LIPOPROTEIN(a) IN ALCOHOL-DEPENDENT MALE PATIENTS DURING A SIX-MONTH ABSTINENCE PERIOD

Budzyński, Jacek; Kłopocka, Maria; Świątkowski, Maciej; Pulkowski, Grzegorz; Ziółkowski, Marcin

doi:10.1093/alcalc/agg045

Cited by 11 publications

(6 citation statements)

References 35 publications

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“…Lp(a) decreased after the regular daily ingestion of red wine with 30 g alcohol [ 44 ]. In 2 other studies Lp(a) increased after alcohol withdrawal [ 45 , 46 ]. In a postmenopausal women, no effect of two alcoholic drinks a day on Lp(a) was observed [ 47 ].…”

Section: Discussionmentioning

confidence: 96%

A daily glass of red wine associated with lifestyle changes independentlyimproves blood lipids in patients with carotid arteriosclerosis: results from arandomized controlled trial

Droste

Iliescu

Vaillant

et al. 2013

Nutr J

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A daily glass of red wine associated with lifestyle changes independently improves blood lipids in patients with carotid arteriosclerosis: results from a randomized controlled trial AbstractBackground: Physical exercise and a Mediterranean diet improve serum lipid profile. The present work studied whether red wine has an effect on top of a lipid-lowering lifestyle in patients with carotid atherosclerosis.Methods: A prospective randomised unblinded trial was performed from 2009 to 2011 in 108 patients with carotid atherosclerosis, 65% of whom were already on statin therapy with a low mean LDL of 104.9 mg/dl. Half of them were advised to follow a modified Mediterranean diet and to perform moderate physical exercise during 30 min/ day (lifestyle changes) for 20 weeks. Within these two groups half of the patients were randomised either to avoid any alcohol or to drink 100 ml of red wine (women) or 200 ml of red wine (men) daily. Results: LDL was significantly lowered by 7% in the lifestyle-changes group compared to the no-lifestyle-changes group (p = 0.0296) after 20 weeks. Lifestyle changes lowered the LDL/HDL ratio after 20 weeks by 8% (p = 0.0242) and red wine independently by 13% (p = 0.0049). The effect on LDL/HDL ratio after 20 weeks was, however, more pronounced in the non-LC group. Total cholesterol (−6%; p = 0.0238) and triglycerides (−13%; p = 0.0361) were lowered significantly by lifestyle changes after 20 weeks compared to the no-lifestyle-changes group. Lipoprotein (a) was not significantly affected by any intervention. The given results are per ITT analysis. Conclusions: Lifestyle changes including a modified Mediterranean diet and physical exercise as well as a glass of red wine daily improve independently the LDL/HDL ratio in patients with carotid arteriosclerosis even though the vast majority of them was already on statin therapy. Trial registration: http://www.clinicaltrials.gov, NCT01146132

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Section: Discussionmentioning

confidence: 96%

A daily glass of red wine associated with lifestyle changes independentlyimproves blood lipids in patients with carotid arteriosclerosis: results from arandomized controlled trial

Droste

Iliescu

Vaillant

et al. 2013

Nutr J

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“…Glutathione is the most abundant endogenous antioxidant, considered as a non-enzymatic and direct extractor of ROS. The decrease in hepatic and renal nitrite levels could be attested the endothelial dysfunction caused by chronic ingestion of ethanol [31,32] . In addition, the increase of the level of MDA also confirm hepatic and renal tissue damages and alteration of the antioxidant defenses to neutralize the ROS [33] .…”

Section: Discussionmentioning

confidence: 99%

Protective potential of aqueous extract from <em>Dichrocephala integrifolia </em>(Linn. f.) O. Kuntze (Asteraceae) on blood and biochemical constituents in ethanol-induced hepato-nephrotoxicity in rats

Mbatchou¹,

Florence²,

Hubert³

et al. 2022

J. Med. Plants Stud.

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Dichrocephala integrifola is a plant used empirically to manage hepatic affections. This study evaluates the preventive effects of the aqueous leave extract of Dichrocephala integrifolia on the blood and biochemical parameters in ethanol-induced hepato-nephrotoxicity in rats. To achieve this, the animals received different treatments (p.o): a normal control group and a negative group receiving respectively distilled water (10 mL/kg) and ethanol 40° (4 g/kg) with distilled water simultaneously; 3 other groups receiving the two doses of the plant extract or Simepar (100 mg/kg) and ethanol simultaneously. At the end of the experimental period, haematological and biochemical analyses were performed. The ingestion of ethanol provoked a decrease (at least p< 0.01) in the liver relative weight. The concentration of RBC, HGB, HCT; MCV; PLT; WBC; LYMP; NEUT; MONO dropped while the levels of WBC raised. Ethanol administration caused an (p< 0.001) increase in malondialdehyde even SOD and catalase activities whereas a decreased in nitrites and GSH was noticed. Transaminase levels, ALP, bilirubin and lipid profile were significantly altered associated with a micro-architectural disorganization materialized by hepatic cytolysis, diffuse infiltration of periportal inflammatory cells and dilation of sinusoids capillaries as well as an architectural disorganization of the kidney parenchyma with leukocyte infiltration. The extract protected the alteration of these parameters. It prevented the amplification of alterations induced by ethanol on hepatic and renal micro-architecture tissue whatever the doses. Data suggest the antioxidant and hepatoprotective activities of the extract, attesting the use of this extract in the treatment of liver affection in traditional medicine.

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“…The potential benefits of reducing the concentration of triglycerides are controversial 3 ) . Some authors are of the opinion that the level of triglycerides after a meal is a better determinant of cardiovascular risk 38 ) . In the present study triglycerides were determined on an empty stomach, and their level after 10 weeks of practising Nordic Walking was 27 mg/dl (10% on average).…”

Section: Discussionmentioning

confidence: 99%

The influence of a ten-week Nordic walking training-rehabilitation program on the level of lipids in blood in overweight and obese postmenopausal women

et al. 2015

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[Purpose] The aim of this study was to evaluate the effect of a ten-week Nordic Walking (NW) rehabilitation program on chosen anthropometric parameters and the level of basic lipids in overweight and obese postmenopausal women’s blood. [Subjects and Methods] The subjects were 32 women aged 50–68 (average: 59.7 ± 5.9 years). The study was carried out following a non-randomized model and entailed NW rehabilitation 5 times a week, which lasted for 10 weeks, as well as a low-calorie 1,500 kcal diet. The therapeutic results of the study were measured through changes in anthropometric and biochemical parameters. The results were subjected to a statistical analysis. [Results] After 10 weeks of NW rehabilitation it was observed that participants lost weight and their body mass index dropped. Additionally, whereas levels of total cholesterol, LDL and triglycerides dropped, and the level of HDL increased. [Conclusion] Rehabilitation carried out according to the NW model resulted in statistically significant changes in basic lipids in blood which, considerably increased the percentage of persons who achieved the recommended level of blood lipids. Obese persons were characterised by a smaller rehabilitation weight loss. More intense workouts and cooperation with a dietician are required.

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LIPOPROTEIN(a) IN ALCOHOL-DEPENDENT MALE PATIENTS DURING A SIX-MONTH ABSTINENCE PERIOD

Cited by 11 publications

References 35 publications

A daily glass of red wine associated with lifestyle changes independentlyimproves blood lipids in patients with carotid arteriosclerosis: results from arandomized controlled trial

A daily glass of red wine associated with lifestyle changes independentlyimproves blood lipids in patients with carotid arteriosclerosis: results from arandomized controlled trial

Protective potential of aqueous extract from <em>Dichrocephala integrifolia </em>(Linn. f.) O. Kuntze (Asteraceae) on blood and biochemical constituents in ethanol-induced hepato-nephrotoxicity in rats

The influence of a ten-week Nordic walking training-rehabilitation program on the level of lipids in blood in overweight and obese postmenopausal women

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