Lipoprotein (a) does not participate in the early acute phase response to training or extreme physical activity and is unlikely to enhance any associated immediate cardiovascular risk

Byrne, D.J.; Jagroop, IA; Montgomery, Hugh; Thomas, Michael A.; Mikhailidis, Dimitri P.; Milton, Nathaniel G.N.; Winder, A F

doi:10.1136/jcp.55.4.280

Cited by 21 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several population and cross-sectional studies showed a lack of association between serum Lp(a) levels and regular moderate physical activity or moderate exercise training. [20][21][22][23][24]29 The few studies that found a beneficial effect of exercise on Lp(a) were either confounded by ethnical issues 25 or included only men. 26 Therefore, it appears likely that the changes in Lp(a) levels observed in our study were caused by the dietary intervention rather than by the increased physical activity.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Similarly, the effect of physical exercise on Lp(a) levels is not fully understood, with several contradicting reports. [20][21][22][23][24][25][26][27][28][29] Only few studies were performed in children. 27,28 In this study, we therefore tested the possibility of lowering Lp(a) levels by a weight reduction program during a 3-week dietary camp for obese children.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

et al. 2009

View full text Add to dashboard Cite

Background: Lipoprotein(a) [Lp(a)] is considered an independent risk factor for cardiovascular disease. Its concentration is mainly determined by the kringle-IV repeat copy number variation (CNV) at the apolipoprotein(a) [apo(a)] locus. Objective: We aimed to investigate the immediate effect of weight reduction on plasma Lp(a) levels and its dependency on the apo(a) CNV in obese children. Design: We performed a prospective longitudinal intervention study of a low-fat hypocaloric diet conducted in a 3-week dietary camp for obese children. In all, 140 obese participants (54 boys and 86 girls) with a mean age of 12.5 ± 1.6 years and a mean relative body mass index (BMI) before treatment of 165.6±24.7% were included. Body weight and plasma levels of Lp(a), lipids, apolipoproteins A-I and B, insulin, and C-reactive protein were determined before the onset and after the end of the intervention. In addition, the number of apo(a) kringle-IV repeats were determined using sodium dodecyl sulfate agarose gel electrophoresis. Results: The mean loss of body weight was 5.0 ± 1.3 kg (À6.6%), resulting in a mean decrease of the relative BMI of 6.6%. Blood chemistry revealed significant changes in all parameters, especially in Lp(a), with a decrease from 24.4 ± 30.6 to 17.9 ± 22.6 mg per 100 ml or À19% (Po0.001). The decrease of Lp(a) levels was higher in the group with low compared with high molecular weight apo(a) phenotypes (À23.9 vs À16.6%). Conclusions: Weight reduction in obese children is associated with significant changes in Lp(a) levels, especially in subjects with high pre-treatment Lp(a) concentrations. This effect is markedly influenced by the molecular phenotype at the copy-number variable apo(a) locus.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In 6 studies [18][19][20][21][22][23] there was a decrease in the concentration of CRP, and in one study only 24 there was an increased after the intervention with PA. In addition to PCR, there was a decrease in γ-fibrinogen, retinol carrier protein (RBP4), IL-6 e PAI-1.…”

Section: Resultsmentioning

confidence: 99%

“…Intense and moderate exercises were also used 18,19,24,[30][31][32][33] planned exercises and sports games 29 and controlled exercises in exercise bike 31 besides sedentary behavior evaluation 20 . Longitudinal studies also assessed cardiorespiratory fitness by different methods: ergospirometry test 29 , 20 m shutle-run test 9 and cardiorespiratory test on exercise bike 32,33 .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Physical Activity on Cardiometabolic Markers in Adolescents: Systematic Review

Miranda

Amorim

Oliveira

et al. 2016

Rev Bras Med Esporte

View full text Add to dashboard Cite

The accumulation of body fat is a major risk factor for cardiometabolic diseases. Obesity can be considered a chronic systemic inflammatory disease in adults and younger people. The control of subclinical inflammation process through the practice of physical activity (PA) can mitigate the effects of risk factors that trigger atherosclerosis that worsens with advancing age. The objective of this study was to conduct a systematic review of the influence of physical activity and/or exercise on cardiometabolic markers and othrer risk factors of cardiovascular disease in adolescents. A systematic review was conducted in electronic databases Scopus, Pubmed, Conchrane Collection and SciELO. The terms used in the search were "cardiovascular diseases AND inflammation AND adolescents AND physical activity OR exercise". A total of 24 original articles were evaluated, being 14 longitudinal and 10 cross-sectional studies. Overall, 16 articles (66.66%) showed that PA, exercise and/or sedentary behavior may have influenced or have been related to the concentration of cardiometabolic markers. All studies that examined lifestyle changes showed reduction of cardiometabolic markers. Some limitations were observed: reduced samples, lack of dietary prescription, evaluation and control of volume and intensity of exercise. Most of the studies analyzed showed that the physical activity could influence and decrease the concentrations of cardiometabolic markers in adolescents. However, studies with representative sample size and precise control in assessing the level of physical activity and/or exercise are required to determine accurately the changes that the more active lifestyle can bring on inflammatory process, as well as other risk factors for cardiometabolic diseases in adolescents.

show abstract

Lipoprotein(a)

Sorrentino¹

2011

Hyperlipidemia in Primary Care

View full text Add to dashboard Cite

Lipoprotein (a) does not participate in the early acute phase response to training or extreme physical activity and is unlikely to enhance any associated immediate cardiovascular risk

Cited by 21 publications

References 38 publications

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

Effect of Physical Activity on Cardiometabolic Markers in Adolescents: Systematic Review

Lipoprotein(a)

Contact Info

Product

Resources

About