Lipopolysaccharide-induced immune activation impairs attention but has little effect on short-term working memory

Holden, John Michael; Meyers-Manor, Julia E.; Overmier, J. Bruce; Gahtan, Ethan; Sweeney, Whitney A.; Miller, Holly C.

doi:10.1016/j.bbr.2008.06.032

Cited by 28 publications

(12 citation statements)

References 43 publications

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“…Some have demonstrated changes in memory function in response to inflammation (Krabbe et al, 2005), whereas others have not (Grigoleit et al, 2010;Holden et al, 2008). There appears to be more consistent evidence towards no effect of inflammation on cognitive function, but these studies utilized alternative methods to increase inflammatory markers, such as lipopolysaccharide administration, which in addition to enhancing inflammatory levels can also induce other effects including fever, sickness, and malaise (Grigoleit et al, 2010;Holden et al, 2008;Krabbe et al, 2005). However, others have revealed that IL-6 increases can lead to slower reaction time (Brydon, Harrison, Walker, Steptoe, & Critchley, 2008), which might be a reason for a decline in the number of correct answers during the second completion of the PASAT in these studies.…”

Section: Discussionmentioning

confidence: 99%

Induced mild systemic inflammation is associated with impaired ability to improve cognitive task performance by practice

et al. 2014

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Elevated inflammatory levels are linked to poorer cognition, but experimental confirmation is lacking. This report examined associations between cognitive performance and inflammation induced by exercise and vaccination. Thirty-six (exercise N = 18, vaccination N = 18) healthy males completed a paced auditory serial addition test (PASAT), which is a multifaceted measure of cognitive function. The task was completed in placebo and elevated inflammation states. Improvements in PASAT performance were related to inflammation. In the exercise study, IL-6 during the first PASAT negatively correlated with PASAT improvement (p = .022). In the vaccination study, increases in C-reactive protein between PASATs correlated with reduced PASAT improvement (p < .001). Inflammation was linked to reduced improvements in cognitive performance. Further research should identify the specific cognitive functions affects and the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Induced mild systemic inflammation is associated with impaired ability to improve cognitive task performance by practice

et al. 2014

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“…Immune gene upregulation, especially within the CNS, has been demonstrated to impair a variety of cognitive domains, including learning (Barrientos and others 2009; Barrientos and others 2006; Hein and others ; Terrando and others 2010), memory (Abraham and Johnson 2009; Frank and others ; Hirshler and others 2010; Wang and others 2009), and attention (Holden and others 2008). Administration of non-steroidal anti-inflammatory agents (e.g., celecoxib) has improved cognitive function in aging rodents (Trompet and others 2008) .…”

Section: Discussionmentioning

confidence: 99%

Parallel declines in cognition, motivation, and locomotion in aging mice: Association with immune gene upregulation in the medial prefrontal cortex

Bordner

Kitchen

Carlyle

et al. 2011

Experimental Gerontology

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Aging in humans is associated with parallel changes in cognition, motivation, and motoric performance. Based on the human aging literature, we hypothesized that this constellation of age-related changes is mediated by the medial prefrontal cortex and that it would be observed in aging mice. Toward this end, we performed detailed assessments of cognition, motivation, and motoric behavior in aging mice. We assessed behavioral and cognitive performance in C57Bl/6 mice aged 6, 18, and 24 months, and followed this with microarray analysis of tissue from the medial prefrontal cortex and analysis of serum cytokine levels. Multivariate modeling of these data suggested that the age-related changes in cognition, motivation, motor performance, and prefrontal immune gene expression were highly correlated. Peripheral cytokine levels were also correlated with these variables, but less strongly than measures of prefrontal immune gene upregulation. To determine whether the observed immune gene expression changes were due to prefrontal microglial cells, we isolated CD11b-positive cells from the prefrontal cortex and subject them to next-generation RNA sequencing. Many of the immune changes present in whole medial prefrontal cortex were enriched in this cell population. These data suggest that, as in humans, cognition, motivation, and motoric performance in the mouse change together with age and are strongly associated with CNS immune gene upregulation.

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“…Several studies on other species also show that immune activation does not impair short-term working memory. It has been reported that LPS-induced immune activation can impair attention but not short-term working memory in pigeons [107] . In human, 0.8 ng/kg LPS can induce an improvement in working memory, but an impairment in declarative memory [108] .…”

Section: Specific Types and Stages Of Memory Memory Appearsmentioning

confidence: 95%

Interleukin-1β with learning and memory

Huang

Sheng²

2010

Neurosci. Bull.

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Abstract:Interleukin-1 (IL-1) is one of the first cytokines ever described. It has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness.Recently, accumulating evidence has indicated that IL-1 also adversely affects cognitive function. Nevertheless, there are also some reports showing no effects or even beneficial effects of IL-1 on learning and memory. The relationship between IL-1 and cognitive impairment has not been clearly elucidated. Here we reviewed the evidence of both negative and positive effects of IL-1 on learning and memory, and the key factors that may affect the effects of IL-1 on learning and memory were discussed.

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Lipopolysaccharide-induced immune activation impairs attention but has little effect on short-term working memory

Cited by 28 publications

References 43 publications

Induced mild systemic inflammation is associated with impaired ability to improve cognitive task performance by practice

Induced mild systemic inflammation is associated with impaired ability to improve cognitive task performance by practice

Parallel declines in cognition, motivation, and locomotion in aging mice: Association with immune gene upregulation in the medial prefrontal cortex

Interleukin-1β with learning and memory

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