Lipoprotein(a) and calcific aortic valve disease: current evidence and future directions
Nick S.R. Lan,
Zahid Khan,
Gerald F. Watts
Abstract:Purpose of review
Calcific aortic valve disease (CAVD), the most common cause of aortic stenosis (AS), is characterized by slowly progressive fibrocalcific remodelling of the valve cusps. Once symptomatic, severe AS is associated with poor survival unless surgical or transcatheter valve replacement is performed. Unfortunately, no pharmacological interventions have been demonstrated to alter the natural history of CAVD. Lipoprotein(a) [Lp(a)], a low-density lipoprotein-like particle, has been implic… Show more
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