Lipopolysaccharide (LPS) induced sickness in early adolescence alters the behavioral effects of the short-chain fatty acid, propionic acid, in late adolescence and adulthood: Examining anxiety and startle reactivity

Wah, Deanne Tak On; Kavaliers, Martin; Bishnoi, Indra R.; Ossenkopp, Klaus‐Peter

doi:10.1016/j.bbr.2018.12.003

Cited by 18 publications

(7 citation statements)

References 43 publications

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“…Our study is the first to examine these tasks across developmental ages in the mouse, allowing for direct comparison between age groups. Our findings for PPI are in accord with the previous individual studies in showing that sensorimotor gating develops with age, whereby adult animals display greater PPI compared to adolescent animals [ 43 , 45 , 47 ]. Similarly, previous work assessing drug-induced locomotor activity in rats at postnatal day 32 [ 48 ] and mice at postnatal day 35 [ 46 ] compared to adult animals (postnatal day 70) has shown similar differences to that observed between 4.5 and 12 W mice in our work.…”

Section: Discussionsupporting

confidence: 92%

Cognitive behavioral markers of neurodevelopmental trajectories in rodents

et al. 2021

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Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that shape cognitive processing. Adolescence also represents a vulnerable period for the onset of symptoms in neurodevelopmental psychiatric disorders. Despite the wide use of rodent models to unravel neurobiological mechanisms underlying neurodevelopmental disorders, there is a surprising paucity of rigorous studies focusing on normal cognitive-developmental trajectories in such models. Here, we sought to behaviorally capture maturational changes in cognitive trajectories during adolescence and into adulthood in male and female mice using distinct behavioral paradigms. C57 BL/6J mice (4.5, 6, and 12 weeks of age) were assessed on three behavioral paradigms: drug-induced locomotor hyperactivity, prepulse inhibition, and a novel validated version of a visuospatial paired-associate learning touchscreen task. We show that the normal maturational trajectories of behavioral performance on these paradigms are dissociable. Responses in drug-induced locomotor hyperactivity and prepulse inhibition both displayed a ‘U-shaped’ developmental trajectory; lower during mid-adolescence relative to early adolescence and adulthood. In contrast, visuospatial learning and memory, memory retention, and response times indicative of motivational processing progressively improved with age. Our study offers a framework to investigate how insults at different developmental stages might perturb normal trajectories in cognitive development. We provide a brain maturational approach to understand resilience factors of brain plasticity in the face of adversity and to examine pharmacological and non-pharmacological interventions directed at ameliorating or rescuing perturbed trajectories in neurodevelopmental and neuropsychiatric disorders.

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Section: Discussionsupporting

confidence: 92%

Cognitive behavioral markers of neurodevelopmental trajectories in rodents

et al. 2021

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“…The vehicle (VEH) control groups received a matching dose of 0.9% NaCl. A dosage of 200 μg/kg LPS has been shown to elicit sickness behavior in adolescent Long-Evans rats (Wah et al, 2019). As PND 30 and 32 are widely regarded as early adolescence for Long-Evans rats (Lupien et al, 2009;Spear & Swartzwelder, 2014), they were selected as the early adolescent treatment days.…”

Section: Drugsmentioning

confidence: 99%

“…There have been limited investigations into the effects of adolescent LPS administration. Recent studies have found that exposure to LPS during early adolescence can have immediate and long-lasting behavioral effects, altering both late adolescent and adult behavior (Cloutier et al, 2018;Spear & Swartzwelder, 2014;Wah et al, 2019). Specifically, increases in anxiety-like behavior and decreases in locomotor activity in late adolescent and adult males were found after early adolescent LPS exposure (Wah et al, 2019).…”

Section: Lps Effectsmentioning

confidence: 99%

“…The majority of investigations into the effects of LPS in adolescence and adulthood has focused on exposure during the prenatal and neonatal critical periods of development (Batinić et al, 2016;Foley, Ossenkopp, Kavaliers, & MacFabe, 2014;Ji et al, 2016;Tenk, Kavaliers, & Ossenkopp, 2008. More recent studies have found that exposure to LPS during early adolescence can have immediate and long-lasting behavioral effects, altering both late adolescent and adult behavior (Cloutier, Kavaliers, & Ossenkopp, 2018;Spear & Swartzwelder, 2014;Wah, Kavaliers, Bishnoi, & Ossenkopp, 2019). For example, Wah et al (2019) found an increase in anxiety-like behavior and decrease in locomotor activity in late adolescent and adult male rats after early adolescent LPS exposure.…”

Section: Introductionmentioning

confidence: 99%

“…More recent studies have found that exposure to LPS during early adolescence can have immediate and long-lasting behavioral effects, altering both late adolescent and adult behavior (Cloutier, Kavaliers, & Ossenkopp, 2018;Spear & Swartzwelder, 2014;Wah, Kavaliers, Bishnoi, & Ossenkopp, 2019). For example, Wah et al (2019) found an increase in anxiety-like behavior and decrease in locomotor activity in late adolescent and adult male rats after early adolescent LPS exposure. As such, early adolescent LPS exposure may alter certain risk-taking behaviors, such as the increase in locomotor behavior and lowered anxiety levels (Spear, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Sex and age differences in locomotor and anxiety‐like behaviors in rats: From adolescence to adulthood

Bishnoi

Ossenkopp

Kavaliers

2020

Developmental Psychobiology

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Risk-taking behaviors are a primary contributor to elevated adolescent injury and mortality. Locomotor and anxiety-like behaviors in rodents have been used to examine risk-taking. Here, we examined risk-taking behavior (i.e., changes in locomotor and anxiety-like behaviors) from early to late adolescence and adulthood in male and female rats in the open-field (OF) apparatus and the light-dark (LD) test. We also examined whether these behaviors are affected by an early adolescent immune stressor, lipopolysaccharide (LPS). Long-Evans male and female rats were injected with LPS (200 μg/kg

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