Lipoprotein(a) and Cardiovascular Diseases　― Revisited ―

Jang, Albert Youngwoo; Han, Seung Hwan; Sohn, Il Suk; Oh, Pyung Chun; Koh, Kwang Kon

doi:10.1253/circj.cj-20-0051

Cited by 49 publications

(30 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In logistic regression analysis, LDL-C, TG and other indexes have weak correlation with AS and myocardial infarction, which may be related to patients taking lipid-lowering drugs. At present, a variety of drugs have been proved to reduce LP (a) level [31,32]…”

Section: Discussionmentioning

confidence: 99%

Lp (a): An Independent Predictive Marker In Diseases

Liu

Xiang

2022

Preprint

View full text Add to dashboard Cite

objective To investigate the serum lipoprotein (a)(Lp (a)) level and analyze the correlation between Lp (a) and sex, age, smoking, drinking, different diseases and other blood lipid indexes.Methods 7432 inpatients in Second Xiangya Hospital from 2013 to 2020 were selected, 8 items of medical records were collected, and statistic were analyzed by SSPS 24.0 software.Results The differences of LP (a) in different age groups and smoking or not groups were statistically significant (P < 0.05). There were noteworthy differences in Lp (a) between chronic kidney disease (CKD) group, atherosclerosis (AS) group and AS patients with other diseases compared with the control group. Significant differences were seen in myocardial infarction (MI) and stroke groups, but not for the diabetes mellitus (DM) group and the high blood pressure group with the control group. The correlation coefficients of LP (a) with apolipoprotein B-100 (apoB), cholesterol (CHO), high-density lipoprotein (HDL-C) and lowdensity lipoprotein (LDL-C) were 0.179, 0.132, 0.143 and 0.143, respectively. Linear regression analysis showed that LP (a) level was positively correlated with age, smoking or not, AS, MI , CKD,β=0.101, 0.042, 0.086, 0.119, 0.015, respectively.Conclusion LP (a) is related to apo-B, CHO, HDL-C and LDL-C t, AS, MI and CKD.

show abstract

Section: Discussionmentioning

confidence: 99%

Lp (a): An Independent Predictive Marker In Diseases

Liu

Xiang

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Many studies have reported that elevated plasma Lp (a) is an independent risk factor for CAD, which mainly participates in the pathophysiological process of CAD via prothrombotic/anti-brinolytic effects and promoting the deposition of cholesterol in the vascular intima [33][34][35]. On an equimolar basis, Lp (a) is more likely to cause atherosclerosis than LDL because it not only contains all proatherogenic components of LDL-C but also those of Apo (a) [13].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Predictive Values of Different Lipid Parameters Combined with Carotid Intima-Media Thickness in Coronary Artery Disease

Dong

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Blood lipids disorder and atherosclerosis are closely related to coronary artery disease (CAD). This study aims to compare different blood lipid parameters combined with carotid intima-media thickness (cIMT) in predicting CAD.Methods: This was a retrospective study including patients who underwent coronary angiography for highly suspected CAD. Blood samples were taken for lipid profile analysis and cIMT was evaluated by carotid ultrasound. Logistic analysis was used to establish different models of different lipid parameters in predicting CAD. The area under the receiver operating characteristic curve (AUC) was used to examine the predictive value. The optimal lipid parameter was also used to explore the relationship with multi-vessel CAD. Results: Patients were classified into two groups based on whether CAD existed. There was no difference in low-density lipoprotein cholesterol (LDL-C) between the two groups. Compared with non-CAD patients, the CAD group had higher lipoprotein (a) (Lp (a)), apolipoprotein B/apolipoprotein A, total cholesterol/high-density lipoprotein cholesterol (HDL-C), triglyceride/HDL-C and LDL-C/HDL-C. According to the AUCs, Lp (a) combined with cIMT (AUC: 0.713, p < 0.001) had the best performance in predicting CAD compared to other lipid parameters. High levels of Lp (a) was also associated with multi-vessel CAD (odds ratio: 1.41, 95% confidence interval: 1.02–1.95, P = 0.036).Conclusion: For patients with highly suspected CAD, Lp (a) better improved the predictive value of CAD rather than most of blood lipid indices, especially in the absence of high levels of LDL-C. Lp (a) also can be used to predict the multi-vessel CAD.

show abstract

“…Lp(a) thus simultaneously inherits the atherogenic properties of apoB within LDL-C, and the thrombotic and proinflammatory characteristics of apo(a). 48 Because Lp(a) is not an enzyme or a receptor, small molecules are not able to inactivate its function. Also, Lp(a)-neutralizing mAbs would be needed in massive amounts because Lp(a) exists in high concentrations.…”

Section: Atherothrombotic and Proinflammatorymentioning

confidence: 99%