Lipoprotein (a) is independently correlated with coronary artery calcification

Martin, Guillaume; Arnoldt, Thomas; Ziegler, Franz von; Ruemmler, Janine; Becker, Christoph; Wakili, Reza; D’Anastasi, Melvin; Schenzle, Jan; Leber, Alexander; Becker, Alexander

doi:10.1016/j.ejim.2012.08.014

Cited by 53 publications

(56 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, an accurate prediction of the degree of CAC is significant in clinical practice. In addition to the most commonly used imaging techniques at present, laboratory indexes, including lipoprotein(a), endothelin 1 and bone morphogenetic protein 2 levels, are also associated with calcification and may be utilized to assess the degree of CAC (19)(20)(21). To date, the association between serum calcium, phosphorus, CPP and CAC has been most widely discussed in previous studies (22,23); however, the conclusions are not consistent.…”

Section: Discussionmentioning

confidence: 92%

Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure

et al. 2016

Biomedical Reports

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the correlation between serum parathyroid hormone (PTH) levels and coronary artery calcification (CAC) in patients without renal failure, as well as to determine independent risk factors of CAC score (CACS). A total of 157 patients who underwent coronary computed tomography angiographic examination at the 101th Hospital of the People's Liberation Army between December 2013 and February 2015 were retrospectively evaluated. The correlation between PTH levels and CACS was determined using a Pearson correlation analysis. A receiver operating characteristic (ROC) curve was drawn to determine the best cutoff PTH level for prediction of CAC. The independent association between serum PTH levels and CAC was analyzed by using a logistic regression analysis model with the response variable Be binary class. The results revealed that PTH levels in patients in the CAC group were significantly higher than those of patients in the non-calcification group. PTH levels were positively correlated with CACS (r=0.288, P<0.001). The ROC curve suggested that a PTH level of ≥31.05 pg/ml was the best cut-off point for the prediction of CAC, with a sensitivity of 80.88%, specificity of 60.67% and an area under the curve of 0.761. After including predictive factors for CAC (gender, age, smoking status, diabetes, hypertension, hyperlipidemia, body mass index, glomerular filtration rate and calcium, phosphorus, calcium-phosphorus product, magnesium, PTH, total cholesterol, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol and C-reactive protein levels), the odds ratio of the serum PTH levels regarding the prediction of CAC was 1.050 (95% confidence interval, 1.027-1.074; P<0.001). In conclusion, the present study suggested that serum PTH levels are correlated with CAC in patients without renal failure and may thus be used as a reliable predictor of CAC.

show abstract

Section: Discussionmentioning

confidence: 92%

Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure

et al. 2016

Biomedical Reports

View full text Add to dashboard Cite

show abstract

“…55 Another study in a large cohort of European Caucasians found that although elevated Lp(a) correlated with increased CAC scores, Lp(a) was inferior to LDL-C or related measures, 56 the opposite of another study in a similar cohort. 53 Another study found that Lp(a) was only predictive of CAC in women with type 2 diabetes mellitus, but was not in women without diabetes or in men. 57 Clearly, additional studies are required to uncover the reasons for these discrepant findings and to determine the true relationship between elevated Lp(a) and subclinical atherosclerosis.…”

Section: Lipoprotein(a)mentioning

confidence: 98%

Lipoprotein(a)

Koschinsky

Boffa

2014

Endocrinology and Metabolism Clinics of North America

View full text Add to dashboard Cite

“…13 Also, despite an early finding suggesting that hyperlipidemic transgenic rabbits expressing the human apolipoprotein(a) gene have increased vascular calcification, studies that have sought to establish a link between lipoprotein(a) levels and coronary calcification in humans have yielded conflicting results. [14][15][16] Considerable evidence supports a role for lipoprotein(a) in the pathophysiology of AVS. First, lipoprotein(a) is a risk factor for cardiovascular disease (CVD), and AVS shares several common risk factors with CVD.…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis

Arsenault

Boekholdt

Dubé

et al. 2014

Circ Cardiovasc Genet

236

103

View full text Add to dashboard Cite

A ortic valve stenosis (AVS) is the most common valvular disease in the Western world. Its prevalence increases with age, reaching 2% to 3% of individuals aged >65 years. 1 The burden of AVS is high and is expected to double within the next 50 years.2 To date, the only effective treatment for AVS is aortic valve replacement, for which costs have been estimated to be up to $120 000. 3 The identification of risk factors for AVS is likely to help the medical and scientific communities develop novel and innovative treatment strategies. Up to now, male sex, smoking, hypertension, dyslipidemia, metabolic syndrome, and impaired glucose-insulin homeostasis have been associated with AVS incidence or progression. 4,5 Clinical Perspective on p 310Genetic association studies have sought to determine whether genetic variants are associated with AVS risk. 6 Recently, Thanassoulis et al 7 performed a large-scale meta-analysis of genome-wide scans for aortic valvular calcium in Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and identified rs10455872 at the LPA locus as a susceptibility single-nucleotide polymorphism (SNP) for aortic valvular calcium. This association was replicated in 2 population-based studies of AVS, namely the Copenhagen City Heart Study and the Malmö Diet and Cancer Study. However, the association between lipoprotein(a) levels and risk of AVS was not investigated in these studies. The evidence that patients with AVS could be characterized by high lipoprotein(a) levels is scarce. Glader et al 8 showedBackground-Although a previous study has suggested that a genetic variant in the LPA region was associated with the presence of aortic valve stenosis (AVS), no prospective study has suggested a role for lipoprotein(a) levels in the pathophysiology of AVS. Our objective was to determine whether lipoprotein(a) levels and a common genetic variant that is strongly associated with lipoprotein(a) levels are associated with an increased risk of developing AVS. Methods and Results-Serum lipoprotein(a) levels were measured in 17 553 participants of the European Prospective Investigation into Cancer (EPIC)-Norfolk study. Among these study participants, 118 developed AVS during a mean follow-up of 11.7 years. The rs10455872 genetic variant in LPA was genotyped in 14 735 study participants, who simultaneously had lipoprotein(a) level measurements, and in a replication study of 379 patients with echocardiographyconfirmed AVS and 404 controls. In EPIC-Norfolk, compared with participants in the bottom lipoprotein(a) tertile, those in the top lipoprotein(a) tertile had a higher risk of AVS (hazard ratio, 1.57; 95% confidence interval, 1.02-2.42) after adjusting for age, sex, and smoking. Compared with rs10455872 AA homozygotes, carriers of 1 or 2 G alleles were at increased risk of AVS (hazard ratio, 1.78; 95% confidence interval, 1.11-2.87, versus hazard ratio, 4.83; 95% confidence interval, 1.77-13.20, respectively). In the replication study, the genetic variant rs10455872 also showed a posit...

show abstract

Lipoprotein (a) is independently correlated with coronary artery calcification

Cited by 53 publications

References 27 publications

Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure

Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure

Lipoprotein(a)

Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis

Contact Info

Product

Resources

About