Abstract:We examined the effect of LPS on thrombin-and histamine-stimulated rises in intracellular calcium concentration ([Ca 2+ ] i ) in cultured human umbilical vein endothelial cells (HUVEC). HUVEC were incubated with LPS for up to 24 h. After harvesting and labeling with Quin-2/AM, HUVEC were stimulated with thrombin or histamine, and rises in [Ca 2+ ] i were monitored. LPS (0.01-10 μg/ml) significantly suppressed the rise in [Ca 2+ ] i induced by 2 U/ml thrombin or 10 μM histamine. The degree of suppression … Show more
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