Lipopolysaccharide impairs mucin secretion and stimulated mucosal immune stress response in respiratory tract of neonatal chicks

Fan, Xiaohui; Jiao, Hongchao; Zhao, Jingpeng; Wang, Xiao-Juan

doi:10.1016/j.cbpc.2017.11.011

Cited by 2 publications

(2 citation statements)

References 68 publications

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“…Studies conducted in in vivo and in vitro models have provided evidence that polyphenol as well as polyphenol-rich foods have beneficial effects on gut health, such as modulation of mucosal immune and inflammatory response via downregulation of inflammatory cytokines and suppression of pro-inflammatory signaling pathways (129–131). Lipopolysaccharide (LPS), an endotoxin released by gram-negative bacteria, is important for the induction of gut mucosal permeability by provoking inflammatory responses and aggravating inflammation-related chronic conditions such as obesity and insulin resistance (132, 133). It has been proved that polyphenols might ameliorate the development of metabolic endotoxemia by interfering with LPS in the gut lumen (134).…”

Section: Energy Metabolism Regulatory Mechanisms Involving Dietary Pomentioning

confidence: 99%

Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites

Lin

Wang

Lam

et al. 2019

Food & Nutrition Research

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Background Polyphenols are a class of plant secondary metabolites with a variety of physiological functions. Polyphenols and their intestinal metabolites could greatly affect host energy metabolism via multiple mechanisms. Objective The objective of this review was to elaborate the role of intestinal microecology in the regulatory effects of dietary polyphenols and their metabolites on energy metabolism. Methods In this review, we illustrated the potential mechanisms of energy metabolism regulated by the crosstalk between polyphenols and intestinal microecology including intestinal microbiota, intestinal epithelial cells, and mucosal immune system. Results Polyphenols can selectively regulate the growth of susceptible microorganisms (eg. reducing the ratio of Firmicutes to Bacteroides, promoting the growth of beneficial bacteria and inhibiting pathogenic bacteria) as well as alter bacterial enzyme activity. Moreover, polyphenols can influence the absorption and secretion of intestinal epithelial cells, and alter the intestinal mucosal immune system. Conclusion The intestinal microecology play a crucial role for the regulation of energy metabolism by dietary polyphenols.

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Section: Energy Metabolism Regulatory Mechanisms Involving Dietary Pomentioning

confidence: 99%

Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites

Lin

Wang

Lam

et al. 2019

Food & Nutrition Research

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“…Intensive farming seems to have become the norm for guaranteeing the efficient production of livestock and poultry. However, while intensive farming results in large-scale economies, it is subject to some serious problems, such as high feeding density, the need for frequent vaccination, improper management, a stressful environment, and a rapid increase in pathogenic infections, all of which lead to immune stress in livestock and poultry, through the loss of homeostasis [ 1 , 2 , 3 ]. Immune stress not only reduces the growth performance and antioxidant capacity of broilers, but also generates ROS through the production of excessive pro-inflammatory cytokines, resulting in oxidative damage [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aspirin Eugenol Ester on Liver Oxidative Damage and Energy Metabolism in Immune-Stressed Broilers

Zhong,

Zhen,

Bai

et al. 2024

Antioxidants

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The aim of this study was to investigate the effects of aspirin eugenol ester (AEE) on liver oxidative damage and energy metabolism in immune-stressed broilers. In total, 312 broilers were divided into 4 groups (saline, LPS, SAEE, and LAEE). Broilers in the saline and LPS groups were fed a basal diet; the SAEE and LAEE groups had an added 0.01% AEE in their diet. Broilers in the LPS and LAEE groups were injected with lipopolysaccharides, while the saline and SAEE groups were injected with saline. Results showed that AEE increased the body weight, average daily gain, and average daily feed intake, as well as decreasing the feed conversion ratio of immune-stressed broilers. AEE protects against oxidative damage in immune-stressed broiler livers by elevating the total antioxidant capacity, superoxide dismutase activity, and glutathione S-transferase alpha 3 (GSTA3) and glutaredoxin 2 (GLRX2) expression, while decreasing malondialdehyde content. AEE lessened inflammation by reducing prostaglandin-F2α production and prostaglandin-endoperoxide synthase 2 (PTGS2) and interleukin-1beta (IL-1β) expression. AEE decreased oxidative phosphorylation rates by increasing succinic acid levels and lowering both adenosine diphosphate (ADP) levels and ceroid lipofuscinosis neuronal 5 (CLN5) expression. AEE modulated the metabolism of phenylalanine, tyrosine, lipids, and cholesterol by reducing the phenyllactate and L-arogenate levels, lowering dopachrome tautomerase (DCT) and apolipoprotein A4 (APOA4) expression, and increasing phenylpyruvic acid and dopa decarboxylase (DDC) expression. In summary, AEE can effectively alleviate liver oxidative damage and energy metabolism disorders in immune-stressed broilers.

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Lipopolysaccharide impairs mucin secretion and stimulated mucosal immune stress response in respiratory tract of neonatal chicks

Cited by 2 publications

References 68 publications

Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites

Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites

Effects of Aspirin Eugenol Ester on Liver Oxidative Damage and Energy Metabolism in Immune-Stressed Broilers

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