Lipopolysaccharide-induced lung cell inflammation and apoptosis are enhanced by circ_0003420/miR-424-5p/TLR4 axis via inactivating the NF-κB signaling pathway

Yang, Hu; Zhang, Chunmei; Zhao, Zhongyan

doi:10.1016/j.trim.2022.101639

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…10 Further study revealed that polysaccharides of Dangshen could effectively inhibit the proliferation of gastric cancer AGS cells, induce apoptosis and inhibit the secretion of pro-inflammatory factors, the mechanism of which may be related to the regulation of the miR-361-5p/ TLR4/NF-κB pathway. 11 Based on the above study, we propose the hypothesis that DHJ may have a protective effect on the gastric mucosa.…”

Section: Introductionmentioning

confidence: 93%

Dangshen Huangjiu prevents gastric mucosal injury and inhibits Akt/NF-κB pathway

Xu,

Cui,

et al. 2023

Food Funct.

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Section: Introductionmentioning

confidence: 93%

Dangshen Huangjiu prevents gastric mucosal injury and inhibits Akt/NF-κB pathway

Xu,

Cui,

et al. 2023

Food Funct.

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“…In mechanism, miR-424-5p was predicted to bind with circRNA_0001006 and was reported to serve as a tumor suppressor in breast cancer. miR-424-5p was also involved in the function of many other circRNAs, such as the inhibition of gastric cancer cells by circ_LARP4, the promoter role of circ_RNF13 in HBV-hepatocellular carcinoma, and the enhancement of lung cell inflammation by cicr_0003420 [ 11 – 13 ]. Therefore, circRNA_0001006 might regulate the development of TNBC, and whether miR-424-5p mediates the function of circ_0001006 was also estimated.…”

Section: Introductionmentioning

confidence: 99%

circRNA_0001006 predicts prognosis and regulates cellular processes of triple-negative breast cancer via miR-424-5p

Liu

Kong

Bian³

et al. 2023

Cell Div

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Background circular RNAs (circRNAs) have been considered novel biomarker candidates for human cancers, such as triple-negative breast cancer (TNBC). circ_0001006 was identified as a differentially expressed circRNA in metastatic breast cancer, but its significance and function in TNBC were unclear. The significance of circ_0001006 in TNBC was assessed and exploring its potential molecular mechanism to provide a therapeutic target for TNBC. Results circ_0001006 showed significant upregulation in TNBC and close association with patients’ histological grade, Ki67 level, and TNM stage. Upregulated circ_0001006 could predict a worse prognosis and high risk of TNBC patients. In TNBC cells, silencing circ_0001006 suppressed cell proliferation, migration, and invasion. In mechanism, circ_0001006 could negatively regulate miR-424-5p, which mediated the inhibition of cellular processes by circ_0001006 knockdown. Conclusions Upregulated circ_0001006 in TNBC served as a poor prognosis predictor and tumor promoter via negatively regulating miR-424-5p.

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“…Shen et al (14) underscored that circ_0003091 was involved in lung injury, apoptosis, and inflammation in a SA-ALI mouse model by targeting miR-149/Smad2 pathway. Yang et al (15) demonstrated circ_0003420 deficiency alleviated LPS-mediated lung injury and inflammatory processes by targeting miR-424-5p and regulating TLR4 levels. Zhu et al (16) uncovered that circ_0001679 was elevated in LPS-stimulated MLE-12 cells, and interference of circ_0001679 restrained LPS-induced apoptosis and production of pro-inflammatory cytokines by targeting the miR-338-3p/DUSP16 network.…”

Section: Introductionmentioning

confidence: 99%

Interfering Hsa_circ_0001226 Mitigates LPS-Induced Beas-2b Cell Injury by Regulating Mir-940/Tgfbr2 Pathway

Mo,

Yi,

Bei

et al. 2023

Shock

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Background: Sepsis-associated acute lung injury (SA-ALI) is a serious threat to human health. A growing body of evidence suggested that circular RNAs may be involved in ALI progression. The aim of this study was to investigate the effect and mechanism of circ_0001226 on lipopolysaccharide (LPS)–induced BEAS-2B cells. Methods: BEAS-2B cells were stimulated with LPS to establish a SA-ALI cell model. The expression of circ_0001226, miR-940, and transforming growth factor beta receptor II (TGFBR2) were monitored by quantitative real-time polymerase chain reaction. Cell proliferation and apoptosis were evaluated by the Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine assay, and flow cytometry. The levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α were calculated by enzyme-linked immunosorbent assay. Western blot was implemented to test the protein levels of PCNA, Bax, and TGFBR2. Dual-luciferase reporter assay and RNA pull-down assay were adopted to investigate the interaction between circ_0001226 and miR-940, as well as TGFBR2 and miR-940. Results: The levels of circ_0001226 and TGFBR2 were elevated, and miR-940 was decreased in SA-ALI serum specimens and LPS-evoked BEAS-2B cells. Besides that, circ_0001226 interference contributed to cell proliferation and restrained apoptosis and inflammation in LPS-induced BEAS-2B cells. Mechanically, circ_0001226 worked as a molecular sponge of miR-940 to regulate TGFBR2 expression. Conclusion: Circ_0001226 deficiency weakened LPS-mediated proliferation inhibition and inflammatory processes in BEAS-2B cells by binding miR-940 and regulating TGFBR2.

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Lipopolysaccharide-induced lung cell inflammation and apoptosis are enhanced by circ_0003420/miR-424-5p/TLR4 axis via inactivating the NF-κB signaling pathway

Cited by 4 publications

References 28 publications

Dangshen Huangjiu prevents gastric mucosal injury and inhibits Akt/NF-κB pathway

Dangshen Huangjiu prevents gastric mucosal injury and inhibits Akt/NF-κB pathway

circRNA_0001006 predicts prognosis and regulates cellular processes of triple-negative breast cancer via miR-424-5p

Interfering Hsa_circ_0001226 Mitigates LPS-Induced Beas-2b Cell Injury by Regulating Mir-940/Tgfbr2 Pathway

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