Lipoprotein(a), Ferritin, and Albumin in Acute Phase Reaction Predicts Severity and Mortality of Acute Ischemic Stroke in North Indian Patients

Chakraborty, Baidarbhi; Vishnoi, Gaurav; Goswami, Binita; Gowda, Srinivas H.; Chowdhury, Debashish; Agarwal, Sarita

doi:10.1016/j.jstrokecerebrovasdis.2012.10.013

Cited by 34 publications

(34 citation statements)

References 49 publications

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“…Previous authors have [24][25][26]. Low serum albumin levels have also been used as predictors of poor outcome in other diseases as well [27][28][29]. Hypoalbuminaemia is an indicator of protein energy depletion and a marker of poor nutritional status; furthermore, it increases the risk of postoperative complications including poor wound healing, wound infections, pneumonia, and sepsis.…”

Section: Biochemical Parametersmentioning

confidence: 99%

Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients

et al. 2015

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Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors for one-year mortality in patients with hip fractures. A total of 236 consecutive patients (59 males) with hip fractures were followed over a one-year period. Patient age, gender, type of fracture, type of treatment, time from admission to surgery, type of anesthesia, body mass index, and electrocardiograms were recorded. Complete blood counts, serum electrolytes, urea, creatinine, d-dimers, calcium, phosphate, osteocalcin, and beta-isomerised C-terminal telopeptide of collagen type I (β-CTX) were measured at admission and estimated glomerular filtration rate (eGFR) was calculated. Multivariate Cox regression models were used to analyze the association of these parameters with survival. One-year mortality rate was 28.4%. Age was independently associated with mortality (HR 1.117, 95% CI 1.062-1.174, P < 0.001). In a multivariable model, mortality was increased in patients with higher β-CTX (HR 4.63 95% CI 1.87-11.45, P = 0.001) and lower eGFR (HR 0.972, 95% CI 0.956-0.987, P < 0.001). Patients younger than 84 years, with eGFR < 55.4 ml/min had ten times higher mortality rates (3.2 vs. 24.5%, HR 9.73, 95% CI 2.06-45.93) as well as those with β-CTX > 0.276 g/L (3.5 vs. 25.7%, HR 9.5, 95% CI 2.11-42.76). Advanced age, high β-CTX levels, and impaired renal function are independent risk factors of mortality in patients with hip fractures.

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Section: Biochemical Parametersmentioning

confidence: 99%

Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients

et al. 2015

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“…Oxidative stress mediated cellular damage, injury [21] and modification increases the inhibitory effect of Lp(a) on plasminogen binding to cell surfaces, which could attenuate fibrinolytic activity by reduced the activation of plasminogen [22]. Inflammation exacerbates the response to tissue or endothelial cells injury and acts as a prognostic marker of the current ischemic event, to act as the acute phase reaction [23]. Elevated Lp(a) concentration seems to be genetically modulated, some metabolic abnormalities might influence its synthesis or catabolism, such as the acute-phase response, endocrine disorders, diabetes, liver and renal failure [24].…”

Section: Discussionmentioning

confidence: 99%

Association of Elevated Serum Lipoprotein(a), Inflammation, Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients

2016

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Hypertension is the most common cardiovascular risk factor. Lipoprotein(a) [Lp(a)], inflammation, oxidative stress and chronic kidney disease (CKD) exacerbate the response to tissue injury and acts as markers of the vascular disease, especially in glomerulosclerosis. We compared the clinical characteristics of 138 non-diabetes hypertensive women (ndHT) patients with 417 non-diabetes normotensive subjects and tested the association of hypertension with Lp(a), inflammation, CKD and oxidative stress by using multiple logistic regression. BP, BMI, waist circumference, creatinine, Lp(a), inflammation and malondialdehyde levels were significantly higher and CKD state in the ndHT patients (p \ 0.05). Multiple logistic regression showed hypertension associated with increased Lp(a), inflammation, ORs and 95 % CIs were 2.52 (1.33, 4.80), 2.75 (1.44, 5.27) after adjusting for their covariates. Elevated serum Lp(a) and inflammation levels concomitants with increased oxidative stress and CKD were the major risk factors associated with hypertension and implications for the increased risk of HT and vascular disease.

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“…12 According to the Chkaraborty and et al study rate of albumin has significant relation with increasing severity of disease and long bad prognosis of diseases. 13 Yuko and et al showed that higher doses of albumin therapy may have neuroprotective effects on ischemic stroke. 14 Various study showed that Neuroprotective effects of Albumin significantly decrease if more than 4-5 hours after beginning stroke symptoms is past.…”

Section: Discussionmentioning

confidence: 99%

Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke

Abbasi

Fattahzadeh-Ardalani

Safarnejad

et al. 2016

Int J Basic Clin Pharmacol

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Lipoprotein(a), Ferritin, and Albumin in Acute Phase Reaction Predicts Severity and Mortality of Acute Ischemic Stroke in North Indian Patients

Cited by 34 publications

References 49 publications

Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients

Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients

Association of Elevated Serum Lipoprotein(a), Inflammation, Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients

Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke

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