lp(a) pol ypepti de chai n w as associ ated w i th quanti tati ve Lp(a) pl asma l evel s. A major part (61% ) of the vari ance i n Lp(a) l evel s i n thi s sampl e coul d be attri buted to the di fference apo(a) i soforms.…”

Section: Discussionsupporting

confidence: 74%

The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations

Boomsma¹,

Knijff

Kaptein³

et al. 2000

Twin res.

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The effects of apol i popr otei n (a), apol i popr otei n-E, and apol i popr otei n-A 4 i sofor ms on quanti tati ve l i popr otei n(a) [Lp(a)] l evel s w er e assessed i n a sampl e of 142 Dutch fami l i es consi sti ng of tw o parents and their adolescent twin offspring. A total heritability of 95% w as esti mated for pl asma Lp(a) concentr ati ons. The l ar gest par t of thi s her i tability was due to the apo(a) l ocus w hi ch expl ai ned 61% of the total var i ance i n Lp(a) l evel s. The patter n of familial correlations for the r esi dual par t of the Lp(a) var i ance that coul d not be attr i buted to the apo(a) i sofor ms, suggested geneti c i nfl uences on the r esi dual var i ance. We addr essed the questi on w hether thi s r esi dual geneti c var i ance coul d be ascr i bed to the apoE or the apoA 4 l ocus. A si mul taneous anal ysi s of al l thr ee l oci show ed that both the apoE and the apoA 4 pol ymor phi sm di d not contr i bute si gni fi cantl y to Lp(a) var i ati on. Twin Research (2000) 3, 152-158.

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Section: Discussionsupporting

confidence: 74%

The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations

Boomsma¹,

Knijff

Kaptein³

et al. 2000

Twin res.

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“…This study is part of a larger project in which cardiovascular risk factors were studied in 160 adolescent twin pairs and their parents (Boomsma et al, 1998;Boomsma, Hennis, et al, 1993;Boomsma, Kaptein, et al, 1993;Ijzerman et al, 2000). Zygosity was determined as described in detail previously (Boomsma et al, 1998).…”

Section: Methodsmentioning

confidence: 99%

Intra-uterine and Genetic Influences on the Relationship Between Size at Birth and Height in Later Life: Analysis in Twins

et al. 2001

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Epidemiological studies have consistently shown a positive association between size at birth (i.e. birth weight or birth length) and height in children, adolescents and adults. To examine whether this association is explained by genetic or nongenetic (intra-uterine) factors, we investigated birth weight, birth length and height in 60 dizygotic and 68 monozygotic adolescent twin pairs still living with their parents. Birth weight of the twins was obtained from their mothers. Height was measured in a standardised way. The mean age was 17±1.7 years for the dizygotic twins and 16±1.8 years for the monozygotic twins. Both dizygotic and monozygotic twins with the lowest birth weight from each pair had a height that was lower compared to their co-twins with the highest birth weight (dizygotic twins: 172.2±7. .06], respectively). These associations were stronger in dizygotic than in monozygotic twins, but this difference was not statistically significant (for birth weight p = 0.4; and for birth length p = 0.6). However, genetic model fitting indicated that models incorporating a genetic source of the covariance gave a better description of the observed association of birth weight and length with height in later life than models not incorporating this genetic source. The results were similar for data on adult height after 12 years of follow-up in a subgroup of these twin pairs. These data suggest that the association between size at birth and height in later life is influenced by non-genetic intra-uterine and by genetic factors.

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“…These subjects, who were of European ancestry, were mostly selected because they came from larger participating families. An additional 337 twins from DZ pairs who had participated in earlier studies on cardiovascular risk factors (Boomsma et al, 1993;Snieder et al, 1997) were also genotyped.…”

Section: Sample and Questionnairesmentioning

confidence: 99%

Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression

et al. 2005

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A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, depression and neuroticism in a Dutch sample of 347 males and 448 females, and to DSM-IV major depression in a subsample of 210 males and 295 females. The association of the 124-bp allele to depression in females was not replicated, but there were significant associations (not significant after correction for multiple testing) with anxiety and anxious depression in males. However, the association occurred in the absence of evidence for linkage in this region on chromosome 2.

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Lipoprotein(a): relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study

Cited by 76 publications

References 45 publications

The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations

The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations

Intra-uterine and Genetic Influences on the Relationship Between Size at Birth and Height in Later Life: Analysis in Twins

Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression

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