Lipoprotein [a]

Ende, A. van den; Hoek, Ytje Y. van der; Kastelein, J.J.P.; Koschinsky, Marlys L.; Labeur, C.; Rosseneu, M.

doi:10.1016/s0065-2423(08)60426-6

Cited by 13 publications

(23 citation statements)

References 342 publications

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“…26 The distribution was also positively skewed, similar to the distributions in Caucasians, Chinese and some Hispanic populations. 26 These levels are lower than reported values in native Africans and African Americans, in whom the distribution is also different, being more bell-shaped with a tendency to higher values. 18,25,28,31 There was, however, a tendency towards higher Lp(a) values in the women we studied (P 0.069), as in Koreans 20 and Nigerians.…”

Section: Lp(a) and Anthropometric Demographic And Biochemical Paramesupporting

confidence: 52%

“…26 An inverse correlation of the serum Lp(a) concentrations with the molecular weight of the apo(a) isoform and with the size of the corresponding apo(a) gene 17,26 has indeed been demonstrated in Caucasian subjects in whom it has also been estimated that between 41 and 90% of the serum concentration is determined by the apo(a) polymorphism. 25 ± 27 This correlation, and the latter quoted percentage, is inconsistent in all populations, being as low as 19% in Sudanese blacks, 26 and it has not been described, to our knowledge, in an Arab population. BMI body mass index; WHR waist:hip ratio; SBP systolic blood pressure mmHg; DBP diastolic blood pressure mmHg; TC total cholesterol; TG triglycerides; HDL high density lipoproteins; LDL low density lipoproteins; ap0 apolipoproteins; IGR insulin:glucose ratio.…”

Section: Discussionmentioning

confidence: 97%

“…26 Apo (a) polymorphism is essentially genetically determined, and affects the total mass of the Lp(a) protein and its density. 26 An inverse correlation of the serum Lp(a) concentrations with the molecular weight of the apo(a) isoform and with the size of the corresponding apo(a) gene 17,26 has indeed been demonstrated in Caucasian subjects in whom it has also been estimated that between 41 and 90% of the serum concentration is determined by the apo(a) polymorphism. 25 ± 27 This correlation, and the latter quoted percentage, is inconsistent in all populations, being as low as 19% in Sudanese blacks, 26 and it has not been described, to our knowledge, in an Arab population.…”

Section: Discussionmentioning

confidence: 99%

“…32 ± 35 In many populations, a serum Lp(a) concentration b 300 mgal is considered indicative of increased atherogenic risk. 26,36,37 However, levels of Lp(a) are racially and genetically determined, and it is probably not appropriate to use the same Lp(a) cut-off point to assign CHD risk in all populations. We have therefore used the 75th percentile of values obtained in our study population to indicate hyper-Lp(a)-aemia and possibly increased risk.…”

Section: Lp(a) and Anthropometric Demographic And Biochemical Paramementioning

confidence: 99%

“…These observations are at some variance with reports elsewhere, where an inverse correlation between the number of kringle IV repeats and Lp(a) concentrations has been described. 20,26 It could be a racial variation. However, it is still possible to postulate from our data that subjects with the rapidly migrating, low molecular weight (LMW) phenotype F with a relatively smaller number of kringle IV repeats would have much higher serum Lp(a) concentrations and thus a greater CHD risk than those with the more slowly migrating, relatively high molecular weight (HMW) phenotype such as S4.…”

Section: Apo(a) Polymorphismmentioning

confidence: 99%

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Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

1999

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BACKGROUND: Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The basis for this atherogenic property of Lp(a) and the factors that in¯uence its cross-population levels, however, remain poorly understood. OBJECTIVES: To investigate the relationship between serum Lp(a) and metabolic and anthropometric parameters in a healthy Kuwaiti population. DESIGN: Cross-sectional study. SUBJECTS: 177 (72 male, 105 female) randomly recruited healthy Kuwait Arabs aged 17 ± 60 y MEASUREMENTS: Metabolic parameters in serum: Lp(a), apo(a) phenotypes, lipids and lipoproteins, glucose and urate. Anthropometric parameters: body mass index (BMI) and waist:hip-ratio (WHR). RESULTS: The distribution of Lp(a) concentrations was positively skewed (median 153 mgal, range 0 ± 1086). Women had higher concentrations ± (194, 0 ± 1086) than men (117, 0 ± 779), P 0.069. Lp(a) and insulin concentrations were signi®cantly higher when the men and women were obese. In all subjects, there were signi®cant correlations between Lp(a) and BMI (r 0.23), total cholesterol (TC) (r 0. Multivariate analyses con®rmed BMI and low-density lipoprotein (LDL) as the signi®cant determinants of serum Lp(a).On apo (a) phenotyping, 114 (67%), 51 (30%) and 6 (4%) had single, double and null phenotypes respectively. The isoforms and their corresponding kringle IV repeat numbers were: F (14 repeats in 3%, mean Lp(a) 497 mgal); S1 (19 repeats in 14%, mean 245 mgal); S2 (23 repeats in 16%, mean 264 mgal); S3 (27 repeats in 35%, mean 236 mgal); and S4 (35 repeats in 28%, mean 235 mgal). DISCUSSION AND CONCLUSION: The results from the Kuwaiti population studied suggest that: (1) serum Lp(a) concentrations and distribution are similar to the pattern in Caucasians and Asians but not African ± Americans or Africans; (2) serum Lp(a) is variably in¯uenced by BMI and LDL ± the impact of either factor differs between the sexes; (3) there is a high frequency of the single-banded phenotype; (4) contrary to reports in some Caucasian and Asian populations, there is no simple relationship between kringle IV repeat numbers and plasma Lp(a) concentrations.

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Section: Lp(a) and Anthropometric Demographic And Biochemical Paramesupporting

confidence: 52%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Lp(a) and Anthropometric Demographic And Biochemical Paramementioning

confidence: 99%

Section: Apo(a) Polymorphismmentioning

confidence: 99%

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Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

1999

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Study of hemolysis interference with a peak rate nephelometric assay of lipoprotein(a)

Lefèvre

Gillery

2000

Lab. Robotics Autom.

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Lipoprotein(a) [Lp(a)] is considered an independent risk factor in atherosclerosis and thrombosis. Its measurement in clinical laboratories necessitates the use of reliable methods and a strict control of preanalytical conditions. We studied here the potential interference of hemolysis on a peak rate nephelometric method. Serum samples were spiked with up to 500 lmol/L hemoglobin (Hb), and Lp (a) was measured with a Beckman Array 360 analyzer. Hb supplementation induced a significant decrease of Lp(a) values: ‫%51מ‬ and ‫%52מ‬ (p Ͻ 0.01) for Hb concentrations 200 and 500 lmol/L, respectively. Similar results were obtained when Hb addition was done before and after the manual step of sample predilution (1/5, v/v) in PEG-containing buffer. No significant difference of Hb interference was noticed according to apo(a) phenotypes. Our results indicate that hemolysis may significantly alter Lp(a) values obtained with this method, probably because of the low-dilution rate of samples. Even if this interference is of limited extent, it should be taken into account when interpretating results close to decisional values used for risk assessment.

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Study of hemolysis interference with a peak rate nephelometric assay of lipoprotein(a)

Lefèvre,

Gillery

2000

Lab. Robotics Autom.

View full text Add to dashboard Cite

Lipoprotein(a) [Lp(a)] is considered an independent risk factor in atherosclerosis and thrombosis. Its measurement in clinical laboratories necessitates the use of reliable methods and a strict control of preanalytical conditions. We studied here the potential interference of hemolysis on a peak rate nephelometric method. Serum samples were spiked with up to 500 lmol/L hemoglobin (Hb), and Lp(a) was measured with a Beckman Array 360 analyzer. Hb supplementation induced a significant decrease of Lp(a) values: ‫%51מ‬ and ‫%52מ‬ (p Ͻ 0.01) for Hb concentrations 200 and 500 lmol/L, respectively. Similar results were obtained when Hb addition was done before and after the manual step of sample predilution (1/5, v/v) in PEG-containing buffer. No significant difference of Hb interference was noticed according to apo(a) phenotypes. Our results indicate that hemolysis may significantly alter Lp(a) values obtained with this method, probably because of the low-dilution rate of samples. Even if this interference is of limited extent, it should be taken into account when interpretating results close to decisional values used for risk assessment.

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Lipoprotein [a]

Cited by 13 publications

References 342 publications

Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

Study of hemolysis interference with a peak rate nephelometric assay of lipoprotein(a)

Study of hemolysis interference with a peak rate nephelometric assay of lipoprotein(a)

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