Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients

Gazzaruso, Carmine; Bruno, Raffaele; Pujia, Arturo; Amici, Emanuela; Fratino, Pietro; Solerte, S. B.; Garzaniti, Adriana

doi:10.1016/j.ijcard.2005.05.022

Cited by 24 publications

(15 citation statements)

References 27 publications

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“…There has been some controversy concerning the association between Lp(a) and CAD in patients with diabetes. Several cross‐sectional studies reported an association between Lp(a) and CAD in diabetic patients [34–38], but some did not [39–41]. In our investigation, we found that Lp(a) at baseline was independently associated with the presence of significant coronary stenoses among nondiabetic patients, but not among patients with T2DM.…”

Section: Discussioncontrasting

confidence: 41%

Lipoprotein(a), type 2 diabetes and vascular risk in coronary patients

Saely

Koch

Schmid

et al. 2006

Eur J Clin Investigation

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Section: Discussioncontrasting

confidence: 41%

Lipoprotein(a), type 2 diabetes and vascular risk in coronary patients

Saely

Koch

Schmid

et al. 2006

Eur J Clin Investigation

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“…Several studies showed that Lp(a) levels were associated with CAD extent and progressions in the general population [28,29,30,31], and the group of type II diabetic patients [32, 33]. In addition, some studies showed that Lp(a) levels and apo(a) polymorphism are associated with CAD severity [32, 34].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some studies showed that Lp(a) levels and apo(a) polymorphism are associated with CAD severity [32, 34]. Although the mechanism of Lp(a) in the progression of CAD was not clearly defined, the possible mechanism of correlation between elevated levels of Lp(a) and rapid progression of CAD could be explained with its content of OxPL, may be proatherogenic, particularly since it has enhanced binding to the extracellular matrix of the artery wall [25].…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease

Moon

Kwon

et al. 2007

Cardiology

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Background: The pathophysiological role and metabolic pathway of Lp(a) have not been clearly defined. An association between Lp(a) and oxidative low-density lipoprotein (LDL) were recently reported. And small dense LDL (sd-LDL) were associated with circulating malondialdehyde-modified LDL. We investigated the relationships between serum Lp(a) level and LDL particle size in coronary artery disease (CAD) patients. Further, we investigated the relationships of sd-LDL and Lp(a) with the extent and severity of CAD. Methods: A total of 490 patients (mean: 60.5 ± 11.5 years old) who underwent coronary angiography to evaluate chest pain were investigated. Patients were classified into two groups, a CAD group (n = 256), who had significant stenosis observed by coronary angiogram, and a control group (n = 234), who had normal, or minimal coronary arteries. CAD severity was measured by Gensini scores. The distribution of the LDL subfraction was analyzed using a Quantimetrix Lipoprint LDL System. Results: The serum Lp(a) concentration was correlated with the fraction of sd-LDL (r = 0.193, p < 0.001) and mean LDL size (r = 0.160, p = 0.003). The Lp(a) level and mean LDL particle size were significantly correlated with a high Gensini score. LDL particle size in the CAD group was smaller than in the control group (26.74 ± 0.64 vs. 26.43 ± 0.93 nm, p < 0.001). The Gensini score was significantly higher in small LDL with high Lp(a) level groups. Conclusion: The positive correlation of the level of Lp(a) and sd-LDL fraction were demonstrated. The mechanism of this association is not clearly defined; we can suggest that it may stem from the individual atherogenic condition that linked to increased oxidative stress. Both increased Lp(a) and sd-LDL fraction were correlated with the severity of CAD.

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“…7 However, although Lp(a), used as a unique cardiovascular risk factor, has been widely, intensively studied for many years, particularly in recent years, whether the level of Lp(a) is an independent risk factor for CVD remains controversial till now. [8][9][10][11][12][13] Several studies indicated that Lp(a) might initiate atherosclerosis 14,15 and possibly promote thrombosis at very high levels, 16 while other data did not support the notion that Lp(a) was an independent predictor for CVD risk. 17 At the same time, few studies have analysed the relationship between serum Lp(a) levels and the severity of coronary artery disease (CAD), in particular using the well-recognized quantitative coronary scores in a large sample size.…”

Section: Introductionmentioning

confidence: 99%

Role of lipoprotein(a) in predicting the severity of new on-set coronary artery disease in type 2 diabetics: A Gensini score evaluation

Chen

Zhang

et al. 2015

Diabetes and Vascular Disease Research

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The objective of the study was to investigate the usefulness of serum lipoprotein(a) level in predicting the severity of new on-set coronary artery disease in type 2 diabetics. A total of 1254 new on-set, consecutive coronary artery disease patients were classified into two groups: diabetes group (n = 380) and non-diabetes group (n = 874). The relationship between serum lipoprotein(a) levels and the severity of coronary artery disease assessed by Gensini score was analysed. Data showed that the diabetes group had higher serum triglyceride and high sensitivity C-reactive protein levels but lower high-density lipoprotein cholesterol levels (all p < 0.05). The multivariate logistic regression analysis suggested that lipoprotein(a) was an independent predictor for high Gensini score (odds ratio = 1.82, 95% confidence interval: 1.10-3.12, p = 0.029) after adjusting for traditional cardiovascular risk factors. Additionally, lipoprotein(a) levels were positively correlated with Gensini score (rho = 0.15, p = 0.014) and significantly elevated according to the tertiles of Gensini score (p = 0.008) in diabetics. However, no such results were observed in non-diabetics. Our data indicate that lipoprotein(a) is an independent predictor for the severity of new on-set coronary artery disease patients accompanied by type 2 diabetes, suggesting that these patients may benefit from lipoprotein(a) management in clinical assessment.

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Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients

Cited by 24 publications

References 27 publications

Lipoprotein(a), type 2 diabetes and vascular risk in coronary patients

Lipoprotein(a), type 2 diabetes and vascular risk in coronary patients

Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease

Role of lipoprotein(a) in predicting the severity of new on-set coronary artery disease in type 2 diabetics: A Gensini score evaluation

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