Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes

Gilliland, Thomas; Liu, Yuxi; Mohebi, Reza; Miksenas, Hannah; Haidermota, Sara; Wong, Megan; Hu, Xingdi; Cristino, Joaquim; Browne, Auris; Plutzky, Jorge; Tsimikas, Sotirios; Januzzi, James L.; Natarajan, Pradeep

doi:10.1016/j.jacc.2023.02.050

Cited by 27 publications

(11 citation statements)

References 46 publications

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“…high-sensitivity C-Reactive Protein). 16 – 21 It may well be that dietary fats alone are an insufficient driver of Lp(a)'s atherogenic inducing mechanisms (including via elevated high sensitivity C-Reactive Protein or OxPL). Future studies may require evaluating additional macronutrients, more complex dietary patterns, and additional biomarkers to understand diet's association between Lp(a) and CV disease.…”

Section: Discussionmentioning

confidence: 99%

The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts

Patel,

Chennareddy,

Brandt

2024

JRSM Cardiovascular Disease

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Background Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death. Aim To understand if dietary fat modifies the association between Lp(a) and cardiovascular death. Methods We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death. Results The sample ( n = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, p = 0.001) and NHANES (1.31, p = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death. Conclusion There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.

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Section: Discussionmentioning

confidence: 99%

The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts

Patel,

Chennareddy,

Brandt

2024

JRSM Cardiovascular Disease

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“…The net result indicated that each apoB particle was proatherogenic [ 24 ]. Furthermore, phospholipids, one of the components of apoB particles, were strong proatherogenic factors associated with poor prognosis in an oxidized state [ 25 ]. Thus, compared to LDL-C, apoB particles integrated more proatherogenic risk factors in most cases.…”

Section: Discussionmentioning

confidence: 99%

“…Growing evidence illustrated the importance of apoB in the prevalence of CAD [ 25 , 27 ]; however, its predictive efficacy for CAD progression remained unclear. Richardson et al performed a genome-wide association study of LDL-C, apoB, and TG in the UK Biobank and validated the associations using a second database, CARDIoGRAMplusC4D.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B is associated with CT-angiographic progression beyond low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in patients with coronary artery disease

et al. 2023

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Background Accumulating evidence indicated that apolipoprotein B (apoB) was the principal lipid determinant of coronary artery disease (CAD). Nevertheless, the connection between apoB and angiographic progression of CAD remained undetermined. Methods Five hundred and forty-four CAD patients with twice coronary computed tomography angiography experiences were enrolled. The Gensini scoring system was used to assess angiographic progression. Incident angiographic progression was defined as an annual change rate of the Gensini score of > 1 point. The predictive efficacy of baseline apoB levels for angiographic progression was assessed using a receiver operating characteristic (ROC) curve. For comparative purposes, patients were categorized into three groups according to their baseline apoB tertiles. Furthermore, discordance analyses defined by the median were performed to assess the superiority of apoB over lipoprotein cholesterol in predicting angiographic progression of CAD. Results Angiographic progression was observed in 184 patients (33.8%) during a follow-up period of 2.2-year. The area under the ROC curve was 0.565 (0.522–0.607, P = 0.013). The incidence of angiographic progression was elevated with increasing apoB tertile after adjusting for confounding factors [odds ratio (OR) for the medium apoB tertile: 1.92, 95% confidence interval (CI): 1.15–3.19, P = 0.012; OR for the high apoB tertile: 2.05, 95%CI:1.17–3.60, P = 0.013]. Additionally, discordance analyses showed that the higher apoB group had a significantly higher risk of CAD progression in the fully adjusted model (all P < 0.05). Conclusions ApoB could be used as an accurate and comprehensive indicator of angiographic progression in patients with CAD.

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“…Studies have shown that Lp(a) as a risk factor for CAD is more pronounced in patients with high-density lipoprotein cholesterol (HDL-C) ≥35 mg/dL and non-obese patients [ 11 ]. Lp(a) and oxidized phospholipids apoB (OxPL-apoB) are associated with multiple coronary artery lesions, and Lp(a), OxPL-apoB, and OxPL-apo(a) are associated with cardiovascular events [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

A potentially underestimated predictor of coronary artery disease risk: The ApoB/ApoA1 ratio

Li,

Zhao,

Ding

et al. 2024

Heliyon

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Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes

Cited by 27 publications

References 46 publications

The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts

The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts

Apolipoprotein B is associated with CT-angiographic progression beyond low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in patients with coronary artery disease

A potentially underestimated predictor of coronary artery disease risk: The ApoB/ApoA1 ratio

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