Lipoprotein(a) in patients with carotid atherosclerosis and ischemic cerebrovascular disorders

Jovicić, A; Ivanišević, Vesna; Ivanović, Ivan

doi:10.1016/0021-9150(93)90223-h

Cited by 50 publications

(19 citation statements)

References 22 publications

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“…Further evidence supporting this hypothesis was provided by previous investigations, in which Lp(a) concentration was shown to be an independent predictor of the presence of preclinical extracranial carotid atherosclerosis [24,25,26]. A graded relationship between the degree of carotid atherosclerosis and Lp(a) has also been demonstrated [25, 27].…”

Section: Discussionsupporting

confidence: 58%

Lp(a) Lipoprotein and Plasminogen Activity in Patients with Different Etiology of Ischemic Stroke

Petersen

Schmied²,

Zeller³

et al. 2006

Cerebrovasc Dis

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Background and Purpose: Lp(a) lipoprotein plays an important part in atherothrombogenesis and is considered an independent risk factor for coronary heart disease. However, its role in cerebrovascular disease remains unclear, in particular because of the heterogeneous nature of strokes. We investigated whether elevated Lp(a) is more frequent in ischemic stroke related to atherothrombosis than in other etiologies of stroke. Because of the close structural homology between Lp(a) and plasminogen, we also studied the role of plasminogen in different stroke subtypes and whether there is a dependency on Lp(a) plasma levels. Methods: Lp(a) levels and plasminogen activity were measured in 253 consecutive patients with acute ischemic stroke and in 63 controls (CS). Subtypes of stroke were established according to the TOAST criteria. Results: Median Lp(a) levels were found to be higher in the total cerebral infarction group and in patients with large artery atherosclerosis (LAA) when compared with CS (20.9 and 22.0 mg/dl, respectively, vs. 16.0 mg/dl; p < 0.05). In addition, elevated Lp(a) levels >30 mg/dl were more frequent among the LAA subgroup than among CS (39.4 vs. 11.1%; p < 0.001). Mean plasminogen activity was lower in the total cerebral infarction group (110.8 vs. 120.3%; p < 0.001) and in patients with cardioembolic stroke (109.8 vs. 120.3%; p < 0.05) when compared with CS. There was no correlation between Lp(a) levels and plasminogen activity. Conclusions: Our results support the hypothesis that elevated Lp(a) is a risk factor for ischemic stroke and especially for strokes caused by LAA. Low plasminogen activity may play a role in the pathogenesis of cerebrovascular disease, especially for the development of cardioembolic stroke.

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Section: Discussionsupporting

confidence: 58%

Lp(a) Lipoprotein and Plasminogen Activity in Patients with Different Etiology of Ischemic Stroke

Petersen

Schmied²,

Zeller³

et al. 2006

Cerebrovasc Dis

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“…6 -13 However, other studies have failed to confirm such an association. 14,36,37 Comparison of results from different studies is difficult because of methodological variations. For example, the method for defining cases differs among studies.…”

Section: Glader Et Al C Pneumoniae and Lp(a) For Cerebral Infarctionsmentioning

confidence: 99%

Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions

Glader

Stegmayr

Boman

et al. 1999

Stroke

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Background and Purpose-An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniaeIgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. Methods-This incident case-control study included 101 case subjects (cases) who had suffered ischemic cerebral infarctions and 201 matched control subjects (controls). The study population was nested within the Västerbotten Intervention Program or the WHO MONICA project. Plasma samples were measured for C pneumoniae-specific IgG and IgA antibodies and Lp(a). Results-A significantly higher mean Lp(a) level was found in female cases than in female controls. However, plasma Lp(a) was unable to predict ischemic cerebral infarctions in either women or men. The proportion of individuals with positive C pneumoniae-specific IgG or IgA titers did not differ between cases and controls. Antibody titers were unable to predict a future stroke. The proportion of individuals with a positive C pneumoniae IgG titer in combination with a high Lp(a) level did not differ significantly between cases and controls. Conclusions-These data suggest that there is no association between baseline plasma Lp(a) levels, presence of C pneumoniae antibodies, and future ischemic cerebral infarctions. Furthermore, no evidence of an interactive effect between high Lp(a) levels and C pneumoniae IgG titers was found. However, selection bias and a recent C pneumoniae epidemic may have influenced the results.

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“…Several studies have indicated that elevated lipoprotein(a) Lp(a) concentrations are a strong independent risk factor for premature ischaemic heart disease, 1,2 cerebrovascular and peripheral vascular disease, 3 and early occlusion of coronary artery bypass grafts and femoropopliteal vein grafts. 4 Genetic factors are the principal determinants of plasma Lp(a) concentrations 5,6 via differences in apolipoprotein(a) polymorphisms between individuals and races.…”

Section: Introductionmentioning

confidence: 99%

Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

1999

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BACKGROUND: Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The basis for this atherogenic property of Lp(a) and the factors that in¯uence its cross-population levels, however, remain poorly understood. OBJECTIVES: To investigate the relationship between serum Lp(a) and metabolic and anthropometric parameters in a healthy Kuwaiti population. DESIGN: Cross-sectional study. SUBJECTS: 177 (72 male, 105 female) randomly recruited healthy Kuwait Arabs aged 17 ± 60 y MEASUREMENTS: Metabolic parameters in serum: Lp(a), apo(a) phenotypes, lipids and lipoproteins, glucose and urate. Anthropometric parameters: body mass index (BMI) and waist:hip-ratio (WHR). RESULTS: The distribution of Lp(a) concentrations was positively skewed (median 153 mgal, range 0 ± 1086). Women had higher concentrations ± (194, 0 ± 1086) than men (117, 0 ± 779), P 0.069. Lp(a) and insulin concentrations were signi®cantly higher when the men and women were obese. In all subjects, there were signi®cant correlations between Lp(a) and BMI (r 0.23), total cholesterol (TC) (r 0. Multivariate analyses con®rmed BMI and low-density lipoprotein (LDL) as the signi®cant determinants of serum Lp(a).On apo (a) phenotyping, 114 (67%), 51 (30%) and 6 (4%) had single, double and null phenotypes respectively. The isoforms and their corresponding kringle IV repeat numbers were: F (14 repeats in 3%, mean Lp(a) 497 mgal); S1 (19 repeats in 14%, mean 245 mgal); S2 (23 repeats in 16%, mean 264 mgal); S3 (27 repeats in 35%, mean 236 mgal); and S4 (35 repeats in 28%, mean 235 mgal). DISCUSSION AND CONCLUSION: The results from the Kuwaiti population studied suggest that: (1) serum Lp(a) concentrations and distribution are similar to the pattern in Caucasians and Asians but not African ± Americans or Africans; (2) serum Lp(a) is variably in¯uenced by BMI and LDL ± the impact of either factor differs between the sexes; (3) there is a high frequency of the single-banded phenotype; (4) contrary to reports in some Caucasian and Asian populations, there is no simple relationship between kringle IV repeat numbers and plasma Lp(a) concentrations.

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Lipoprotein(a) in patients with carotid atherosclerosis and ischemic cerebrovascular disorders

Cited by 50 publications

References 22 publications

Lp(a) Lipoprotein and Plasminogen Activity in Patients with Different Etiology of Ischemic Stroke

Lp(a) Lipoprotein and Plasminogen Activity in Patients with Different Etiology of Ischemic Stroke

Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions

Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

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